Paclitaxel and Bortezomib in Treating Patients With Metastatic or Unresectable Malignant Solid Tumors

Breast Cancer Clinical Trial

Official title:

Phase I Study of Paclitaxel (Taxol) and Bortezomib (Velcade) in Patients With Refractory Solid Tumor Malignancies Involving an Activated MAPK Pathway

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00667641
• Other study ID #: CDR0000592905
• Secondary ID: P30CA072720CINJ-
• Status: Completed
• Phase: Phase 1
• First received: April 25, 2008
• Last updated: May 9, 2011
• Start date: March 2007
• Est. completion date: February 2009

Study information

• Verified date: May 2011
• Source: Rutgers, The State University of New Jersey
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Food and Drug Administration
• Study type: Interventional

Clinical Trial Summary

RATIONALE: Drugs used in chemotherapy, such as paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Bortezomib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving paclitaxel together with bortezomib may kill more tumor cells.

PURPOSE: This phase I trial is studying the side effects and best dose of paclitaxel and bortezomib in treating patients with metastatic or unresectable malignant solid tumors.

Description:

OBJECTIVES:

Primary

• To identify the maximum tolerated dose of paclitaxel in combination with bortezomib in patients with metastatic or unresectable solid tumor malignancies that involve an activated Ras/Raf/MAPK pathway.

Secondary

• To assess the toxicity of this regimen.

• To assess tumor response in these patients.

• To determine whether Bim is upregulated in peripheral blood mononuclear cells obtained from patients treated with this regimen.

• To correlate markers of Ras/Raf/MAPK pathway activation in fresh or archived tumor tissue with clinical response in these patients.

• To perform pharmacokinetic (PK) studies to determine whether bortezomib alters paclitaxel PK parameters.

OUTLINE: Patients receive paclitaxel IV over 1 hour and bortezomib IV on days 1, 8, and 15. Treatment repeats every 21 days in the absence of disease progression or unacceptable toxicity.

Blood samples are collected at baseline and periodically during course 1 for pharmacokinetic and biomarker studies. Blood samples are analyzed for plasma concentrations of paclitaxel by high performance liquid chromatography and for Bim protein levels and phosphorylation status by western blotting. Tumor tissue samples, if available, are analyzed to evaluate the presence of an activated Ras/Raf/MAPK pathway. Tumor tissue samples are analyzed for Ras and/or Raf mutations by nucleic acid extraction and direct sequencing; Ras and/or Raf overexpression by western blotting; Ras activation assay; and/or phospho-ERK by western blotting and IHC.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 16
• Est. completion date: February 2009
• Est. primary completion date: February 2009
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

DISEASE CHARACTERISTICS:

• Histologically confirmed malignant solid tumor that involves an activated Ras/Raf/MAPK pathway, including the following:

• Breast cancer

• Prostate cancer

• Colon cancer

• Pancreatic cancer

• Ovarian cancer

• Non-small cell lung cancer

• Melanoma

• Papillary thyroid cancer

• Metastatic or unresectable disease

• Standard curative or palliative measures do not exist or are no longer effective

• No newly diagnosed, untreated, or uncontrolled brain metastases

PATIENT CHARACTERISTICS:

• ECOG performance status 0-2

• ANC = 1,500/µL

• WBC = 3,500/µL

• Platelet count = 100,000/µL

• Total bilirubin = 1.5 times upper limit of normal (ULN)

• AST/ALT = 2.5 times ULN (= 5 times ULN for tumor involvement of the liver)

• Creatinine = 2 times ULN

• Not pregnant or nursing

• Negative pregnancy test

• Fertile patients must use effective contraception

• No neuropathy = grade 1 with pain within the past 14 days

• No active infections

• No myocardial infarction within the past 6 months

• No NYHA class III or IV heart failure

• No uncontrolled angina

• No severe uncontrolled ventricular arrhythmias

• No evidence of acute ischemia or active conduction system abnormalities by ECG

• Any ECG abnormality at screening must be documented by the investigator as not medically relevant

• No hypersensitivity to bortezomib, boron, or mannitol

• No serious medical or psychiatric illness likely to interfere with study participation

PRIOR CONCURRENT THERAPY:

• Prior paclitaxel or bortezomib allowed

• At least 4 weeks since prior chemotherapy and/or radiotherapy

• More than 14 days since other prior investigational drugs

• No other concurrent investigational agents

• No other concurrent anticancer agents, including chemotherapy and biologic agents

• No concurrent recombinant interleukin-11 (Neumega®)

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Breast Cancer
• Colorectal Cancer
• Head and Neck Cancer
• Head and Neck Neoplasms
• Lung Cancer
• Melanoma (Skin)
• Ovarian Cancer
• Pancreatic Cancer
• Pancreatic Neoplasms
• Prostate Cancer
• Prostatic Neoplasms
• Unspecified Adult Solid Tumor, Protocol Specific

Intervention

Drug:
• bortezomib
Starting dose level 0.70mg/m2
• paclitaxel
Starting dose level 40mg/m2

Locations

Country	Name	City	State
United States	Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School	New Brunswick	New Jersey

Sponsors (2)

Lead Sponsor	Collaborator
University of Medicine and Dentistry of New Jersey	National Cancer Institute (NCI)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Maximum tolerated dose of paclitaxel in combination with bortezomib		2 years	Yes

External Links

•   Clinical trial summary from the National Cancer Institute's PDQ® database