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NCT ID: NCT06031792 Recruiting - Clinical trials for Periapical; Infection

Radiographic Assessment of the Healing Pattern Associated Withperiradicular Endodontic Microsurgery

Start date: September 30, 2021
Phase: N/A
Study type: Interventional

Endodontic periradicular microsurgery is a dental procedure to treat apical periodontitis in cases in which healing has not occurred after non-surgical treatment or if it is not feasible. Recent advances in techniques and materials have resulted in more predictable outcomes. Piezotome is a new and innovative device, but limited evidence is available regarding its use in endodontics. The aim of this study is to assess the healing pattern of conventional periradicular microsurgery and piezoelectric periradicular microsurgery in 2- Dimensional and 3-Dimensional imaging, and further to perform histological analysis for the presence, location, and arrangement of bacteria in the excised apical portion of the root canal system.

NCT ID: NCT05992116 Recruiting - Clinical trials for Heart Failure With Reduced Ejection Fraction

Iron Deficiency in Patients With Heart Failure and Reduced and Mildly Reduced Ejection Fraction

Start date: September 1, 2023
Phase:
Study type: Observational

A significant percentage of patients with heart failure and reduced ejection fraction (HFrEF) or mildly reduced ejection fraction (HFmrEF) have iron deficiency who are symptomatic. This is independently associated with bad quality of life, low functional capacity, lower quality of, life and increased mortality. The prevalence of iron deficiency in HFrEF and HFmrEF patients in Jordan has not been studied in the past.

NCT ID: NCT05980936 Recruiting - Clinical trials for Obstructive Sleep Apnea

Screening for Obstructive Sleep Apnea in Medical Patients

Start date: October 15, 2023
Phase:
Study type: Observational

Obstructive sleep apnea (OSA) is highly prevalent in the general population and is associated with multiple adverse cardiovascular consequences. Screening for OSA is recommended in those with typical symptoms, such as daytime sleepiness, loud snoring, or abrupt awakenings with gasping or choking. Patients admitted to the general medical wards with these symptoms will be evaluated for the possibility of having OSA.

NCT ID: NCT05980923 Recruiting - Thyroid Dysfunction Clinical Trials

Thyroid Profiles in Patients With Acute Illness

Start date: October 15, 2023
Phase:
Study type: Observational

Patients admitted to the hospital with acute illness may have a wide spectrum of thyroid function abnormalities. It is largely unknown whether such aberrations are temporary or persist for a long time, and whether they impact prognosis of such patients.

NCT ID: NCT05949073 Recruiting - Gingival Recession Clinical Trials

The Impact of Retraction Cords on the Gingival Margin Level.

Start date: July 25, 2023
Phase: N/A
Study type: Interventional

The purpose of this study is to examine the relationship between placing specific retraction cord for different periods of time and the post-operative gingival margin level in humans. Determining the amount of immediate reversible and delayed irreversible gingival recession (vertical gingival retraction) that might happen after placing a retraction cord around a natural tooth in healthy humans. It also aims to investigate the impact of mechanical and chemo-mechanical gingival retraction on periodontal health.

NCT ID: NCT05898035 Recruiting - Pain Postoperative Clinical Trials

Postoperative Symptoms Following Endodontic Microsurgery

Start date: February 1, 2022
Phase: N/A
Study type: Interventional

Aims: The purpose of this randomized clinical trial is to assess and compare the post operative pain, swelling and quality of life after endodontic microsurgery using either conventional osteotomy or piezoelectric osteotomy . The PICO question that will be used is Does endodontic microsurgery using piezoelectric osteotomy have similar clinical performance in terms of post operative pain and swelling to that of endodontic microsurgery using conventional hand-piece osteotomy. Material and methods: based on solid inclusion criteria , a total of 44 patients in need of endodontic microsurgery will be randomly distributed into two groups (n=22) according to the osteotomy technique: conventional and piezoelectric osteotomy. A standardized microsurgical technique will be employed. After the microsurgery procedure, a pain questionnaire that contain visual analogue scale will be given to each patient to evaluate the pain incidence and intensity at 5 time intervals, 24 hours, 48 hours, 72 hours, 96 hours and 120 hours. The patients will be recalled as well, at days 2 and 7 to evaluate the swelling. Statistical analysis will be performed using chi-square test and linear regression analysis.

NCT ID: NCT05853835 Recruiting - Multiple Sclerosis Clinical Trials

First-in-Human Trial in Healthy Adult Volunteers to Evaluate Safety, Tolerability and PK of LAPIX Study Drug; LPX-TI641

Start date: October 30, 2023
Phase: Phase 1
Study type: Interventional

A Phase I First-in-Human, Randomized, Double-Blind, Placebo-Controlled Study in Healthy Adult Volunteers to Evaluate Safety, Tolerability, and Pharmacokinetics after Single Oral Dose of LPX-TI641.

NCT ID: NCT05822349 Recruiting - Type 2 Diabetes Clinical Trials

Effect of Using Pictograms on Improving Depression and Anxiety Among Type 2 Diabetic Patients.

Start date: April 1, 2023
Phase: N/A
Study type: Interventional

we will study the impact of using pictograms on improving depression and anxiety among type 2 diabetic patients, we suppose that patients who received pictograms-enriched labels will have lower levels of depression and anxiety in comparison with those who will not receive after three month follow-up evaluation.

NCT ID: NCT05774639 Recruiting - Clinical trials for Chronic Idiopathic Urticaria

Study to Compare Efficacy Safety and Immunogenicity of ADL-018 With XOLAIR (Omalizumab) in Adults With Chronic Idiopathic Urticaria

Start date: August 15, 2023
Phase: Phase 3
Study type: Interventional

The purpose of the study is to compare the efficacy, safety, tolerability, and immunogenicity of ADL-018 compared to XOLAIR in patients with Urticaria (CIU)/Chronic Spontaneous Urticaria (CSU) who remain symptomatic on H1 antihistamine treatment

NCT ID: NCT05748067 Recruiting - Clinical trials for Molar Incisor Hypomineralization

Minimally Invasive Treatment for Permanent Molars Affected With Molar-incisor Hypomineralization Defects

Start date: November 29, 2021
Phase: N/A
Study type: Interventional

In this prospective randomized clinical trial, the is aim to compare the clinical and radiographic success of 3 minimally invasive treatment protocols on permanent first molars affected with MIH over 24 months. A total of 135 children/molar teeth (N=45 per group) between the ages of 6-16 years with MIH will be recruited at the post-graduate clinics at Jordan University of Science and Technology (JUST).