Cardiovascular Diseases Clinical Trial
To determine the factors associated with progression of sub-clinical atherosclerosis and to evaluate the associations between the progression of sub-clinical atherosclerosis and the development of clinically manifest atherosclerosis.
BACKGROUND:
Cardiovascular disease remains the leading cause of death in the United States and one of
the leading causes of morbidity. New technology recently has allowed the non-invasive
investigation of the extent of atherosclerosis in different vascular beds. Unfortunately,
the clinical implications and significance of this new technology have not yet been fully
examined nor has the interrelationship between these various measurements of clinical and
sub-clinical atherosclerosis. The study is ancillary to the Multi-Ethnic Study of
Atherosclerosis (MESA), an NHLBI-supported epidemiological study of atherosclerosis in
several ethnic groups.
DESIGN NARRATIVE:
A longitudinal assessment of the carotid intima media thickness (IMT) will be added to the
scheduled follow-up visits in MESA subjects in order to study the relationship between
carotid IMT and a measure of calcium burden in the coronary vessels. In addition, studies
will be conducted on how these two non-invasive markers of atherosclerosis relate to
cardiovascular disease risk factors and clinical events.The study will utilize the MESA
cohort involving 6500 subjects who will have baseline and four follow-up examinations.
coronary artery calcification (CAC) and IMT are being obtained at baseline, with CAC
determinations also scheduled at follow-up. IMT determinations will be added in conjunction
with the CAC studies in the second and third exams and detailed analyses will be carried out
on these two measures of atherosclerotic burden that may reflect different biologic
processes.
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