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NCT ID: NCT00046228 Completed - Clinical trials for Myocardial Infarction

A Study of Abciximab and Reteplase When Administered Prior to Catherization After a Myocardial Infarction (Finesse)

Start date: August 2002
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine whether abciximab given in combination with reteplase, before patients have a coronary intervention (a standard treatment where a catheter is inserted into the heart artery to get blood flowing past the clot), is safe and effective in the treatment of heart attacks compared to only abciximab given during coronary intervention.

NCT ID: NCT00045760 Completed - Sepsis Clinical Trials

The Study of Drotrecogin Alfa (Activated) in a Subpopulation of Adult Patients With Severe Sepsis

Start date: September 2002
Phase: Phase 4
Study type: Interventional

Severe sepsis is defined as a systemic inflammatory response syndrome that results from infection and is associated with acute organ dysfunction. It usually results from bacterial infections, but it may occur in response to other pathogens, such as fungi, viruses, and parasites.

NCT ID: NCT00044915 Completed - Stroke Clinical Trials

Repinotan in Patients With Acute Ischemic Stroke

Start date: December 2000
Phase: Phase 2
Study type: Interventional

The purpose of this trial is to evaluate Repinotan HCl in patients with acute ischemic stroke. At study entry patients will be randomized to Repinotan HCl or placebo in a 1:1 ratio. The total treatment period wil be 72 hours.

NCT ID: NCT00044070 Completed - Clinical trials for Cerebrovascular Accident

A Study to Evaluate the Effects of YM872 on Stroke Lesion Volume in Acute Stroke Patients

Start date: December 2000
Phase: Phase 2
Study type: Interventional

This study will investigate the effects of a potential neuroprotectant compound, YM872, in the treatment of acute ischemic stroke. The study will determine if a 24-hour infusion of YM872, given within 6 hours of stroke onset, reduces the ischemic lesion volume as measured by MRI at 28 days after the infusion is given. The clinical effects of YM872 will also be determined by neurological function and disability scores at follow up visits through Day 90 of the study.

NCT ID: NCT00044057 Completed - Clinical trials for Acute Ischemic Stroke

A Study to Evaluate the Effects of YM872 on Brain Function and Disability When Administered in Combination With Alteplase (Tissue Plasminogen Activator)

Start date: December 2000
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine if YM872 in combination with t-PA can reduce disability and brain damage from stroke. YM872 or placebo will be given as a continuous intravenous (iv) infusion for 24 hours. It is important that the study medication, YM872 or placebo, is administered prior to the completion of the t-PA administration. The clinical effects of YM872 in addition to t-PA will be determined by assessing neurological function and disability scores at follow up visits through Day 90 of the study.

NCT ID: NCT00043927 Completed - Clinical trials for Small Cell Lung Cancer

Extensive Small Cell Lung Cancer Treatment Using An Investigational Drug Plus Chemotherapy In Chemotherapy-Naive Adults

Start date: April 2001
Phase: Phase 3
Study type: Interventional

This study will gather and compare data about the effectiveness and safety of two different treatments for extensive Small Cell Lung Cancer (SCLC) in patients who have not received previous chemotherapy. One treatment will use an investigational drug in combination with an FDA approved chemotherapy. The other treatment will use a combination of two FDA approved chemotherapy drugs.

NCT ID: NCT00039364 Completed - Clinical trials for Brain and Central Nervous System Tumors

Imatinib Mesylate in Treating Patients With Gliomas

Start date: March 2002
Phase: Phase 2
Study type: Interventional

RATIONALE: Imatinib mesylate may interfere with the growth of tumor cells and slow the growth of the tumor. PURPOSE: Phase II trial to study the effectiveness of imatinib mesylate in treating patients who have gliomas.

NCT ID: NCT00036556 Completed - Prostatic Neoplasms Clinical Trials

Study of Atrasentan in Men With Non-Metastatic, Hormone-Refractory Prostate Cancer

Start date: June 2001
Phase: Phase 3
Study type: Interventional

This study is being done to evaluate the safety and efficacy of atrasentan in men with non-metastatic hormone-refractory prostate cancer.

NCT ID: NCT00036543 Completed - Prostate Cancer Clinical Trials

A Study of Atrasentan in Men With Metastatic, Hormone-Refractory Prostate Cancer

Start date: May 2001
Phase: Phase 3
Study type: Interventional

This study is being done to evaluate the safety and efficacy of atrasentan in men with metastatic hormone-refractory prostate cancer.

NCT ID: NCT00036179 Completed - Candidiasis Clinical Trials

Study of FK463 in the Treatment of Candidemia or Invasive Candidiasis

Start date: February 27, 1999
Phase: Phase 2
Study type: Interventional

The purpose of the study is to evaluate the safety and efficacy of FK463 in the treatment of patients with confirmed candidemia or invasive candidiasis.