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NCT ID: NCT00279201 Completed - Clinical trials for Diabetes Mellitus, Type 2

The DURABLE Trial: Evaluating the Durability of Starter Insulin Regimens in Patients With Type 2 Diabetes (IOOV)

IOOV
Start date: December 2005
Phase: Phase 4
Study type: Interventional

This study will compare insulin lispro low mixture [LM] and insulin glargine both in combination with the patient's oral diabetes medicines, for their ability to control blood sugar in patients with type 2 diabetes and compare insulin lispro LM to insulin glargine with regard to the length of time that the overall blood sugar can be controlled. This study will also determine whether the safety of insulin lispro LM and any side effects that might be associated with it are different from those observed with insulin glargine, both in combination with the patient's oral diabetes medications. The addendum study (Intensification Addendum) will compare how different insulin treatments work to control blood sugar in patients whose diabetes could not be controlled by either insulin lispro LM or insulin glargine.

NCT ID: NCT00279045 Completed - Clinical trials for Diabetes Mellitus, Type 2

Diabetes Study With Rosiglitazone Monotherapy Versus Metformin Or Glyburide/Glibenclamide

Start date: January 3, 2000
Phase: Phase 3
Study type: Interventional

The study will compare and evaluate the effects of long-term treatment of monotherapy with rosiglitazone, metformin and glyburide/glibenclamide on the improvement and maintenance of glycemic control in patients with recently diagnosed type 2 diabetes mellitus.

NCT ID: NCT00276276 Completed - Clinical trials for Lung Cancer, Small Cell

Active Symptom Control Alone Or In Combination With Oral Topotecan In Patients With Relapsed Resistant Small Cell Lung Cancer

Start date: November 2000
Phase: Phase 3
Study type: Interventional

The purpose of this study is to find out if giving oral HYCAMTIN to patients with relapsed small cell lung cancer benefits them. The study will compare how long patients live when they are given therapy to make them feel better (active symptom control) to the length of time patients live when they are also receiving oral HYCAMTIN.

NCT ID: NCT00275210 Completed - Colonic Neoplasms Clinical Trials

MOSAIC - Multicenter International Study of Oxaliplatin/ 5FU-LV in the Adjuvant Treatment of Colon Cancer

Start date: October 1998
Phase: Phase 3
Study type: Interventional

To evaluate the FOLFOX regimen versus LV5FU2 in the adjuvant treatment of stage II and III colon cancer. Primary objective: Disease Free Survival (DFS) Secondary objective: Overall Survival (OS), safety (including long term toxicity)

NCT ID: NCT00274690 Completed - Clinical trials for Postoperative Nausea and Vomiting

Post-Operative Nausea And Vomiting Study In Female Patients

Start date: February 2005
Phase: Phase 2
Study type: Interventional

The primary purpose of this study is to determine an effective dose of this NK-1 anti-emetic medication to prevent nausea and vomiting in females after surgery.

NCT ID: NCT00274326 Completed - Clinical trials for Congestive Heart Failure

DILIPO (DILutIonal HyPOnatremia)

Start date: May 2005
Phase: Phase 3
Study type: Interventional

Primary: - To assess the efficacy of SR121463B in correcting hyponatremia in patients with dilutional hyponatremia other than SIADH or cirrhosis Secondary: - To assess the long-term efficacy of SR121463B in maintaining normonatremia in these patients - To assess the safety and tolerability of SR121463B

NCT ID: NCT00271154 Completed - Heart Failure Clinical Trials

REsynchronization reVErses Remodeling in Systolic Left vEntricular Dysfunction (REVERSE)

Start date: September 2004
Phase: N/A
Study type: Interventional

Heart failure is a progressive disease that decreases the pumping action of the heart. This may cause a backup of fluid in the heart and may result in heart beat changes. When there are changes in the heart beat sometimes an implantable heart device is used to control the rate and rhythm of the heart beat. The purpose of the REVERSE clinical trial is to determine whether pacing in both the left and right ventricles using Cardiac Resynchronization Therapy (CRT) can help slow the progression of heart failure in people who have mild or previous symptoms and poor heart pumping function. This kind of therapy has previously been shown to reduce symptoms and improve exercise capacity in people with more advanced forms of heart failure.

NCT ID: NCT00269048 Completed - Atherosclerosis Clinical Trials

SB-480848 In Subjects With Coronary Heart Disease

Start date: November 2005
Phase: Phase 2
Study type: Interventional

This trial of SB-480848 in approximately 920 subjects with Coronary Heart Disease (CHD) or CHD-risk equivalent will examine whether SB-480848 produces sustained inhibition of plasma Lp-PLA2 activity, explore the effects of SB-480848 on other circulating biomarkers associated with cardiovascular risk, and evaluate the pharmacokinetics, safety and tolerability of SB-480848 over 12 weeks of once-daily oral dosing. Subjects will first be randomized 1:1 to double-blind atorvastatin 20 mg or 80 mg once daily for a minimum of 3 weeks. Subjects will then be randomized 1:1:1:1 to oral doses of SB-480848 40 mg, 80 mg, 160 mg or placebo once daily for 12 weeks. Blood samples will be collected at various timepoints. Vital signs, electrocardiograms, clinical laboratory safety tests and adverse event assessments will be performed to evaluate the safety and tolerability of SB-480848.

NCT ID: NCT00268216 Completed - Clinical trials for Pulmonary Disease, Chronic Obstructive

Survival Of Subjects With Chronic Obstructive Pulmonary Disease (COPD)

Start date: September 2000
Phase: Phase 3
Study type: Interventional

The purpose of this study is to see if fluticasone 500mcg/salmeterol 50mcg can improve the survival of subjects with COPD and also assess the long term safety profile of this drug.

NCT ID: NCT00267488 Completed - Endometrial Cancer Clinical Trials

Intravenous Weekly Topotecan In Subjects With Recurrent Or Persistent Endometrial Cancer

Start date: October 2005
Phase: Phase 2
Study type: Interventional

The purpose of this study is to find out if Hycamtin given weekly is safe and effective for treating your endometrial cancer.