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NCT ID: NCT03671564 Recruiting - Clinical trials for Acute Myeloid Leukemia

Phase 1 Study of Milademetan in Japanese Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML)

Start date: August 23, 2018
Phase: Phase 1
Study type: Interventional

This is a Phase 1, multicenter, open-label study to evaluate safety, tolerability and pharmacokinetics of milademetan in Japanese patients with relapsed or refractory acute myeloid leukemia. The milademetan initial dose will be Level 1: 90 mg. No increase in the milademetan dose will be made in the same participant. Dose-limiting toxicity associated with milademetan occurring at each level will be assessed, and the maximum tolerated dose (MTD) will be decided using a modified continuous reassessment method (mCRM).

NCT ID: NCT03663582 Recruiting - Clinical trials for Short Bowel Syndrome

Study of Teduglutide in Japanese Participants With Short Bowel Syndrome

Start date: November 1, 2018
Phase: Phase 3
Study type: Interventional

The objectives of this clinical study are to evaluate the safety, efficacy, and pharmacokinetics (PK) of teduglutide in Japanese participants with short bowel syndrome (SBS) who are dependent on parenteral nutrition/intravenous (PN/IV) over a 24-week treatment period.

NCT ID: NCT03663114 Recruiting - Clinical trials for Carcinoma, Hepatocellular

A Post-marketing Observational Study on Risk Factors for Hepatic Encephalopathy in Participants With Unresectable Hepatocellular Carcinoma

Start date: July 2, 2018
Phase:
Study type: Observational

This study is a post-marketing observational study of lenvatinib in participants with unresectable hepatocellular carcinoma. The primary objective of this study is assessment of risk factors for hepatic encephalopathy.

NCT ID: NCT03661138 Not yet recruiting - Atopic Dermatitis Clinical Trials

A Study to Evaluate Safety of Upadacitinib in Combination With Topical Corticosteroids in Adolescent and Adult Participants With Moderate to Severe Atopic Dermatitis

Start date: September 26, 2018
Phase: Phase 3
Study type: Interventional

The objective of this study is to assess the safety of upadacitinib combined with topical corticosteroids (TCS) in adolescent and adult participants in Japan with moderate to severe atopic dermatitis (AD) who are candidates for systemic therapy.

NCT ID: NCT03658096 Enrolling by invitation - Clinical trials for Triangular Fibrocartilage Complex Injury

Quantitative Assessment of Distal Radioulnar Joint Stability With Pressure-Monitor Ultrasonography

Start date: September 1, 2017
Phase: N/A
Study type: Interventional

To quantitatively assess distal radio ulnar joint (DRUJ) stability, a pressure-monitor ultrasound system was developed. The objective of this study was to evaluate the force-displacement relationship of DRUJ in patients and normal subjects. Each subject will be imaged sitting with elbow flexed and forearm pronated. The dorsal surface of distal radius and the center of ulnar head will be displayed at DRUJ level. The pressure toward palmar direction will be applied to distal ulna with different levels of transducer displacements, i.e. 1 mm, 2 mm, and 3 mm. The distance between the dorsal surface of the ulnar head and the dorsal surface of the distal radius will be measured. At the same time, the pressure to the transducer will be measured.

NCT ID: NCT03657758 Not yet recruiting - Clinical trials for Coronary Artery Disease

Lesional Evaluation of High Risk Patients With Neoatherosclerosis Treated With Rosuvastatin and Eicosapentaenoic Acid Using OCT(LINK IT TWO)

Start date: September 1, 2018
Phase: Phase 4
Study type: Interventional

This study aim is to evaluate the additional effect of eicosapentaenoic acid and dose up effect of rosuvastatin for neoatherosclerosis in coronary artery disease patients.

NCT ID: NCT03654729 Not yet recruiting - Clinical trials for Chemotherapy-induced Peripheral Neuropathy

Preventive Treatment of Oxaliplatin Induced Peripheral Neuropathy in Metastatic Colorectal Cancer (POLAR-M)

POLAR-M
Start date: October 2018
Phase: Phase 3
Study type: Interventional

This study evaluates the investigational drug PledOx in the prevention of chronic chemotherapy induced peripheral neuropathy (CIPN) induced by the drug oxaliplatin.

NCT ID: NCT03645863 Recruiting - Healthy Clinical Trials

Effects of Iron Supplements on the Pharmacokinetics of MT-6548

Start date: August 27, 2018
Phase: Phase 3
Study type: Interventional

The objectives of this study are to investigate the pharmacokinetics and safety of MT-6548 co-administered with iron supplements in healthy male volunteers.

NCT ID: NCT03645421 Recruiting - Type 2 Diabetes Clinical Trials

Safety and Tolerability Study of MEDI0382 in Japanese Preobese or Obese Subjects With Type 2 Diabetes

Start date: August 10, 2018
Phase: Phase 2
Study type: Interventional

This is a Phase 2a study designed to assess the safety and tolerability of MEDI0382 titrated up to a dose level of 100, 200 or 300 µg from 50 µg vs Placebo across 48 days in Japanese subjects. The study D5674C00001 can be conducted with a reasonable expectation of safety and tolerability in Japanese T2DM patients. The design of this study has taken into account the known benefits and risks of GLP-1 receptor agonists and glucagon receptor agonists as well as the translatable effects observed in nonclinical studies of MEDI0382.

NCT ID: NCT03645330 Recruiting - Clinical trials for Non-small-Cell Lung Cancer

A Study of Atezolizumab in Patients With Unresectable, Locally Advanced or Metastatic Non-small Cell Lung Cancer

Start date: August 15, 2018
Phase:
Study type: Observational

This prospective, observational study is to assess the long-term effectiveness and safety of Atezolizumab in patients with advanced non-small cell lung cancer in clinical practice.