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NCT ID: NCT06045494 Active, not recruiting - H. Pylori Infection Clinical Trials

The Efficacy of Treatment for Helicobacter Pylori Infection in Preschooler by Yoghurt With LG21

Start date: September 26, 2023
Phase: N/A
Study type: Interventional

The goal of this randomized, open-label, interventional trial is to study the efficacy of treatment for Helicobacter Pylori Infection in Preschooler aged 4-6 by Meiji Yoghurt with LG21. The main question it aims to answer is: - whether the treatment by Meiji Yoghurt LG21 is effective by stool antigen (HpSA) test 140 qualified participants will be enrolled and randomized into 2 groups of the same size (product study group and blank control group). Participants of the product study group will need to eat assigned Meiji Yoghurt for 12 weeks, one bottle each day, while participants of the blank control group won't receive any intervention during the study. Four visits will be made for all participants, and relevant clinical data will be captured and recorded into CTMS (Clinical Trial Management System) for statistical analysis and reporting.

NCT ID: NCT06045403 Active, not recruiting - Hypertension Clinical Trials

Health Monitoring of Elderly Hypertensive Patients

Start date: June 15, 2023
Phase:
Study type: Observational

This study aims to monitor the health of elderly hypertensive patients in Tianjin.

NCT ID: NCT06045364 Active, not recruiting - Nausea and Vomiting Clinical Trials

Effect of Glycopyrrolate on Nausea and Vomiting After ERCP Operation

Start date: October 1, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

This study aims to determine the role of Glycopyrrolate in preventing postoperative nausea and vomiting of ERCP.

NCT ID: NCT06045299 Recruiting - Presbyopia Clinical Trials

Evaluation of the Efficacy and Safety of LNZ101 and LNZ100 for the Presbyopia

Start date: September 27, 2023
Phase: Phase 3
Study type: Interventional

Phase 3 Evaluation of the Efficacy and Safety of LNZ101 and LNZ100 for the Treatment of Presbyopia

NCT ID: NCT06045286 Recruiting - Clinical trials for Colorectal Liver Metastases

High- and Low-dose Radiotherapy Combined With PD-1 Inhibitors for MSS CRLM

HaRyPOT
Start date: September 20, 2023
Phase: Phase 1
Study type: Interventional

This pilot phase I trial aims to investigate the efficacy and safety of high- and low-dose radiotherapy combined with programmed cell death-1 (PD-1) inhibitors in microsatellite stable (MSS) metastatic colorectal cancer (mCRC) that have failed second-line immunotherapy or above.

NCT ID: NCT06045221 Recruiting - Type 2 Diabetes Clinical Trials

A Study of Orforglipron (LY3502970) Compared With Semaglutide in Participants With Type 2 Diabetes Inadequately Controlled With Metformin

ACHIEVE-3
Start date: September 22, 2023
Phase: Phase 3
Study type: Interventional

The main purpose of this study is to assess efficacy and safety of orforglipron compared with oral semaglutide in participants with Type 2 diabetes and inadequate glycemic control with metformin.The study will last around 61 weeks.

NCT ID: NCT06045156 Recruiting - Clinical trials for Acute Ischemic Stroke

Early Tirofiban Administration After Intravenous Thrombolysis in Acute Ischemic Stroke

Start date: April 10, 2024
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the efficacy and safety of early tirofiban administration in patients undergoing IVT

NCT ID: NCT06045091 Recruiting - Multiple Myeloma Clinical Trials

To Evaluate the Safety and Efficacy of Human BCMA Targeted CAR-NK Cells Injection for Subjects With R/R MM or PCL

Start date: July 4, 2023
Phase: Early Phase 1
Study type: Interventional

This study is a single-arm, open-label, dose-escalation trial to explore the safety, tolerability and pharmacokinetic/pharmacodynamics characteristics of human BCMA targeted CAR-NK Cells injection, and to preliminarily observe the efficacy of the trial drug in patients with relapsed/refractory multiple myeloma or plasma cell leukemia.

NCT ID: NCT06045039 Recruiting - Clinical trials for Cardiovascular Diseases

Clinical Efficacy of Stent-balloon-stent (SBS) Technique in the Treatment of Coronary Bifurcation Lesions

Start date: January 1, 2023
Phase:
Study type: Observational

The treatment of coronary bifurcation lesions continue to remain challenges. Due to the special hemodynamics caused by the special anatomical structure of the coronary bifurcation, it is easy to cause vascular crest displacement and plaque formation. The existing single-stent strategy and double-stent strategy are easy to cause vascular crest offset, stent accumulation, in-stent thrombosis, in-stent restenosis and other poor long-term prognosis. Stent-balloon-stent (Stent-balloon-stent, SBS) technique enables the guide wire to enter the side branch from the mesh at the distal end of the main vascular stent, and the drug balloon is used to dilate the opening of the side branch, so that the opening area of the side branch is more than 5mm².The SBS technique reduces the risk of branch vascular dissection, occlusion, snow shoveling phenomenon, maintain the original state of bifurcated blood vessels to the greatest extent, should have a good impact on the long-term prognosis of patients with coronary bifurcation lesions (CBL). The purpose of this study is to explore the feasibility, safety and effectiveness of SBS technique.

NCT ID: NCT06044558 Completed - Clinical trials for Kidney Transplant Patients

Effect of Azole/Echinocandin Use on Tacrolimus Pharmacokinetics

Start date: September 1, 2022
Phase:
Study type: Observational

The purpose of this observational study is to analyze the extent and characteristics of drug interactions (focusing on azole antifungals and echinocandins) and genetic polymorphisms on tacrolimus blood concentrations in renal transplant recipients in order to provide a reference for the appropriate adjustment of tacrolimus dosing regimen to reduce the incidence of adverse drug reactions and rejection, and to improve the survival of transplanted kidneys.