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NCT ID: NCT03018028 Completed - Clinical trials for Diabetes Mellitus, Type 2

Dose-response, Safety and Efficacy of Oral Semaglutide Versus Placebo and Versus Liraglutide, All as Monotherapy in Japanese Subjects With Type 2 Diabetes

PIONEER 9
Start date: January 10, 2017
Phase: Phase 3
Study type: Interventional

This trial is conducted in Asia. The aim of this trial is to investigate the dose-response relationship of once-daily dosing of three dose levels (3, 7 and 14 mg) of oral semaglutide versus placebo as monotherapy on glycaemic control in Japanese subjects with type 2 diabetes mellitus

NCT ID: NCT03016325 Completed - Heart Failure Clinical Trials

Evaluate the Safety and Efficacy of 48-Hour Infusions of HNO (Nitroxyl) Donor in Hospitalized Patients With Heart Failure

STANDUP AHF
Start date: January 13, 2017
Phase: Phase 2
Study type: Interventional

A Study to Evaluate Safety and Efficacy of Continuous 48-Hour Intravenous Infusions of HNO Donor in Hospitalized Patients with Heart Failure and Impaired Systolic Function

NCT ID: NCT03016312 Completed - Clinical trials for Prostatic Neoplasms, Castration-Resistant

A Study of Atezolizumab (Anti-PD-L1 Antibody) in Combination With Enzalutamide in Participants With Metastatic Castration-Resistant Prostrate Cancer (mCRPC) After Failure of an Androgen Synthesis Inhibitor And Failure of, Ineligibility For, or Refusal of a Taxane Regimen

IMbassador250
Start date: January 10, 2017
Phase: Phase 3
Study type: Interventional

This Phase III, multicenter, randomized, open-label study will evaluate the safety and efficacy of atezolizumab (anti-programmed death-ligand 1 [anti-PD-L1] antibody) in combination with enzalutamide compared with enzalutamide alone in participants with mCRPC after failure of an androgen synthesis inhibitor (e.g., abiraterone) and failure of, ineligibility for, or refusal of a taxane regimen. Participants will be randomized to one of the two treatment arms (atezolizumab in combination with enzalutamide, and enzalutamide alone) in a 1:1 ratio (experimental to control arm) in global randomized phase. Participants will receive treatment until investigator-assessed confirmed radiographic disease progression per Prostate Cancer Working Group 3 (PCWG3) criteria or unacceptable toxicity.

NCT ID: NCT03015220 Completed - Clinical trials for Diabetes Mellitus, Type 2

Safety and Efficacy of Oral Semaglutide Versus Dulaglutide Both in Combination With One OAD (Oral Antidiabetic Drug) in Japanese Subjects With Type 2 Diabetes

PIONEER 10
Start date: January 10, 2017
Phase: Phase 3
Study type: Interventional

This trial is conducted in Asia. The aim of this trial is to investigate Safety and efficacy of oral semaglutide versus dulaglutide both in combination with one OAD (oral antidiabetic drug) in Japanese subjects with type 2 diabetes.

NCT ID: NCT03014895 Completed - Clinical trials for Healthy Male Volunteers

A Single Intravenous Dose Study of E3112 in Japanese Healthy Adult Male Subjects

Start date: January 25, 2017
Phase: Early Phase 1
Study type: Interventional

The study (E3112/CP1) is a single-center, randomized, double-blind, placebo-controlled, single intravenous ascending dose study conducted in Japanese healthy adult males to evaluate the pharmacokinetics (PK), safety, and immunogenicity of E3112 following a single intravenous dose of E3112.

NCT ID: NCT03014479 Completed - Type 2 Diabetes Clinical Trials

Study of the QOL Evaluation of Trelagliptin in Patients With Type 2 Diabetes Mellitus

TRENDS
Start date: February 18, 2017
Phase: Phase 4
Study type: Interventional

The purpose of this study is to assess the reduction in treatment burden during 12 weeks of trelagliptin administration in patients with type 2 diabetes on diet and exercise therapy only.

NCT ID: NCT03014206 Completed - Clinical trials for Adult Not Younger Than 65 Years

Prevenar13 Drug Use Investigation - Adults Aged 65 Years or Older-

Start date: June 15, 2015
Phase:
Study type: Observational [Patient Registry]

This study aims to understand the following items in post-marketing actual clinical settings to evaluate the safety of 13vPnC administered as a single dose in the elderly (adults aged 65 years or older). 1. To confirm the use in actual clinical settings 2. To confirm the occurrence of adverse events

NCT ID: NCT03013439 Completed - Anemia Clinical Trials

Dose-escalation Trial of the Safety, Pharmacokinetics, and Pharmacodynamics of Iron Isomaltoside (Monofer®)

Start date: January 6, 2017
Phase: Phase 1
Study type: Interventional

The trial is an open-label, 4 cohorts, sequential, dose-escalating, single dose trial.

NCT ID: NCT03012841 Completed - Atrial Fibrillation Clinical Trials

STOP Persistent AF

Start date: March 2, 2017
Phase: N/A
Study type: Interventional

To demonstrate safety and effectiveness of the Arctic Front Advanceā„¢ and Freezor MAX® Cardiac CryoAblation Catheters for the treatment of drug refractory recurrent symptomatic persistent atrial fibrillation (AF).

NCT ID: NCT03011372 Active, not recruiting - Clinical trials for MPN (Myeloproliferative Neoplasms)

A Study to Evaluate the Efficacy and Safety of Pemigatinib (INCB054828) in Subjects With Myeloid/Lymphoid Neoplasms With FGFR1 Rearrangement - (FIGHT-203)

Start date: April 25, 2017
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the efficacy and safety of pemigatinib (INCB054828) in subjects with myeloid/lymphoid neoplasms with fibroblast growth factor receptor (FGFR) 1 rearrangement.