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NCT ID: NCT00379431 Completed - Clinical trials for Early and Severe Systemic Sclerosis

A Protocol Based Treatment for Early and Severe Systemic Sclerosis With (Anti-CD20), Rituximab

Start date: November 27, 2006
Phase: Phase 2
Study type: Interventional

Rituximab 1000 mg i.v. will be given on day 1 and 15, week 26 - 28, together with a corticosteroid regimen consisting of methylprednisolone 100 mg i.v. 30 minutes prior to both infusions.

NCT ID: NCT00378690 Completed - Prostate Cancer Clinical Trials

A Phase IIIb Study of Intermittent Versus Continuous Hormone Deprivation Treatment With ELIGARD

ICELAND
Start date: March 2006
Phase: Phase 3
Study type: Interventional

Phase IIIb, Open-label, randomized, controlled multi-centre study. Induction therapy phase for 6 months where all subjects receive 2 ELIGARD depot injections. Those subjects with hormone responsive prostate cancer will be randomized and will receive either intermittent or continuous ELIGARD treatment for 36 months. Following this treatment period, subjects will enter a long-term follow-up period for 48 months.

NCT ID: NCT00378144 Completed - Headache Clinical Trials

Efficacy and Safety of Sinutab on Subjects in the Setting of a Common Cold

Start date: January 2007
Phase: Phase 4
Study type: Interventional

The purpose of this study is to investigate the efficacy and safety for a marketed sinus allergy product, Sinutab, in the treatment of nasal congestion and headache.

NCT ID: NCT00377793 Completed - Sexual Dysfunction Clinical Trials

Levitra (Vardenafil, BAY38-9456) Partner Satisfaction Study II

Start date: July 2006
Phase: Phase 4
Study type: Interventional

This trial is to provide additional important information on the impact of the treatment of the man its ED with vardenafil on partnership. This study is being run at up to 50 study centers in Europe and South Africa to evaluate the use of vardenafil in adult men with erectile dysfunction (often called impotence), and their female partner's sexual quality of life. Many men experience occasional erectile problems during their lives. However, when this becomes a continued problem, it can affect both the man and his female partner. The causes of erectile dysfunction are varied and may be due to physiological or emotional reasons. This study is designed to 1) study the effectiveness and safety of vardenafil, and 2) show whether treating a man its erectile dysfunction with vardenafil will improve his female partner its sexual quality of life. The second part (week 12) of the study (Educational program) a subgroup of subjects/couples, approximately 50% of the randomized subjects, will receive an educational program concerning ED in the from of a DVD.

NCT ID: NCT00377637 Completed - Lupus Nephritis Clinical Trials

A Study of Mycophenolate Mofetil (CellCept) in Management of Patients With Lupus Nephritis.

Start date: July 2005
Phase: Phase 3
Study type: Interventional

This 2 arm study assessed the efficacy of Mycophenolate Mofetil (MMF; CellCept) compared to cyclophosphamide in inducing a response in patients with lupus nephritis, and the long term efficacy of MMF compared to azathioprine in maintaining remission and renal function. Patients were randomized to receive either MMF (1.5 g twice daily [bid]) or cyclophosphamide (0.5-1.0 g/m^2 in monthly pulses) in the induction phase. Those patients meeting criteria for response were re-randomized for entry into the maintenance phase, to receive either MMF (1 g bid) or azathioprine (2 mg/kg/day).

NCT ID: NCT00377585 Completed - Influenza Clinical Trials

Demonstrate the Superiority of the Immune Response of Adjuvanted Influenza Vaccine Induced in an Adult Population

Start date: September 22, 2006
Phase: Phase 2
Study type: Interventional

The study is designed to demonstrate a meaningful difference in immunogenicity between the candidate adjuvanted vaccine compared to the licensed Fluarix vaccine in subjects aged 50 years and above. A control group in younger adults aged 18 to 40 years was included.

NCT ID: NCT00377169 Completed - HIV Infections Clinical Trials

Collection of Blood Samples From SMART Study Participants for Future Genetic Studies

Start date: n/a
Phase: N/A
Study type: Observational

The purpose of this study is to collect blood samples from SMART study participants to use in future genetic studies.

NCT ID: NCT00376714 Completed - Clinical trials for Pulmonary Disease, Chronic Obstructive

Safety And Tolerability Study In Patients With Chronic Obstructive Pulmonary Disease

Start date: August 16, 2006
Phase: Phase 2
Study type: Interventional

GSK233705 is a high-affinity specific muscarinic receptor (mAChR) antagonist which is being developed for once daily treatment of chronic obstructive pulmonary disease (COPD). The long duration of action of GSK233705 when administered via inhalation in animal models supports the potential for use as a once-daily bronchodilator for chronic obstructive pulmonary disease.

NCT ID: NCT00374842 Completed - Influenza Clinical Trials

Study to Evaluate the Immunogenicity and Safety of 2 Formulations of GlaxoSmithKline (GSK) Biologicals' GSK1247446A Low Dose Influenza Vaccine Candidate

Start date: October 3, 2006
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the immunogenicity and the safety of candidate vaccines compared to Fluarix™ administered intramuscularly in subjects aged 18-59 years

NCT ID: NCT00374387 Completed - Healthy Clinical Trials

Psychosocial and Physiological Mechanisms in the Effect of Hormonal Contraception on the Female Sexual Desire

Start date: September 2006
Phase: N/A
Study type: Interventional

75 heterosexual women are asked to use 3 different types of contraception (Nuvaring, low-dose combination pill, minipill), each during 3 months. On a monthly basis, questionnaires are filled out about sexual desire and psychosocial, relational en sexual parameters. Also the sexual desire of the partner is questioned. On a three-monthly basis, blood samples are drawn to determine changes in hormonal parameters (one sample per product period). 75 lesbian women are doing the same trial, but during an extra 3 months period, they are asked to have their natural menstrual cyclus as a control condition. Blood samples during these extra months will be drawn at the third or fourth day after start of the menses.