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Glaucoma clinical trials

View clinical trials related to Glaucoma.

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NCT ID: NCT06313749 Not yet recruiting - Open Angle Glaucoma Clinical Trials

Safety and Effectiveness of Minimally Invasive Micro Sclerostomy (MIMS®) to Reduce Intraocular Pressure in Open-Angle Glaucoma Which is Not Controlled Despite Polypharmacy

Start date: April 2024
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to show non-inferiority of the MIMS® device/procedure with Mitomycin-C, in terms of its surgical success rate, compared to trabeculectomy with Mitomycin-C in subjects diagnosed with primary open angle glaucoma, whose intraocular pressure is not controlled despite polypharmacy. Eligible screened participants will undergo the MIMS® procedure and will be followed for a period of 12 months in this single-arm study. Investigators will compare the results of this study to the surgical success rate of traditional trabeculectomy with Mitomycin-C.

NCT ID: NCT06305481 Recruiting - Glaucoma Clinical Trials

Glaucoma Evaluation With the P200TE

Start date: February 13, 2024
Phase: N/A
Study type: Interventional

Images captured on the P200TE device on glaucoma patients

NCT ID: NCT06294015 Not yet recruiting - Glaucoma Clinical Trials

Efficacy of 20% Autologous Serum Drops in the Treatment of Corneal Epitheliopathy Associated With Antihypertensive Glaucoma Drops.

Start date: March 2024
Phase: Phase 4
Study type: Interventional

Introduction: Glaucoma is the second leading cause of blindness globally. Most anti-hypertensive drops contain preservatives harmful to the corneal epithelium, with up to 78% of treated patients reporting dry eye symptoms. Autologous serum eye drops (ASED), contains essential growth factors and nutrients which may promote corneal and conjunctival integrity, offering benefits over traditional treatments. This study investigates the efficacy of 20% ASED over placebo in the treatment of corneal epitheliopathies in patients with glaucoma treated with antihypertensive drops. Methods: The present study is a triple-blinded, randomized controlled trial that anticipates to enroll 25 patients (50 eyes) with bilateral corneal epitheliopathy secondary to antihypertensive glaucoma treatments. Patients will receive autologous serum eye drops in one eye and placebo in the contralateral eye for two months, in addition to standard artificial tears treatment. The primary outcome is the comparison of National Eye Institute (NEI) scores between autologous serum drops and placebo-treated eyes at two months. Secondary outcomes include Schirmer's test scores, visual acuity, tear break-up time (TBUT), Ocular Surface Disease Index (OSDI) scores, intraocular pressure, and complication rates. The study aims to analyze the effectiveness of autologous serum eye drops in treating corneal epitheliopathies in glaucoma patients, potentially offering a new therapeutic avenue.

NCT ID: NCT06289491 Not yet recruiting - Glaucoma Clinical Trials

Randomized Trial of Hydrus Microstent Versus Goniotomy

Start date: April 2024
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to evaluate the comparative efficacy and safety of Hydrus Microstent, incisional goniotomy, and excisional goniotomy when combined with cataract surgery in patients with mild and moderate open-angle glaucoma. The main questions it aims to answer are: - How do the intraocular pressure lowering effects of these three microinvasive glaucoma surgeries compare? - How do the safety profiles of these three microinvasive glaucoma surgeries compare? Participants will be randomized to one of these three microinvasive glaucoma surgeries in combination with cataract surgery.

NCT ID: NCT06278597 Recruiting - Glaucoma Clinical Trials

Automatic Evaluation of the Anterior Chamber Angle Width by a New Non-contact Optical Device

Start date: September 5, 2023
Phase: N/A
Study type: Interventional

The aim of the study is to evaluate an objective, non-invasive optical device able to quantify, without eye contact, the width of the irido-corneal angle and to better identify cases of narrow angle or angle closure that may be prevented with relatively simple treatments.

NCT ID: NCT06274593 Not yet recruiting - Glaucoma Clinical Trials

Study of OCT Peripapillary Angiography in Patients With Advanced Glaucoma

OGA
Start date: April 2024
Phase:
Study type: Observational

Glaucoma is a chronic disease of the optic nerve, characterized by progressive loss of nerve cells in the retina, leading to progressive loss of peripheral and central vision. There are in fact several types of glaucoma, which is the world's second leading cause of blindness after cataracts, and the leading cause of irreversible blindness. To date, to our knowledge, there is no work analyzing the progression of angiographic OCT in patients with glaucoma. The main aim of this study is to compare the 3-year progression rate of 3 examinations in advanced glaucoma patients: one functional (visual field) and two anatomical (OCTa and OCTrnfl).

NCT ID: NCT06267274 Not yet recruiting - Ocular Hypertension Clinical Trials

A Randomized, Double-blind, Parallel-group, Two-arm, Multiple Dose, Multicenter, Bioequivalence Study With Clinical Endpoint in the Treatment of Subjects With Chronic Open-angle Glaucoma or Ocular Hypertension in Both Eyes

Start date: March 1, 2024
Phase: Phase 1
Study type: Interventional

A randomized, double-blind, parallel-group, two-arm, multiple dose, multicenter, clinical endpoint bioequivalence study

NCT ID: NCT06266351 Not yet recruiting - Glaucoma Clinical Trials

EVALUATION OF CATS TONOMETER PRISM IN LASIK SUBJECTS

Start date: February 12, 2024
Phase:
Study type: Observational

The CATS Tonometer prism clinical study is intended to determine repeatability of intraocular pressure measurement in human corneas which have undergone a LASIK procedure when compared to a standard Goldmann prism, validating the human LASIK eye findings comparing CATS Tonometer and Goldmann prisms to intracameral pressure in cadaver eyes.

NCT ID: NCT06252246 Completed - Clinical trials for Primary Angle Closure Glaucoma

The Effect of Phacoemulsification on Intraocular Pressure in Primary Angle Closure Glaucoma (PACG) Patients At Phanat Nikhom Hospital, Chonburi Province

Start date: October 1, 2017
Phase:
Study type: Observational

BACKGROUND: Primary angle closure glaucoma (PACG) is one of a leading cause of blindness worldwide including Thailand. This problem impact to the overall health of people and health care system. Treatment guidelines of each stage is differenced. Therefore, factors that affect to treatment should be explored to plan for taking care patients in the future. OBJECTIVES: The study aimed to examine the effects of cataract surgery by phaco- emulsification on intraocular pressure and to determine the factors associated with intraocular pressure among primary angle closure glaucoma patients.

NCT ID: NCT06249152 Not yet recruiting - Glaucoma Clinical Trials

Qlaris Study of QLS-111 in Combination With a PGA for OAG and/or OHT Patients

Start date: April 15, 2024
Phase: Phase 2
Study type: Interventional

Qlaris Phase 2 clinical study investigating the safety, tolerability, and ocular hypotensive efficacy of QLS-111 in combination with latanoprost in open-angle glaucoma (OAG) and/or ocular hypertension (OHT) patients.