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Autism Spectrum Disorder clinical trials

View clinical trials related to Autism Spectrum Disorder.

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NCT ID: NCT03583684 Not yet recruiting - Clinical trials for Autism Spectrum Disorder

Neuroimaging Predictors of Improvement to Pivotal Response Treatment (PRT) in Young Children With Autism

PRT-I
Start date: August 1, 2018
Phase: N/A
Study type: Interventional

Autism spectrum disorder (ASD) is a very heterogeneous disorder with limited empirically validated behavioral and biological interventions. The goal of this pilot investigation is to apply a biologically-based approach to identify predictors of treatment response in children with ASD who are receiving Pivotal Response Treatment (PRT), an evidence-based behavioral intervention. Specifically, the investigators propose to identify neuroimaging biomarkers of treatment response to a PRT program (PRT-P) targeting language deficits in young children with ASD who will be randomized to either PRT-P or to a delayed treatment group (DTG).

NCT ID: NCT03575429 Not yet recruiting - Clinical trials for Autism Spectrum Disorder

Autism Adaptive Community-based Treatment to Improve Outcomes Using Navigators (ACTION) Network

Start date: August 15, 2018
Phase: N/A
Study type: Interventional

The Autism Adaptive Community-based Treatment to Improve Outcomes Using Navigators (ACTION) Network—a new interdisciplinary network of 6 institutions—will blend clinical effectiveness and implementation research designs to study individual and combined effects of 2 evidence-based interventions in real world settings. The first is to engage families to access resources and support when they first learn their child has signs of ASD using an evidence-based intervention that integrates motivational interviewing and problem-solving education (MI+PSE). The second is to coach families to embed evidence-based intervention strategies for toddlers with ASD in everyday activities using the Early Social Interaction (ESI) model. In Phase 1, investigators will compare the effectiveness of adaptive interventions that use MI+PSE with and without ESI on parent and child outcomes in 3 sites in Florida and Massachusetts using a 2-stage Sequential Multiple Assignment Randomized Trial (SMART) design. In Phase 2, investigators will construct an adaptive intervention to optimize the effects and study the feasibility of implementation in new sites in California. This research network can build the capacity of community-based systems to provide earlier and widespread access to cost-efficient, community-viable treatment and be ready for immediate and rapid implementation across the US.

NCT ID: NCT03573128 Enrolling by invitation - Clinical trials for Autism Spectrum Disorder

Development and Pilot Testing of the Students With Autism Accessing General Education (SAAGE) Model

SAAGE
Start date: August 1, 2017
Phase: N/A
Study type: Interventional

Study personnel will use evidence based behavioral skills training procedures to coach educators to implement modules designed to increase the quality of educational services and access to inclusive settings in elementary school for students with Autism Spectrum Disorder.

NCT ID: NCT03570372 Not yet recruiting - Clinical trials for Autism Spectrum Disorder

Internet-based Treatment for Adults With Autism Spectrum Disorder (iALMA)

iALMA
Start date: August 1, 2018
Phase: Early Phase 1
Study type: Interventional

The group of patients diagnosed with Autism spectrum disorder (ASD) is increasing and so is the need for new and effective treatment methods. ASD is characterized, among other things, by difficulties in social interaction and communication. These difficulties often affects their quality of life and causes a risk of developing social anxiety or other forms of mental illness, which often leads to isolation and may cause difficulties in participating in regular face- to- face psychological treatment. Although research shows that group therapy is favorable for this group of patients, many with ASD refrain from group-treatment due to social anxiety or difficulties with public transport. In order to increase the availability of evidence based psychological treatment for these patients, it seems important to be able to offer a web-based treatment option, with the ability to participate in online group sessions. The aim of the study is to investigate whether Internet-based CBT is an effective method of raising the quality of life and improving the mental health of adults with ASD. A randomized controlled study design will be used. Assessment will be conducted through video interviews, recruiting 84 patients with ASD and normal intellectual abilities. Symptoms of depression and other forms of psychopathology will be assessed through MINI-7 interviews. Primary outcome measures are quality of life and symptoms of depression and anxiety. Participants in the intervention group receives a 37 session blended treatment combining individual ICBT delivered through a treatment platform called Stöd och Behandling (SOB) with the opportunity to participate in regular group discussions delivered through a discussion forum online. Participants in the control groups are offered self-studies through psycho educative books about ASD. Data will be collected at baseline, mid-treatment, post-treatment and after six and 12 months.

