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NCT ID: NCT00384358 Completed - Fractures Clinical Trials

Feasibility And Safety Study Of rhBMP-2/CPM For Hip Fractures

Start date: December 2006
Phase: Phase 2
Study type: Interventional

The primary objective of this study is to assess the safety of administering rhBMP-2/CPM as an adjuvant to internal fixation in subjects with fractures of the proximal femur.

NCT ID: NCT00384176 Completed - Colorectal Cancer Clinical Trials

First Line Metastatic Colorectal Cancer Therapy in Combination With FOLFOX

HORIZON III
Start date: August 30, 2006
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of this study is to see if Cediranib in combination with FOLFOX is effective in treating metastatic colorectal cancer and to see how it compares with Avastin (Bevacizumab) in combination with FOLFOX.

NCT ID: NCT00384046 Completed - Clinical trials for Hypoactive Sexual Desire Disorder

Testosterone Therapy in Naturally Menopausal Women With Low Sexual Desire Receiving Transdermal Estrogen

Start date: November 2006
Phase: Phase 3
Study type: Interventional

The purpose of this study is to examine whether the transdermal testosterone system (TTS) is effective and safe in the treatment of hypoactive sexual desire disorder (HSDD) in postmenopausal women who are on transdermal estrogen.

NCT ID: NCT00383422 Completed - Clinical trials for Osteoporosis, Postmenopausal

Study Comparing Arzoxifene With Raloxifene in Women After Menopause With Osteoporosis

Start date: October 2006
Phase: Phase 3
Study type: Interventional

The purpose of this study is to compare the effect of arzoxifene to raloxifene on the bone mineral density (bone strength).

NCT ID: NCT00383292 Completed - Metastatic Melanoma Clinical Trials

A Study of Tasisulam in Treating Participants With Malignant Melanoma

Start date: November 2006
Phase: Phase 2
Study type: Interventional

The primary purpose of this study is to determine the objective response rate (complete and partial response) for participants who receive tasisulam after one prior systemic treatment for unresectable or metastatic melanoma.

NCT ID: NCT00383253 Completed - Obesity Clinical Trials

Methods Study to Characterize Early Indicators of Weight Loss in People

Start date: October 2006
Phase: N/A
Study type: Interventional

Methods study to characterize early indicators of weight loss in people.

NCT ID: NCT00383188 Completed - Clinical trials for Arthritis, Rheumatoid

An Oral p38 Inhibitor Investigating Safety, Efficacy, And PK In Subjects With Active Rheumatoid Arthritis

Start date: December 15, 2006
Phase: Phase 2
Study type: Interventional

Investigating the safety and tolerability of a p38 inhibitor as monotherapy in subjects who have failed at least 1 DMARD.

NCT ID: NCT00382811 Completed - Ovarian Cancer Clinical Trials

OVATURE (OVArian TUmor REsponse) A Phase III Study of Weekly Carboplatin With and Without Phenoxodiol in Patients With Platinum-Resistant, Recurrent Epithelial Ovarian Cancer

OVATURE
Start date: October 2006
Phase: Phase 3
Study type: Interventional

The purpose of this project is to see if weekly carboplatin compared with phenoxodiol in combination with weekly carboplatin, is effective against late stage ovarian cancer and to see what, if any, side-effects of treatment may result.

NCT ID: NCT00382226 Completed - Glaucoma Clinical Trials

IOP-Lowering Efficacy of Brinzolamide 1.0% Added to Travoprost 0.004%/Timolol 0.5% Fixed Combination as Adjunctive Therapy

Start date: September 2006
Phase: Phase 4
Study type: Interventional

Uncontrolled glaucoma patients being treated with a prostaglandin agent alone or in combination with adjunctive drugs in fixed or unfixed combinations, will be switched from their current therapy to travoprost/timolol fixed combination and either Azopt or placebo

NCT ID: NCT00382109 Completed - Clinical trials for Graft Versus Host Disease

Tacrolimus and Methotrexate With or Without Sirolimus in Preventing Graft-Versus-Host Disease in Young Patients Undergoing Donor Stem Cell Transplant for Acute Lymphoblastic Leukemia in Complete Remission

Start date: March 2007
Phase: Phase 3
Study type: Interventional

This randomized phase III trial is studying tacrolimus, methotrexate, and sirolimus to see how well they work compared to tacrolimus and methotrexate in preventing graft-versus-host disease in young patients who are undergoing donor stem cell transplant for intermediate-risk or high-risk acute lymphoblastic leukemia in second complete remission and high risk acute lymphoblastic leukemia in first remission. Giving chemotherapy, such as thiotepa and cyclophosphamide, and total-body irradiation before a donor stem cell transplant helps stop the growth of cancer cells. It also helps stop the patient's immune system from rejecting the donor's stem cells. The donated stem cells may replace the patient's immune cells and help destroy any remaining cancer cells (graft-versus-tumor effect). Sometimes the transplanted cells from a donor can also make an immune response against the body's normal cells. Giving tacrolimus, methotrexate, and sirolimus after the transplant may stop this from happening. It is not yet known whether tacrolimus and methotrexate are more effective with or without sirolimus in preventing graft-versus-host disease.