Coronary Artery Disease Clinical Trial
Official title:
Effect of Exercise Training on Left Ventricular Function in Patients Post Myocardial Infarction: The EXercise Interval Training - V Study
Patients who have suffered a heart attack are at risk of developing worsening heart function and heart failure. Exercise training has a beneficial effect on heart function and prevents heart failure. The aim of the current study is to investigate the effect of exercise training on heart function in patients who have suffered a heart attack.
Patients who have suffered a myocardial infarction are at significant risk for developing
heart failure and progressive left ventricular dysfunction One of the proposed mechanisms
responsible for this observation is reduction in myocardial beta-adrenergic receptor density
due to elevated cell membrane protein G - protein coupled receptor kinase -2 (GRK2).
It is known that exercise training preserves heart function in patients who have suffered a
myocardial infarction. The mechanism for this is not clear.
The purpose of this study is to examine the effect of exercise training on myocardial
function and GRK2 levels in patients who have suffered a myocardial infarction, with the
hypothesis that exercise training in this population reduces GRK2 levels and preserves or
improves myocardial function.
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