NCT ID: NCT03569176 Completed - Clinical trials for Autism Spectrum Disorder

Examining the Efficacy of a Mobile Therapy for Children With Autism Spectrum Disorder

Start date: November 1, 2016
Phase: N/A
Study type: Interventional

The purpose of this research is to study the effects of a novel artificial intelligence (AI) tool for automatic facial expression recognition that runs on Google Glass through an Android app to deliver social emotion cues to children with autism during social interactions. This novel device will use a camera, microphone, head motion tracker to analyze the behavior of the subject during interactions with other people. The system is designed to give participants non-interruptive social cues in real-time and will record social responses that can later be used to help aid behavioral therapy. It is hypothesized that the system's ability to provide continuous behavioral therapy during social interactions will enable faster gains in social skills.

NCT ID: NCT03560453 Completed - Clinical trials for Autism Spectrum Disorder

Facilitating Employment for Youth With Autism

Start date: August 1, 2013
Phase: N/A
Study type: Interventional

This study will test the efficacy of a nationally recognized employment training and placement program (Project SEARCH) when applied to youth with Autism Spectrum Disorders. It is designed to examine a single overall research question: Research Question: To what extent does a collaborative, employer-based employment training and placement program improve the employment outcomes, need for support, social responsiveness, self-determination, and quality of life of young adults with ASD 18-21 served in public special education programs?

NCT ID: NCT03560297 Recruiting - Clinical trials for Autism Spectrum Disorder

SeRenade Parent-Child Music Class Program

Start date: May 15, 2018
Phase: N/A
Study type: Interventional

This pilot study examines the impact of the SeRenade Parent-Child Music Class Program, which emphasizes parent training, peer inclusion, and musical play combined with established behavioral techniques, on the development of child social engagement, positive behavior, and parental well-being.

NCT ID: NCT03556826 Not yet recruiting - Clinical trials for Autism Spectrum Disorder

Social Value Training in Toddlers With Elevated Autism Symptoms

SVT
Start date: July 1, 2018
Phase: N/A
Study type: Interventional

In the proposed pilot study, ASD+ toddlers will undergo Social Value Training (SVT) using a gaze-contingent eye-tracking paradigm in toddlers with elevated symptoms of ASD (ASD+) (n=48). SVT will be administered over a two-day period and the training effects will be assessed by changes in visual attention to high-value (HV) faces as compared to low-value (LV) faces between baseline, post-baseline, and a follow-up assessment using two tasks: a laboratory selective attention (LSA) task and real-world selective attention (RWSA) task. The investigators will also evaluate acceptability and feasibility of the value training and contribution of sex, nonverbal developmental level, and severity of autism symptoms to response to the training.

NCT ID: NCT03553875 Not yet recruiting - Clinical trials for Autism Spectrum Disorder

Memantine for the Treatment of Social Deficits in Youth With Disorders of Impaired Social Interactions

Start date: June 2018
Phase: Phase 3
Study type: Interventional

This study is a 12-week randomized-controlled trial of memantine hydrochloride (Namenda) for the treatment of social impairment in youth with Non-Verbal Learning Disorder, High-Functioning Autism Spectrum Disorder, and related conditions. Eligible participants will be males and females ages 8-18. This study consists of up to 6 visits to Massachusetts General Hospital.

NCT ID: NCT03550209 Enrolling by invitation - Clinical trials for Autism Spectrum Disorder

Fatty Acid Supplementation in Children With ASD

Omega Heroes
Start date: June 28, 2018
Phase: Phase 2
Study type: Interventional

The purpose of this study is to examine how fatty acid supplementation alters biological signatures in children with ASD