Cardiovascular Diseases Clinical Trial
To determine the association between flavonoids intake and the prevention of incident cardiovascular disease (CVD).
BACKGROUND:
Basic science, clinical observation, and epidemiologic studies have all contributed to an
emerging body of evidence on the potential role of flavonoids, a group of polyphenolic
compounds with antioxidant properties, in the prevention of cardiovascular disease. However,
the few existing studies on flavonoids or its food sources have provided inconsistent
results, usually focusing on the primary prevention of coronary heart disease mortality. The
study used the small grant mechanism (R03) to analyze previously collected data.
DESIGN NARRATIVE:
The investigators examined whether flavonoid intake was associated with the risk of incident
CVD, and whether specific food sources of flavonoids--including tea, onions, apples, red
wine, and other foods--were associated with the risk of incident CVD. The investigators
processed and analyzed previously collected data of 39,876 middle-aged and older women free
of CVD; the Women's Antioxidant Cardiovascular Study (WACS), a prospective study of 8,171
middle-aged and older women with pre-existing CVD or more than three coronary risk factors;
the Normative Aging Study (NAS), a prospective study of 2,280 middle-aged and older men; and
the Boston Area Health Study (BAHS), a case-control study of first nonfatal myocardial
infarction in men and women aged less than 76 years. Using data from semiquantitative food
frequency questionnaires administered in each study, the investigators determined individual
intake of flavonoids and its food sources. Unlike previous studies, they examined flavonoids
in relation to both the primary and secondary prevention of incident cardiovascular disease
(CVD), consisting of confirmed cases of nonfatal myocardial infarction (Ml), nonfatal
stroke, revascularization procedures, and CVD death.
The study completion date listed in this record was obtained from the "End Date" entered in
the Protocol Registration and Results System (PRS) record.
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