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NCT ID: NCT00687804 Completed - Clinical trials for Diabetic Macular Edema

A 12 Month Core Study to Assess the Efficacy and Safety of Ranibizumab (Intravitreal Injections) in Patients With Visual Impairment Due to Diabetic Macular Edema and a 24 Month Open-label Extension Study

RESTORE
Start date: May 2008
Phase: Phase 3
Study type: Interventional

CRFB002D2301: The core study was designed to confirm the efficacy and safety of ranibizumab (0.5 mg) as adjunctive therapy when added to laser photocoagulation and/or mono-therapy in patients with visual impairment due to diabetic macular edema. CRFB002D2301E1: A 24 month open-label extension study for participants who completed the 12 month core study evaluated the long-term safety and efficacy of ranibizumab (0.5 mg) as symptomatic treatment for visual impairment due to diabetic macular edema.

NCT ID: NCT00686959 Completed - Clinical trials for Non Small Cell Lung Cancer

Chemotherapy and Radiation in Treating Participants With Stage 3 Non-Small Cell Lung Cancer

PROCLAIM
Start date: September 2008
Phase: Phase 3
Study type: Interventional

This study will compare the overall survival of participants with locally-advanced, Stage III Non-Small Cell Lung Cancer (NSCLC) with nonsquamous cell histology.

NCT ID: NCT00686868 Completed - Clinical trials for Arthritis, Rheumatoid

Study to Evaluate SC Route of Administration of Ofatumumab in RA Patients

Start date: June 13, 2008
Phase: Phase 1
Study type: Interventional

This study will examine the safety and tolerability, PK and PD of subcutaneously administered GSK1841157 in patients with RA on stable dose Methotrexate. The study comprises a single dose escalation/de-escalation phase to investigate the minimal efficacious dose based on PD markers with an acceptable safety profile.

NCT ID: NCT00685373 Completed - Clinical trials for Familial Cold Autoinflammatory Syndrome

Efficacy and Safety of ACZ885 in Patients With the Following Cryopyrin-associated Periodic Syndromes: Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, or Neonatal Onset Multisystem Inflammatory Disease

Start date: May 2008
Phase: Phase 3
Study type: Interventional

This will provided long-term safety and efficacy data for ACZ885 (a fully human anti-interleukin-1β [anti-IL-1β] monoclonal antibody) given as an injection subcutaneously in patients who participated in the CACZ885A2102 (NCT00487708), CACZ885D2201 (NCT00685373) or CACZ885D2304(NCT00465985) studies or newly identified patients with the following cryopyrin-associated periodic syndromes: Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome or Neonatal Onset Multisystem Inflammatory Disease. The duration of this study was 6 months with a maximum duration of 2 years

NCT ID: NCT00684671 Completed - Hepatitis B Clinical Trials

Evaluation of Immune Memory to Twinrix or Comparator by Challenge Dose Administration 4 Years After Primary Vaccination

Start date: May 26, 2008
Phase: Phase 4
Study type: Interventional

Only subjects who participated in the primary study will be invited to participate in the extension phase and the challenge dose phase of this study.

NCT ID: NCT00681850 Completed - Diabetes Clinical Trials

OPtimal Type 2 dIabetes Management Including Benchmarking and Standard trEatment.

Optimise
Start date: March 2008
Phase:
Study type: Observational

Demonstrate that the use of benchmarking improves quality of patient care, in particular the control of diabetes, lipids and blood pressure, by determining the percentage of patients in the benchmarking group achieving pre-set targets for HbA1c 14,18, LDL-cholesterol16,18 and Systolic Blood Pressure17,18 versus control group (non-benchmarking group) after 12 months of follow-up.

NCT ID: NCT00681122 Completed - Breast Cancer Clinical Trials

CARIATIDE (Compliance of ARomatase Inhibitors AssessmenT In Daily Practice Through Educational Approach)

CARIATIDE
Start date: May 2008
Phase: N/A
Study type: Observational

This observational study is restricted to postmenopausal women with hormone-sensitive early breast cancer, who have decided to take prescribed adjuvant use of AIs, anastrozole or letrozole, according to the current product SmPCs. There is no Investigational Medicinal Product (IMP) to be taken in this observational study. The adjuvant AI medication must not have exceeded thirteen weeks. In CARIATIDE (Compliance of ARomatase Inhibitors AssessmenT In Daily practicE through Educational approach), impact of educational material on women's compliance and persistence rates will be evaluated.

NCT ID: NCT00680927 Completed - Atrial Fibrillation Clinical Trials

Reveal® XT Performance Trial (XPECT)

Start date: September 2007
Phase: Phase 4
Study type: Interventional

The purpose of this study is to quantify the accuracy of the atrial fibrillation diagnostics of the Reveal® XT in a clinical setting and to verify overall system performance, R-wave sensing performance, to obtain user feedback, from both patient and physician, and collect data on device safety.

NCT ID: NCT00679731 Completed - Psoriasis Clinical Trials

A Study of Safety and Efficacy Comparing ABT-874 Versus Methotrexate in Subjects With Moderate to Severe Plaque Psoriasis

Start date: April 2008
Phase: Phase 3
Study type: Interventional

This study is being conducted to compare the efficacy of ABT-874 versus Methotrexate in subjects with moderate to severe plaque psoriasis.

NCT ID: NCT00679705 Completed - Healthy Clinical Trials

Influence of Tocolytical Medications on Hemodynamics (Central and Peripheral) and Vascular Function in a Pilot Study to Determine the Design of the Final Study and the Final Study Itself

Start date: May 2008
Phase: Phase 1
Study type: Interventional

This trial will consist of two parts: A pilot study in a three-way cross over trial to determine the highest well tolerated dose of Ritodrine (Pre-Par®), the impact of Atosiban (Tractocile®) on the hemodynamics and hence the design of the final study. The final study is planned as a three-way crossover trial to investigate and compare the cardiovascular effects of Ritodrine, Atosiban and placebo to relate those effects to the pharmacokinetics of Ritodrine and Atosiban (PK/PD modelling).