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NCT ID: NCT05777109 Recruiting - Healthy Clinical Trials

Comparing of the PK, PD, Safety and Immunogenicity of HS-20090 and Xgeva® in Healthy Adults

Start date: April 20, 2023
Phase: Phase 1
Study type: Interventional

A Dual-center , Randomized, double-blinded and Parallel-controlled Study to Assess the Pharmacokinetic, pharmacodynamics, Safety and Immunogenicity of HS-20090 Injection and Xgeva® in Healthy Adults

NCT ID: NCT05779995 Recruiting - RSV Infection Clinical Trials

A Study To Evaluate the Safety of XW001 Inhalation in Children With RSV

Start date: April 20, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

This is a randomized, double-blind, placebo-controlled Phase Ib/IIa study to evaluate the safety, tolerability, efficacy, pharmacokinetics, and immunogenicity of XW001 inhalation in children with RSV infection in China

NCT ID: NCT05785039 Recruiting - Solid Tumor Clinical Trials

A Study of BL-B01D1 in Patients With Multiple Solid Tumors, Including Locally Advanced or Metastatic Urinary System Tumors

Start date: April 20, 2023
Phase: Phase 2
Study type: Interventional

Phase IIa/IIb clinical study to evaluate the safety, tolerability, pharmacokinetics and efficacy of BL-B01D1 for injection in patients with multiple solid tumors such as locally advanced or metastatic urinary system tumors.

NCT ID: NCT05795959 Recruiting - Lung Cancer Clinical Trials

Ensuring Precision-Medicine Delivery for Veterans With Lung Cancer

Start date: April 20, 2023
Phase: N/A
Study type: Interventional

The goal of this study is to learn if using a lay VA volunteer, who will assist patients with education regarding precision medicine, can improve care quality and outcomes for Veteran patients with lung cancer.

NCT ID: NCT05804227 Recruiting - Gliomas Clinical Trials

Window-of-Opportunity Trial of Ulixertinib for MAPK-Activated Low-Grade Gliomas in Adults

Start date: April 20, 2023
Phase: Early Phase 1
Study type: Interventional

To learn if the study drug, ulixertinib, can cross over the blood-brain barrier in patients with recurrent brain tumors

NCT ID: NCT05805137 Recruiting - Venous Ulcer Clinical Trials

Monitoring of Venous Ulcers Using a Bioimpedance Measurement Based Method and System

WoundWatchâ„¢
Start date: April 20, 2023
Phase: N/A
Study type: Interventional

The purpose of this study is to investigate the functionality of a new type of wound monitoring method and measurement system for monitoring healing of venous ulcers. The system is consisted of a wound dressing with electrodes (eDressing), a bioimpedance measurement device and a mobile phone application.

NCT ID: NCT05805813 Recruiting - Clinical trials for Chronic Kidney Disease 5D

Cross-control Study on the Effect of Peritoneal Rest on Peritoneal Transport Function in Peritoneal Dialysis Patients

CSEPR
Start date: April 20, 2023
Phase: N/A
Study type: Interventional

The investigators will carry out a prospective cross-over, pre-and post-controlled clinical study : 36 patients with continuous ambulatory peritoneal dialysis with high/high average transport will be recruited and treated with continuous ambulatory peritoneal dialysis and intermittent peritoneal dialysis at night (using automatic peritoneal dialysis machine) for 1 month respectively. The changes of peritoneal transport function and ultrafiltration volume before and after the two dialysis methods will be compared.

NCT ID: NCT05807074 Recruiting - Breast Cancer Clinical Trials

Impact of Topical Tranexamic Acid in Breast Reconstruction

Start date: April 20, 2023
Phase: Phase 4
Study type: Interventional

Improvement in bleeding and bruising has been described by using both intravenous and topical off-label applications of Tranexamic Acid (TXA) in many surgical fields. This trial tests how well applying tranexamic acid (TXA) to the surface of the surgical site (topically) works to reduce post-operative bleeding (hematomas) and fluid collections (seromas) in women undergoing surgery to remove both breasts (bilateral mastectomy) immediately followed by surgery to rebuild the breast (reconstruction). The formation of hematomas and seromas, a common post-mastectomy complication, can interfere with breast reconstruction and increase the risk of infection and wound healing and can potentially delay cancer treatments. TXA is a synthetic molecule that pushes the body's clotting cascade toward clot formation to improve blood clotting. Applying TXA topically to the surgical site before closing the incision may prevent hematoma and seroma formation in post-mastectomy breast reconstruction patients. Participants will be recruited from patients undergoing bilateral mastectomy at University of California, San Francisco.

NCT ID: NCT05817110 Recruiting - Lung Malignancy Clinical Trials

Validating Artificial Intelligence Effectiveness Defined Lung Nodule Malignancy Score in Patients With Pulmonary Nodule.

CREATE
Start date: April 20, 2023
Phase:
Study type: Observational

Artificial intelligence (AI) based algorithms have demonstrated increased accuracy in predicting the risk of Lung Cancer among patients with an incidental pulmonary nodule (IPN) on chest radiographs. Qure.ai, an AI company specializing in the reading of chest X- Rays (CXRs) by a proprietary algorithm and has developed a new model, qXR, that can report the lung nodule malignancy score (LNMS) based on lung nodule features. Our study aims to prospectively validate the lung nodule malignancy score against radiologist assessment of CT scans and Lung CT Screening Reporting and Data System score (Lung-RADS).(lung RADS score explained below) Thus, lung nodule malignancy score (interpreted by qXR as a high or low category) will be compared with radiologist-based assessment probability of CT scan and Lung-RADS assessment. The results of this prospective observational study will pave the way for improved nodule management, leading to better clinical outcomes in patients with incidental pulmonary nodule (IPNs), especially concerning malignancy assessment.

NCT ID: NCT05822011 Recruiting - Post Operative Pain Clinical Trials

Ultrasound Guided Rhomboid Intercostal Subserratus Plane Block vs Erector Spinae Plane Block in Open Nephrectomy

Start date: April 20, 2023
Phase: N/A
Study type: Interventional

Our aim is to measure the efficacy of rhomboid intercostal subserratus plane block and erector spinae plane block in comparison to thoracic epidural block in patients undergoing open nephrectomy