There are about 4957 clinical studies being (or have been) conducted in Japan. The country of the clinical trial is determined by the location of where the clinical research is being studied. Most studies are often held in multiple locations & countries.
Observational study of abatacept in the treatment of JIA in Japan.
To test efficacy and safety of a novel nasal spray of oxytocin on social deifies in autism spectrum disorder, and To compare effect sizes of different doses
The purpose of this study is to evaluate the safety of reducing dual antiplatelet therapy (DAPT) duration to 1 month after implantation of the everolimus-eluting cobalt-chromium stent (CoCr-EES) under the setting of acute coronary syndrome (ACS).
As surgery enters the era of value-based care, it is advocated that postoperative recovery be measured using patient-reported outcomes (PROs) as they provide a mean to incorporate the patient's perspectives and experiences into research and clinical decision-making. In abdominal surgery, this is currently precluded by the lack of PRO measures specifically developed and validated in the context of postoperative recovery. The core goal of this research project is to develop a PRO measure aimed to assess postoperative recovery from the perspective of patients undergoing abdominal surgery. This project complies with the US Food and Drug Administration (FDA) and International Society for Pharmacoeconomics and Outcomes Research (ISPOR) guidelines for PRO development and will be conducted in three phases: Phase 1: Qualitative interviews with patients to develop a conceptual framework and generate relevant items. Phase 2: Use of Rasch Analysis for item-reduction and scale formation. Phase 3: Further assessment of measurement properties based on traditional psychometric methods.
For hemodialysis subjects not receiving ESAs with anemia associated with chronic kidney disease, evaluate Hb correction and maintenance effect and safety of MT-6548.
To investigate effects on combination use of Ramelteon in the dose reduction or interruption process of (non-)BZD hypnotics during the dose reduction or interruption algorithm.
The purposes of this study are to evaluate bioequivalence between a single-dose of TAK-438ASA tablet versus a single-dose combination of TAK-438 tablet 10 mg and aspirin enteric-coated tablet 100 mg in Japanese healthy adult men (Study 1), and to evaluate the effects of food on the pharmacokinetics of TAK-438ASA tablet in Japanese healthy adult men (Study 2).
This is a multicenter, open-label, Phase 2 study to assess the efficacy and safety of tazemetostat in participants with relapsed or refractory B-cell non-Hodgkin's lymphoma (NHL) with EZH2 gene mutation.
This is a prospective, observational, single-center, single-arm, clinical trial designed to assess the efficacy of FFRangio in measuring FFR obtained from angiography compared to Invasive FFR for diagnosing hemodynamically significant coronary stenosis in Multi-Vessel Disease.
Diabetic Peripheral Neuropathy (DPN) is the common complication seen in the diabetic patients. Moreover, it will lead to another complication as disabilities and difficulties in activities of daily living (ADL). Most of the intervention for diabetes and diabetic neuropathic patients are mostly focusing on the prevention of foot ulcer. Diabetic foot care can prevent only for diabetes-related foot ulcer and foot amputation. It cannot be reduced DPN and cannot be improved the activities of daily living of the patient with DPN. Moreover, there is the restriction of weight-bearing exercise on the recommendation of exercises for the patients with DPN. Therefore, exercise program which may be suitable for all the patients with DPN was introduced in this study to improve ADL and decrease the neuropathic symptoms in the diabetic patients. Compliance with exercise or intervention is not only critical to get adherence but also for the long-term use of its. Easy to do exercise in the short duration which can able to do on their own in their home promote their compliance and adherence to the exercises. In this study, the effectiveness of exercises in the patients with diabetic peripheral neuropathy was examined to fulfill the requirement of exercises which is simple and can be done in a short time. The objective of the study is to examine the effectiveness of exercise in the patients with diabetic peripheral neuropathy. Randomise controlled trial was used in this study. Data collection was done at the outpatient diabetic clinic in North-Okkalapa General Hospital (NOGH), and University of Nursing, Yangon. The inclusion criteria for the participants were the patients receiving diabetic care at the out-patient-department of designated hospitals, able to contact via the telephone, presence of signs and symptoms of DPN, agreed to involve in the study (informed consent), and aged over 25 years. The persons who are suffering from DPN other than diabetes, severe illness of diabetic patients, diabetes with other comorbidities, amputation of hands and feet from any reasons, mental illness and alcoholism will be excluded from this study. By using a randomizing table, the patients who met the including criteria and had already examined the presence of DPN in the prevalence study of DPN were assigned intervention (n=61) and control group (n=60) and invited to participate in the second study. After getting informed consent, further assessment and examination were done on the day of data collection because some parts of data collection have already done in the prevalence study. Research assistants have trained all procedures including interviewing with the questionnaires and physical assessments. The instruments used in this study are Patient Neurotoxicity Questionnaire (PNQ), short-form McGill Pain Questionnaire (SF-MPQ), Behavioural Rating Scale and visual analog scale (0-100) as the standardized instruments in this study. Physical assessments were done for hand grip, pinch force, 10-g Semmes-Weinstein Monofilament (SWM) test, Timed Up and Go (TUG) test. A1cGEARs was used to check HbA1C level of the diabetic neuropathic patients. Finger counting time also recorded by using the stopwatch. The participants in the intervention group learned the exercise program by demonstration, using audio-visual aids. Hand and finger exercises and foot exercises were used as the intervention in this study. The intervention was developed by modifying some exercise for arthritis and other neuropathy. The permission to use some parts of their exercise has already got from the responsible person of the sources. The exercises lasted 10 minutes for all of the exercises completely. Health education about foot care was provided to the control group and the intervention group. The data collection points were before the intervention, immediately after the intervention (eight weeks), and follow-up eight weeks after the intervention. This study had already obtained ethical clearance from Nursing Science Ethical Review Committee, Graduate School of Health Sciences, Okayama University, Japan with the review number of D16-07, University of Nursing, Yangon, and Department of Medical Research (Lower Myanmar) with approval number Ethics/DMR/2017/048.