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Cancer clinical trials

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NCT ID: NCT03352934 Not yet recruiting - Cancer Clinical Trials

Avelumab Treatment in Patients With Neuroendocrine Carcinomas (NEC G3) Progressive After Chemotherapy

AveNEC
Start date: November 2017
Phase: Phase 2
Study type: Interventional

The purpose of the AveNEC trial is to investigate the clinical activity and safety of avelumab in patients with NEC G3 (WHO 2010), including "NET G3" who are progressive after first line chemotherapy.

NCT ID: NCT03351231 Recruiting - Cancer Clinical Trials

An Investigational Immuno-Therapy Study of Experimental Medication BMS-986242 Given in Combination With Nivolumab in Patients With Advanced Cancer

Start date: November 27, 2017
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to investigate safety of experimental medication BMS-986242 and Nivolumab in patients with advanced cancers.

NCT ID: NCT03351140 Not yet recruiting - Cancer Clinical Trials

Patient‐Reported Outcome Measurement Information System (PROMIS) Physical Function

Start date: December 8, 2017
Phase: N/A
Study type: Observational

The objective of this study is to conduct in-person qualitative interviews of subjects who have different tumor types to identify and assess relevant PROMIS physical function items that can be utilized in future studies. Health Research Associates (HRA) will conduct qualitative interviews in subjects with a variety of cancer types. PROMIS is a set of self‐report measurement tools, developed by the United States (US) National Institutes for Health (NIH). The most recent version of PROMIS Physical Function Item Bank contains 165 items assessing a range of abilities and its subset, a 45-item PROMIS Function Cancer Item Bank which contains questions relevant to subjects with cancer. Approximately 150 subjects with five tumor types will be recruited. HRA will conduct the interviews that will be audio-recorded for transcription and analysis. Five tumor types that will be focused on are Breast, Prostate, Non‐Small‐Cell Lung Cancer (NSCLC), Multiple Myeloma, and Diffuse Large B‐Cell (DLBCL) or Follicular Lymphoma. Interviews will be conducted in English language in private areas within clinic site or rented meeting facilities and will last approximately for 60-90 minutes.

NCT ID: NCT03350802 Recruiting - Cancer Clinical Trials

Procalcitonin Test for Differentiation of the Cause of Pneumonia

Start date: January 1, 2014
Phase: N/A
Study type: Observational

The purpose of this study is to evaluate the usefulness of procalcitonin test for differentiation of the cause of pneumonia in patients with cancer.

NCT ID: NCT03348826 Not yet recruiting - Cancer Clinical Trials

Study of Sodium Bicarbonate in Restoring Blocked Catheters

Start date: December 1, 2017
Phase: Phase 2
Study type: Interventional

This is a study looking at the use of sodium bicarbonate to restore the flow of blocked central line devices in patients with blood cancers. Central line devices uses thin tubes that are placed into a vein in the body to give medicines, fluids, nutrients, blood products, etc. Sometimes, the lines become blocked. The standard procedure to get the line working again is to use alteplase, a protein that dissolves blood clots. While blood clotting is one cause of a blocked line, other reasons included the formation of calcium deposits. Sodium bicarbonate is routinely used in the treatment of patients receiving chemotherapy. Sodium bicarbonate is a liquid drug which is capable of dissolving protein and calcium deposits. This study will compare whether sodium bicarbonate works just as well as alteplase to recover the function of a blocked line.

NCT ID: NCT03347162 Not yet recruiting - Cancer Clinical Trials

Muscle Dysfunction in Gastrointestinal or Hepatobiliary Cancer

Start date: November 1, 2018
Phase: N/A
Study type: Observational

PURPOSE: To determine the prognostic properties of a comprehensive evaluation of body composition and physical function in patients with GI-HEP cancer from point of diagnosis and throughout the treatment trajectory. GI-HEP: Patients with tumors of the upper gastrointestinal or hepatobiliary tract, specifically tumors of the esophagus, gastro-esophageal junction, stomach, primary tumors of the liver or biliary tract, as well as colorectal liver metastasis or tumors of the pancreas.

NCT ID: NCT03347058 Not yet recruiting - Cancer Clinical Trials

Immunotherapy & Me

Start date: December 4, 2017
Phase: N/A
Study type: Interventional

As usage and indications for immunotherapy (IO) increase, there presents a critical need to identify patient-centered and practice solutions across the continuum of care. Immunotherapy & Me is an innovative program of customizable resources that seeks to improve the patient experience by supporting the unique needs of both IO patients and the clinical staff who care for them. Cancer Support Community (CSC) will implement this operational framework of patient and provider tools at nine geographically and demographically diverse oncology practices. At the end of year one, CSC will evaluate program impact, retool interventions as necessary, and pursue additional funding with the goal extending services at existing practice sites - and scaling this turnkey model of IO treatment support.

NCT ID: NCT03343210 Not yet recruiting - Cancer Clinical Trials

Quality of Life and Cancers in Nursing Homes

QUALICE
Start date: December 1, 2017
Phase: N/A
Study type: Interventional

Quality of life (QOL) of nursing homes residents with cancer in France is not known. High prevalence of neurodegenerative diseases makes it difficult. It was found that oncological management is suboptimal among Poitevin territory residents. Publications report an inadequate management of symptoms of discomfort related to cancers. The multicentric study will comparate quality of life in patients with and without Cancers in nursing homes, including residents with neurodegenerative disease, using validated questionnaires. These questionnaires, as well as pain evaluation, will be carried out by a geriatric consultations' nurse.

NCT ID: NCT03341364 Recruiting - Cancer Clinical Trials

Pilot Study of an Acceptance and Commitment Based Group Therapy for Cancer Patients

Start date: September 16, 2017
Phase: N/A
Study type: Interventional

This study evaluates the preliminary effects of an Acceptance and Commitment (ACT)-based group therapy compared to individual ACT-therapy for adult cancer patients suffering from psychological distress. Half of the participants will receive ACT in a group setting, while the other half will receive individual ACT.

NCT ID: NCT03341286 Not yet recruiting - Cancer Clinical Trials

The Effect of an Oral Supplement,TK3 (Tryptophan and Thiamine) on the Quality of Life and Chemotherapy Tolerance in Cancer Patients With Advanced Disease.

TK3bFIIABC
Start date: November 2017
Phase: Phase 2
Study type: Interventional

The product under investigation relates to a pharmaceutical composition containing a pyrimidine nitrogen base, thymine, and the essential amino acid tryptophan. This product seems to have effect on quality of life and enhance adverse affects of chemotherapy in cancer patients.