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NCT ID: NCT05576415 Completed - Dry Eye Disease Clinical Trials

Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of OC-01 in Adult Chinese With Dry Eye Disease

Start date: December 7, 2022
Phase: Phase 1
Study type: Interventional

The objective of this study is to evaluate the pharmacokinetics (PK) in adult Chinese subjects with dry eye disease (DED)1 after bilateral nasal spray administration of OC-01 (varenicline solution) Nasal Spray at a concentration of 0.6 mg/mL.

NCT ID: NCT05576298 Completed - Type 2 Diabetes Clinical Trials

A Clinical Study Comparing the Pharmacokinetics and Pharmacodynamic Characteristics of Insulin Degludec Injection (RD15003) and Insulin Degludec Injection (Tresiba®) in Healthy Subjects

Start date: October 8, 2021
Phase: Phase 1
Study type: Interventional

To evaluate the single-dose subcutaneous injection of insulin degludec injection (Tresiba®) listed by Novo Nordisk in China as a reference drug, the insulin degludec injection provided by Dongguan Dongyang Sunshine Biopharmaceutical R&D Co., Ltd. (RD15003) pharmacokinetics and pharmacodynamic characteristics in healthy subjects, and then to evaluate the bioequivalence of test drugs and control drugs.

NCT ID: NCT05576168 Completed - Clinical trials for Beta Cell Dysfunction

Related Mechanisms of RBP4 in Glycolipid Metabolism

Start date: May 1, 2018
Phase: N/A
Study type: Interventional

Retinol binding protein 4 ( RBP4 ) is a newly discovered adipokine secreted by adipose tissue, which leads to insulin resistance ( IR ) and participates in the occurrence of T2DM. At present, it's not clear whether RBP4 can cause islet β cell dysfunction. The purpose of this study is to explore the role of serum apo-RBP4 in the pathogenesis of newly diagnosed T2DM patients.

NCT ID: NCT05574985 Completed - COVID-19 Clinical Trials

Recombinant Omicron-Delta COVID-19 Vaccine (CHO Cell)

Start date: August 29, 2022
Phase: N/A
Study type: Interventional

Popular topic:A Clinical Study of Recombinant Omicron-Delta COVID-19 Vaccine (CHO Cell) Overall design:The study was designed as a randomized, open and controlled study. Study population: People aged 18 years and above and 6-15 months after the completion of basic immunization or 6-9 months after the completion of enhanced immunization with the new coronal prototype vaccine. Test groups:Study group;Control group;Observation group ①;Observation group ②

NCT ID: NCT05574894 Completed - Growth Hormone Clinical Trials

Effect of GH Supplementation on the Blastocyst Euploid Rate in AMA Patients--A Retrospective Cohort Study

Start date: January 1, 2021
Phase: Phase 3
Study type: Interventional

This retrospective cohort study aims to investigate the effects of recombinant human growth hormone (rh-GH) on the euploid status of preimplantation blastocysts in AMA patients. Infertile patients aged 38-46 years old were recruited for study if they fulfill the inclusion criteria and do not have the exclusion criteria. Treatment group: Women received growth hormone (GH) supplement during antagonist protocol for ovarian stimulation. Control group: Women received antagonist protocol for ovarian stimulation. The primary outcome is the euploidy rate of blastocysts per stimulation cycle and per testing cycle.

NCT ID: NCT05574543 Completed - Clinical trials for Degenerative Disc Disease

A Phase I/II Study of AGA111 for Lumbar Interbody Fusion in Patients With Degenerative Disc Disease

Start date: December 1, 2020
Phase: Phase 1/Phase 2
Study type: Interventional

The objectives of the study are to evaluate the safety and preliminary efficacy of a single administration of AGA111 for lumbar interbody fusion in patients with degenerative disc disease.

NCT ID: NCT05573399 Completed - Clinical trials for Pancreatoduodenectomy

Early Oral Feeding for Patients After Pancreaticoduodenectomy

Start date: August 1, 2018
Phase:
Study type: Observational

This study intends to retrospectively analyze the patients who underwent pancreatoduodenectomy and compare the safety and feasibility between early enteral nutrition through nasojejunal tube and early oral feeding after pancreatoduodenectomy. This study is expected to revise the guidelines for early nutritional support after pancreaticoduodenectomy, reduce postoperative complications, and provide better guidance for clinical work.

NCT ID: NCT05573178 Completed - Syncope, Vasovagal Clinical Trials

Different Catheter Ablation Strategy in Vasovagal Syncope

Start date: December 26, 2020
Phase: N/A
Study type: Interventional

This study is a prospective, single-center randomized controlled clinical trial. patients with refractory vasovagal syncope were randomly divided into two groups according to the proportion of 1:1. Group A: simple left atrial ganglion plexus ablation (RAGP + LSGP + LLGP + LIGP + RIGP ablation); B group: left atrial ganglion plexus combined with right atrial ganglion plexus ablation (group A + consolidation ablation of RAGP at the junction of right atrial septum and superior vena cava). To clarify the role of RAGP in cardiac autonomic nervous system and the effect of ablation, to establish the standard stragtegy of cardiac nerve ablation.

NCT ID: NCT05572645 Completed - Breast Cancer Clinical Trials

Pyrotinib Plus Trastuzumab Versus Pertuzumab Plus Trastuzumab

Start date: October 1, 2022
Phase:
Study type: Observational

Pyrotinib Plus Trastuzumab Versus Pertuzumab Plus Trastuzumab

NCT ID: NCT05570435 Completed - Healthy Clinical Trials

Efficacy of Milk Product Supplemented With Bioactives in Lowering Post Meal Glucose Response

Start date: November 16, 2022
Phase: N/A
Study type: Interventional

This is a monocentric, randomized controlled, open-label, 2x2 cross-over study. The main objective of the study is to Evaluate the efficacy of Nestle YIYANG TangLv milk powder in lowering the Post Prandial Glucose Response (PPGR) of a high carbohydrate meal when consumed with the meal.