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NCT ID: NCT06284772 Enrolling by invitation - Clinical trials for Cardiovascular Diseases

FINRISK 2002 Re-examination

Start date: November 13, 2023
Phase:
Study type: Observational

The project aims to fill in the existing gaps in the study of the microbiome as a cardiometabolic driver 1) by determining the key demographic, environmental, genetic, dietary, and metabolic correlates of long-term within-individual microbiome and microbial metabolite changes; and 2) by assessing how the gut microbiome, microbial metabolites, and their long-term changes are prospectively related to the risk factors, surrogate markers, and overt outcomes of CMD. To achieve this goal, repeat stool samples will be collected of ~2300 Finnish individuals who gave stool samples in the year 2002. In addition, ~300 individuals will undergo a in-depth health examination in 2024.

NCT ID: NCT06283966 Recruiting - Clinical trials for COPD (Chronic Obstructive Pulmonary Disease)

A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dosed Inhaler on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease

THARROS
Start date: February 21, 2024
Phase: Phase 3
Study type: Interventional

This study will evaluate the effect of triple ICS/LAMA/LABA therapy with BGF MDI 320/14.4/9.6 μg on cardiopulmonary outcomes relative to LAMA/LABA therapy with GFF MDI 14.4/9.6 μg in a population with COPD and elevated cardiopulmonary risk.

NCT ID: NCT06268821 Not yet recruiting - Clinical trials for Type 2 Diabetes Treated With Insulin

Effect on HbA1c of the Initiation of CGM in Adults With Type 2 Diabetes Treated With Basal Insulin in Finland

Start date: February 2024
Phase: N/A
Study type: Interventional

The goal of this clinical study is to determine the impact of starting the use of the FreeStyle Libre 2 glucose monitoring system, over a three month period, on HbA1c in adults with type 2 diabetes treated with a basal insulin regimen.

NCT ID: NCT06268782 Completed - Quality of Life Clinical Trials

The Effectiveness of an Online Exercise Program on Well-being of Postpartum Women

Start date: September 21, 2021
Phase: N/A
Study type: Interventional

The aim of this quasi-experimental study was to assess the effectiveness of a 6-week online exercise program on self-assessed quality of life (QoL), physical activity (PA), and dysfunctions of pelvic floor muscles of postpartum women immediately and 6 months after the online intervention. The data were collected with e-questionnaires. The data collection started in September 2021 and ended in September 2023.

NCT ID: NCT06262958 Recruiting - Clinical trials for Substance Use Disorders

Recognition and Early Intervention for Alcohol and Substance Abuse in Adolescence in Adolescent

REAL-SMART
Start date: August 7, 2017
Phase: N/A
Study type: Interventional

ASSIST mini-intervention is applied in an electric form in adolescent outpatients to see if it

NCT ID: NCT06261307 Not yet recruiting - Clinical trials for Language Development

Language Development Deficits and Early Interactive Music Intervention

BusyBaby
Start date: March 2024
Phase: N/A
Study type: Interventional

Investigators compare effects of 6-month music versus circus group interventions on language development in infants and toddlers with or without familial risk for dyslexia (anticipated total N=200). Effects of intervention timing, dyslexia risk and genetics, and social-emotional factors on the intervention outcomes are investigated.

NCT ID: NCT06258655 Recruiting - Anxiety Clinical Trials

The Effect of the Close Collaboration With Parents Intervention - Estonian Study

Start date: March 16, 2021
Phase: N/A
Study type: Interventional

The overall aim of the study is to implement an evidence-based intervention called 'Close Collaboration with Parents' in Estonian neonatal units. The goal of the intervention is to educate the whole multi-professional NICU staff and promote a positive change in the family-centered care culture of the units. Thus, the first aim of the study is to implement the intervention in an Estonian NICU context, in three hospitals, and study the fidelity of the intervention. More precisely, the study questions are whether adaptations are needed for the successful implementation of the intervention in the Estonian context and how feasible are the used implementation strategies. Secondly, the aim is to study the effectiveness of the Close Collaboration with Parents intervention in this context by using a quasi-experimental, pre-test - post-test, study design. The questions are whether the implementation of the intervention in the Estonian setting will result in positive effects such as 1) an improved development environment for the infants during hospital stay (less noise, more parental speech, and more parent-infant physical closeness), 2) intensified parental bonding to the infant, and 3) increased parental confidence and emotional well-being at the time of discharge from hospital.

NCT ID: NCT06258109 Recruiting - Clinical trials for Pregnancy Complications

Risk of Recurrent CeAD After Pregnancy

LONG-RECAP
Start date: January 1, 2023
Phase:
Study type: Observational

Primary objective: To determine whether pregnancy increases the risk of recurrent CeAD and delayed stroke in women with prior CeAD based on long-term data. Methods: Multicentric, observational case-control study based on pooled individual patient data from several stroke centers. Primary endpoint: Primary composite outcome measure includes the following outcomes: (i) occurrence of recurrent CeAD, (ii) occurrence of ischemic or hemorrhagic stroke, (iii) death.

NCT ID: NCT06253728 Recruiting - Clinical trials for Overweight and Obesity

A Study of Biochemical Response to Alternative Proteins

COBRA
Start date: January 18, 2024
Phase: N/A
Study type: Interventional

The overall objective of this research is to determine the digestive faith and health impact of protein and fiber rich foods in different food matrices in type 2 diabetes risk population. This is achieved by controlled postprandial intervention where plasma amino acids, lipids, glucose metabolism, bile acids and microbial metabolites are evaluated as well as fecal microbiota and metabolites.

NCT ID: NCT06250413 Not yet recruiting - Clinical trials for Microbial Colonization

Autoflor -Lyophilized Capsulated Autological FMT to Restore Gut Microbiome After Treatment With Antibiotics

FMT
Start date: February 2024
Phase: N/A
Study type: Interventional

In this clinical trial, our aim is to assess the effect of auto-FMT (Fecal microbiome transplantation) on the intestinal microbiota, after a course of antibiotics. 30 healthy adults are recruited. All are given a five day course of amoxicillin-clavulanate. The subjects are double blinded and randomized to two groups. Group A is given autologous FMT (auto-FMT) on day 7 (two days after the end of the course of antibiotics) and Group B is given auto-FMT on day 28 (23 days after the end of the course of antibiotics).