Clinical Trials Logo

Autism Spectrum Disorder clinical trials

View clinical trials related to Autism Spectrum Disorder.

Filter by:

NCT ID: NCT03771560 Completed - Clinical trials for Autism Spectrum Disorder

Folinic Acid in Autism

Start date: February 15, 2018
Phase: Phase 2/Phase 3
Study type: Interventional

An examination of changes in urinary metabolites with use of folinic acid in children with autism spectrum disorder (ASD). Investigators will also measure behavioral measures and academic measures monthly at school with teachers and parents report.

NCT ID: NCT03771001 Recruiting - Clinical trials for Autism Spectrum Disorder

5Minutes4Myself: A Wellness Program for Caregivers

Start date: November 2015
Phase: N/A
Study type: Interventional

This research study refines a wellness program designed for caregivers of autistic children called 5Minutes4Myself and further investigates its feasibility. Participants will attend a workshop to consent, participate in focus groups on lifestyle issues, and complete a baseline survey. Participants will have an individualized consultation with a coach to develop their tailored wellness program and be introduced to an app that support habits to build wellness activities into their daily life. The app provides the participant with their goal profile, tailored reminders, weekly check-ins, and delivers a micro-mindfulness program. Coaches will check-in monthly with participants and work together to modify their program as desired. After 4-6 months, participants will gather for a closing workshop to discuss their lifestyle and to evaluate the program. Pre-/post-surveys will examine health, well-being, stress, depression, and mindfulness. The app usability will be assessed using the Modified Systems Usability Scale (MSUS) as well as usage data.

NCT ID: NCT03769571 Recruiting - Clinical trials for Autism Spectrum Disorder

Generalized Training Program for Caregivers on the ESDM: PEGASE

Start date: November 8, 2018
Phase: N/A
Study type: Interventional

The main objective of the study is to evaluate the effectiveness of a parent's training program (name PEGASE) of young children (aged 2 to 4 years) with Autism Spectrum Disorders. This study is follow up by the Autism Resource Center PACA (CRA PACA), which is located in Marseille's university Department of Child Psychiatry. This center is a regional expert center in diagnostic and research missions in the field of Autism. The center is promoting new advances in the field of Autism Spectrum Disorders (ASD) The center receives requests for diagnostic assessment from all the region. Autism is to date a major public health problem, current prevalence rates are 1 child / 88 in the United States. This prevalence continues to increase. Autism is a severe neurodevelopment disorder with significant functional impact. An essential axis in the field of health is to develop new treatment strategy including low costs and family impact particularly in quality of life. In France, consensus guidelines (HAS 2012) on the diagnosis assessment for Autism Spectrum Disorders (ASD) people and interventions were edited. Support for grade recommendations have been issued. In this research, the investigators focus on a global, early and coordinated management method: the Early Start Denver Model. This intervention obtained a grade B to the recommendations of the HAS in 2012. Early Start Denver Model (ESDM) is scientifically proven by a lots of studies. Two management modalities are discuss in the ESDM model: the classical ESDM and the ESDM P (parents ESDM). Even if in both ways of care, the parent is put in a central position around the care of the child. In P ESDM, the parent is trained in the techniques of ESDM itself. This parental coaching program at ESDM (P-ESDM) was developed by Rogers et al at Sacramento Davis University. P ESDM is not yet developed in France and has not been the subject of any French-language publication to date. This program is dedicated to young parents of children with autism spectrum disorders aged between 2 and 4 years old. This is a 7-month program (with a duration of inclusion of 3 year). The program is based on ESDM techniques, it meets both the need to include parents in care and the idea of reducing the cost of these care (need fewer hours of care by professionals). This program is offered to all parents of autism spectrum disorders children between the ages of 2 and 4 who go to CRA PACA for an expert diagnostic evaluation. The aim of this study is to objectify the effectiveness of this parental intervention in a French population.

NCT ID: NCT03757585 Not yet recruiting - Clinical trials for Autism Spectrum Disorder

Management of Emotional Dysregulation in Youth With Non-verbal Learning Disability (NVLD) and/or Autism Spectrum Disorders (ASD) Using Telepsychiatry of Complementary and Alternative Treatments

Start date: December 2018
Phase: Phase 4
Study type: Interventional

This study consists of a 6-week, open-label, randomized clinical trial study to compare efficacy and tolerability of the natural treatments omega-3 fatty acids, inositol, and N-Acetyl Cysteine (NAC) in the treatment of mood dysregulation in children and adolescents with non-verbal learning disability (NVLD) or Autism Spectrum Disorder (ASD). Subjects will include youth ages 5-17 years with a non-verbal learning disability (NVLD) or autism spectrum disorder (ASD) and current symptoms of emotional dysregulation.

