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NCT ID: NCT03314935 Not yet recruiting - Clinical trials for Recurrent Ovarian Carcinoma

A Phase 1/2 Study of INCB001158 in Combination With Chemotherapy in Subjects With Solid Tumors

Start date: December 20, 2017
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this open-label nonrandomized Phase 1/2 study is to evaluate INCB001158 in combination with chemotherapy in participants with advanced/metastatic solid tumors.

NCT ID: NCT03314870 Recruiting - Breast Cancer Clinical Trials

Development of a Response Signature to Neoadjuvant Chemotherapy for Breast Cancer

Breast-sign
Start date: August 7, 2017
Phase: N/A
Study type: Interventional

Breast cancer is the most frequent cancer in women. It is often treated with neoadjuvant chemotherapy, administered before surgical resection. Unfortunately, many patients do not respond to this treatment, or only respond partially. Clinicians therefore need predictive biomarkers of treatment response. Thanks to an innovative technique, called CATS, this study aims at identifying blood and tissue biomarkers which are predictive of response to chemotherapy.

NCT ID: NCT03314558 Not yet recruiting - COPD Clinical Trials

Has Pulmonary Rehabilitation a Positive Impact on Sleep Quality in Patients Suffering From COPD ?

Start date: November 15, 2017
Phase: N/A
Study type: Observational

The purpose of our study is to assess the impact of pulmonary rehabilitation on objective sleep quality in COPD patients.

NCT ID: NCT03314467 Recruiting - Clinical trials for Obstructive Sleep Apnea

Role of Obstructive Sleep Apnea Syndrome in the Occurrence of Diabetic Retinopathy in Type 2 Diabetes.

Start date: October 6, 2017
Phase: N/A
Study type: Observational

Diabetic retinopathy (DR) is the most common visual complication of diabetes. Risk factors for developing DR are diabetes duration, glycemic control, and hypertension . The prevalence ranges from 17 to 61% according to the diabetes duration . Obstructive sleep apnea syndrome (OSAS) is very frequent in Type 2 Diabetes population, reaching a prevalence of 23-48% . Few is known about the exact role of OSAS in the development of DR. A recent study has shown that OSAS is an independent predictor for the progression to pre-/proliferative DR. The purpose of the present study is to assess if the presence of OSA in diabetic patients is a predictive factor for DR occurrence.

NCT ID: NCT03314441 Not yet recruiting - Primary Insomnia Clinical Trials

Effects of Yoga in Primary Insomnia

Start date: October 17, 2017
Phase: N/A
Study type: Interventional

The purpose of the study is to assess the effects of regular Viniyoga in patients suffering from primary insomnia.

NCT ID: NCT03314363 Enrolling by invitation - Acute Renal Failure Clinical Trials

Plasma CO2 Removal Due to CRRT and Its Influence on Indirect Calorimetry

MECCIAS
Start date: April 26, 2017
Phase: N/A
Study type: Interventional

The aim of the present study is to assess the metabolic impact of Continuous Renal Replacement Therapy and overview the obstacles and important factors compromising the use of Indirect Calorimetry in CRRT and suggest a model to overcome these issues.

NCT ID: NCT03312725 Recruiting - Clinical trials for Ruptured and Unruptured Intracranial Aneurysms

Mid-term Data Collection of the Treatment of Intracranial Aneurysms With the WEBâ„¢ Aneurysm Embolization System

Start date: February 1, 2017
Phase: N/A
Study type: Observational [Patient Registry]

Flow disruption is a new endovascular approach for treatment of both ruptured and unruptured intracranial aneurysms, which involves placement of an endosaccular device (WEB) which modifies the blood flow at the level of the neck and induces intraaneurysmal thrombosis. The WEB was designed to treat wide-neck bifurcation aneurysms. This observational study will collect data about the routine practice in one center of using the WEB in ruptured and unruptured intracranial aneurysms. The primary objective is to evaluate its efficacy by assessing the anatomic outcome during follow-up.

NCT ID: NCT03312465 Recruiting - Clinical trials for Rheumatoid Arthritis

Anatomical Shoulder Domelock System Study

Start date: September 28, 2017
Phase: N/A
Study type: Observational

The objectives of this study are to confirm safety and performance of the Anatomical Shoulder Domelock System when used in hemi or total shoulder arthroplasty by analysis of standard scoring systems, radiographs and adverse event records.

NCT ID: NCT03310008 Recruiting - Clinical trials for Colon Cancer Liver Metastasis

Dose Escalation and Dose Expansion Phase I Study to Assess the Safety and Clinical Activity of Multiple Doses of NKR-2 Administered Concurrently With FOLFOX in Colorectal Cancer With Potentially Resectable Liver Metastases

SHRINK
Start date: August 7, 2017
Phase: Phase 1
Study type: Interventional

SHRINK (Standard cHemotherapy Regimen and Immunotherapy with NKR-2) is an open-label Phase I study to assess the safety and clinical activity of multiple administrations of autologous NKR-2 cells administered concurrently with a standard chemotherapy treatment (FOLFOX) in potentially resectable liver metastases from colorectal cancer. The trial will test three dose levels. At each dose, the patients will receive three successive administrations, two weeks apart, NKR-2 cells. The study will enroll up to 36 patients (dose escalation and expansion phases).

NCT ID: NCT03309605 Recruiting - Genetic Disease Clinical Trials

Phase 1 Study of ELX-02 in Healthy Adult Subjects

Start date: October 11, 2017
Phase: Phase 1
Study type: Interventional

Phase 1 Multiple Ascending Dose Study in Normal Healthy Volunteers