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NCT ID: NCT00134290 Completed - Insulin Resistance Clinical Trials

The Effects of Calorie Restriction With or Without Metformin on Weight and Insulin Resistance

Start date: January 2002
Phase: Phase 4
Study type: Interventional

This is a study to: - Determine the difference between strong hypo-energetic "standard diet advice" and modest hypo-energetic "personal diet advice"; and - Determine the influence of insulin-insensitivity on obesity and weight reduction by treating patients with metformin or placebo.

NCT ID: NCT00134277 Completed - Clinical trials for Intermittent Claudication

Trial Comparing Different Medical Devices for Infragenual Dilatation

Start date: September 2004
Phase: N/A
Study type: Interventional

This study is a comparison of different medical devices for infragenual dilatation.

NCT ID: NCT00134173 Completed - Coronary Disease Clinical Trials

A Coronary IVUS Study to Compare Torcetrapib/Atorvastatin to Atorvastatin Alone in Subjects With Coronary Heart Disease

ILLUSTRATE
Start date: October 2003
Phase: Phase 3
Study type: Interventional

The Torcetrapib project was terminated on December 2, 2006 due to safety findings. To look at ultrasound images taken in the blood vessels of the heart and to look at various lipids in the blood of people with known coronary heart disease

NCT ID: NCT00133978 Completed - Sepsis Clinical Trials

Trial of Glutamine and Antioxidant Supplementation in Critically Ill Patients

REDOXS
Start date: April 2005
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether providing high dose glutamine and antioxidants to critically ill patients will be associated with improved survival.

NCT ID: NCT00133835 Completed - Pancreatitis Clinical Trials

Comparison of ESWL Alone and ESWL + Endoscopy for Painful Chronic Pancreatitis

Start date: March 1998
Phase: Phase 1/Phase 2
Study type: Interventional

Endoscopy is an established method of treatment for painful obstructive calcified pancreatitis. It involves the disintegration of calcifications using extracorporeal shock wave lithotripsy (ESWL) followed by endoscopic removal of stone fragments possibly associated with stent insertion. A pilot study suggests that ESWL alone relieves pain in calcified chronic pancreatitis (CP). The aim of this study is to compare both techniques in a randomized controlled trial.

NCT ID: NCT00133731 Completed - Clinical trials for Angioplasty, Transluminal, Percutaneous Coronary

The SEPIA-PCI Trial: Otamixaban in Comparison to Heparin in Subjects Undergoing Non-Urgent Percutaneous Coronary Intervention

SEPIA-PCI
Start date: September 2004
Phase: Phase 2
Study type: Interventional

The objective of this dose-ranging study is to determine the effects of several intravenous (IV) regimens of otamixaban on pharmacodynamic markers (including markers of thrombosis and coagulation markers), safety/tolerability, clinical efficacy and pharmacokinetics.

NCT ID: NCT00132938 Completed - Chronic Bronchitis Clinical Trials

PERSPECTIVE: Telithromycin - Acute Exacerbation of Chronic Bronchitis

Start date: January 2004
Phase: Phase 4
Study type: Interventional

Primary Objective: - The primary objective of the study is to demonstrate the superiority of telithromycin over azithromycin and over cefuroxime axetil in the reduction of Streptococcus pneumoniae (Sp) strains resistant to beta-lactams or macrolides at the Test of Cure (TOC) visit in the sputum of patients with Sp detected at the start of the study (Visit 1). Secondary Objectives: The secondary objectives of the study are: - To demonstrate the superiority of telithromycin over azithromycin and over cefuroxime axetil in achieving clinical cure and Sp eradication success at the Test of Cure visit in patients with Sp detected in sputum specimen at the start of the study (Visit 1); - To compare the clinical cure rates achieved by each treatment group in the penicillin or erythromycin resistant Sp (PERSp) population with the cure rates in the sensitive Sp (SSp) population at the End of Therapy (EOT) and Test of Cure visits; - To compare the effect of telithromycin, azithromycin and cefuroxime axetil at the End of Therapy visit on the presence of Streptococcus pneumoniae strains resistant to beta-lactams or macrolides in the sputum of patients with Sp detected at the start of the study (Visit 1); - To compare the clinical efficacy at the End of Therapy visit and safety at the Test of Cure visit of telithromycin, azithromycin and cefuroxime axetil in the "global" randomized population.

NCT ID: NCT00131352 Completed - Clinical trials for Osteoarthritis, Knee

A Study of the Safety and Efficacy of Hylan G-F 20 (Synvisc) in Patients With Symptomatic Osteoarthritis of the Knee

Start date: May 2005
Phase: Phase 3
Study type: Interventional

This clinical study is to evaluate the safety and efficacy of hylan G-F 20 (Synvisc) in patients with symptomatic knee osteoarthritis (OA). Patients will be given 6 mL of hylan G-F 20 (Synvisc) (or a phosphate buffered saline control), with a possible repeat treatment with Synvisc after the week 26 visit.

NCT ID: NCT00131066 Completed - Psoriasis Clinical Trials

Long-Term Follow-Up Study of Psoriasis Patients

Start date: August 2002
Phase: N/A
Study type: Observational

The purpose of this study is to evaluate the long-term safety and profile of psoriasis patients who have completed participation in a previous study and who received treatment with MEDI-507.

NCT ID: NCT00130403 Completed - Clinical trials for Osteoporosis, Postmenopausal

OPTAMISE: Clinical Effectiveness of Teriparatide After Alendronate or Risedronate Therapy in Osteoporotic Postmenopausal Women

Start date: March 2004
Phase: Phase 4
Study type: Interventional

To determine how prior therapy with alendronate or risedronate in postmenopausal women with osteoporosis influences the clinical effectiveness of teriparatide; The primary objective of the study is to compare the teriparatide (human, recombinant PTH[1-34])-associated change from baseline in a marker of bone formation, N-terminal propeptide of type I collagen (P1NP), between subjects previously treated with risedronate and those previously treated with alendronate.