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NCT ID: NCT00264160 Completed - Clinical trials for Leukemia, Myeloid, Chronic

Efficacy and Safety of Oral AMN107 in Adults With Chronic Myelogenous Leukemia Resistant and/or Intolerant to Imatinib Mesylate Therapy

Start date: May 2006
Phase: Phase 2/Phase 3
Study type: Interventional

This open-label, multicenter trial will evaluate the efficacy and safety of treatment with AMN107 in chronic myelogenous leukemia (CML) patients that are resistant and/or intolerant to imatinib mesylate therapy.

NCT ID: NCT00263289 Not yet recruiting - Vomiting Clinical Trials

Preprocedural Fasting and Nitrous Oxide -Oxygen Inhalation Analgesia for Dental Treatment of Children

Start date: January 2006
Phase: N/A
Study type: Observational

Nitrous oxide analgesia is used routinely for the dental treatment of anxious or uncooperative pediatric patients. In many instances it is used alone without any supplemental oral premedication. A controversy exists among pediatric dentists and pediatric dental departments regarding the need to apply pre-procedural fasting (PF) or other limitations on children undergoing dental treatment with nitrous oxide alone.The purpose of this study is to investigate the association between PF and the frequency of vomiting in pediatric patients receiving dental treatment with nitrous oxide analgesia.

NCT ID: NCT00263094 Completed - Headache Clinical Trials

An End to the Yom Kippur (and Ramadan) Headache

Start date: September 2004
Phase: N/A
Study type: Interventional

Fasting is a known trigger for headache. People who fast to comply with religious edict have been shown to be prone to headache which becomes more likely to occur with increasing length of fasting, and in people prone to headache. This has been documented as 'Yom Kippur Headache' and 'First of Ramadan Headache.' We performed a study to test the hypothesis that Rofecoxib, a pain medicine and anti-inflammatory, with a prolonged duration of action would prevent or attenuate headache when taken just prior to the complete (no food or drink) 25 hour fast of Yom Kippur.

NCT ID: NCT00263081 Terminated - Clinical trials for Hypercholesterolemia

Efficacy of Lapaquistat Acetate Co-Administered With Current Lipid-Lowering Treatment on Blood Cholesterol Levels in Subjects With Homozygous Familial Hypercholesterolemia

Start date: November 2005
Phase: Phase 3
Study type: Interventional

The purpose of the study is to determine the efficacy of lapaquistat acetate, once daily (QD), to lower cholesterol in subjects with homozygous familial hypercholesterolemia undergoing lipid-lowering treatment.

NCT ID: NCT00263042 Terminated - Clinical trials for Cardiovascular Disease

Comprehensive Rimonabant Evaluation Study of Cardiovascular ENDpoints and Outcomes

CRESCENDO
Start date: December 2005
Phase: Phase 3
Study type: Interventional

The primary objective is to show whether rimonabant reduces the risk of a heart attack (MI), stroke, or death from an MI or stroke in patients with abdominal obesity with other cardiovascular (CV) risk factors. The secondary objective is to show whether rimonabant reduces the risk of MI, stroke, CV death, or CV hospitalization in these patients.

NCT ID: NCT00262600 Completed - Stroke Clinical Trials

Randomized Evaluation of Long Term Anticoagulant Therapy (RE-LY) With Dabigatran Etexilate

Start date: December 2005
Phase: Phase 3
Study type: Interventional

The primary objective of this trial is to demonstrate the efficacy and safety of dabigatran etexilate in patients with non-valvular atrial fibrillation for the prevention of stroke and systemic embolism.

NCT ID: NCT00262574 Recruiting - Clinical trials for Coronary Artery Disease

Effect of BNP (Brain Natriuretic Peptides) on Endothelial Dysfunction Induced by Coronary Angioplasty

Start date: July 2005
Phase: Phase 4
Study type: Interventional

Patients receiving BNP or nitroglycerin (IV) during the angioplasty procedure. 24 h after the procedure, vascular reactivity will be re-examined using the brachial artery flow-mediated dilatation study. Blood assays for ET-1, pro-BNP, and various inflammatory markers will be checked before and 24 h after the procedure. It is our hypothesis that endothelial function will be better in the BNP treated patients compared to the NTG treated patients

NCT ID: NCT00262093 Recruiting - Pre-Eclampsia Clinical Trials

Angiogenesis Markers in Primiparas Versus Multiparas: Relevance to Preeclampsia Incidence

Start date: November 2005
Phase: N/A
Study type: Observational

The reason for having a higher incidence of preeclampsia in primiparas may involve angiogenesis imbalance in these patients.

NCT ID: NCT00261976 Completed - Psoriasis Clinical Trials

A Long-term Safety Study of Infliximab (Remicade)

Start date: February 2002
Phase: Phase 4
Study type: Observational

This is a study evaluating the long-term safety of infliximab (Remicade)

NCT ID: NCT00261937 Completed - Bronchiolitis Clinical Trials

Inhaled Furosemide Versus Placebo for Acute Viral Bronchiolitis in Hospitalized Infants

Start date: December 2005
Phase: Phase 1
Study type: Interventional

We hypothesize that inhaled Furosemide will be an effective treatment in infants with acute bronchiolitis.