NCT ID: NCT03751930 Not yet recruiting - Clinical trials for Autism Spectrum Disorder

Intestinal Microbiota, Tryptophan and Autism

Start date: December 2018
Study type: Observational

Autism Spectrum Disorder refers to complex neuro-developmental disorders that affect social communication and behavioral adaptation. Currently, the diagnosis of Autism Spectrum Disorder is based on a clinical examination that is performed classically during the first three years of life. The heterogeneity of the disorders occurring in autism make pathologies difficult to diagnose and manage. The overall goal of this project is the identification of metabolic biomarkers based on clinical profile. The best characterization of physiopathological pathways will ultimately allow the identification of subgroups of subjects and facilitate the development of targeted therapeutics. The proposed work aims to test the hypothesis of a disruption of tryptophan metabolism in Autism Spectrum Disorder via the gut microbiota.

NCT ID: NCT03735888 Not yet recruiting - Clinical trials for Autism Spectrum Disorder

An Open-Label Pilot Study of Esomeprazole in Children With Autism

Start date: November 2018
Phase: Phase 2
Study type: Interventional

Autism is a pervasive developmental disorder characterized by core deficits in social behavior and communication and the presence of repetitive/stereotyped behaviors. The objective of the study is to evaluate the efficacy of Esomeprazole as a treatment for social communication deficits in children with Autism Spectrum Disorder (ASD). This prospective 12 week open-label study will invite 25 children with ASD between the ages of 2 and 6 years of age to participate.

NCT ID: NCT03730194 Not yet recruiting - Clinical trials for Attention Deficit Hyperactivity Disorder

A SMART Design to Improve Sleep Disturbance in Adolescents With Neurodevelopmental Disorders

Start date: December 2018
Phase: N/A
Study type: Interventional

The objective of this study is to pilot a sequential, multiple assignment, randomized trial (SMART) design to compare the impact of a sequence of sleep interventions, based on participant treatment response, to optimize sleep health in adolescents 10-18 years of age with neurodevelopmental disorders (NDDs).

NCT ID: NCT03725644 Completed - Clinical trials for Autism Spectrum Disorder

Parent Training Program for Preschool Children With Autism Spectrum Disorders

Start date: January 29, 2015
Phase: N/A
Study type: Interventional

Previous research has showed that parent-training programs derived from the developmental individual-difference relationship-based model (DIR) could improve the communicative development of children with autism spectrum disorder (ASD). However, the empirical evidence is weak. This study therefore examines whether a DIR-based parent-training program can improve children's adaptive functioning and parents' parenting skills using a rigorous randomized controlled trial design with a dose-matched control group. Forty preschool children with autism spectrum disorder (ASD) and their parents were randomly assigned to the parent-training program group or the traditional program group at the pre-test phase. Both groups received 14-week intervention programs and were assessed using pre- and post-tests. Children's development levels and adaptive functioning were assessed by the Functional Emotional Assessment Scale (FEAS), the Chinese version of Psychoeducational Profile-third edition (CPEP-3), and the Vineland Adaptive Behavior Scales (VABS). In addition, parents' parenting skills were assessed by the FEAS and parenting stress was evaluated by the Parenting Stress Index-Short Form.

NCT ID: NCT03724552 Recruiting - Clinical trials for Autism Spectrum Disorder

Photobiomodulation in Autism Spectrum Disorder (ASD)

Start date: April 13, 2017
Phase: N/A
Study type: Interventional

The purpose of this 8-week open-label study is to assess the tolerability, safety, and efficacy of Transcranial LED Therapy in patients with Autism Spectrum Disorder (ASD). The investigators propose to enroll up to 30 subjects of both genders ages 18-59 years with intact intellectual functions who meet the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria for Autism Spectrum Disorder (ASD). Participation requires treatment sessions at Massachusetts General Hospital (MGH) twice weekly for eight weeks, totaling 16 visits. Each session lasts approximately 45 minutes. During the treatment session, the subject will lie down comfortably on an exam bed. Subjects will also be asked to complete a series of self-report questionnaires related to their symptoms and quality of life.

NCT ID: NCT03724136 Recruiting - Alzheimer Disease Clinical Trials

Alzheimer's Autism and Cognitive Impairment Stem Cell Treatment Study

Start date: October 24, 2018
Phase: N/A
Study type: Interventional

The purpose of the study is to evaluate the use of autologous Bone Marrow Derived Stem Cells (BMSC) as a means to improve cognitive impairment as occurs in Alzheimer's Disease and other dementias and to improve behavior and socialization issues which occur in adult Autism Spectrum Disorder. The use of Near Infrared Light, in conjunction with the use of BMSC, will also be assessed.