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Head and Neck Neoplasms clinical trials

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NCT ID: NCT03878979 Not yet recruiting - Clinical trials for Head and Neck Cancer

Preoperative Immune Checkpoint Inhibitor for Patients With Recurrent or Metastatic SCCHN Undergoing Surgical Salvage

Start date: July 2019
Phase: Phase 2
Study type: Interventional

Nivolumab (also known as BMS-936558) before surgery to people with newly diagnosed or recurrent squamous cell carcinoma of head and neck (SCCHN).

NCT ID: NCT03875885 Not yet recruiting - Clinical trials for Head and Neck Cancer

CONNECTing Head and Neck Caregivers to Supportive Care Resources

CONNECT-HNC
Start date: May 31, 2019
Phase: N/A
Study type: Interventional

The purpose of this research is to determine feasibility and acceptability of randomized pilot trial to evaluate a technology-based intervention (CONNECT) to empower and educate caregivers about the benefits of supportive care resources, identify their unmet needs, and connect them with resources.

NCT ID: NCT03875833 Not yet recruiting - Clinical trials for Head and Neck Neoplasms

Prospective Analysis of Effect of Collagen Wrap Conduit on Radial and Ulnar Nerve Function Following Radial/Ulnar Forearm Free Flap Harvest

Start date: May 1, 2019
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether collagen nerve conduits placed on exposed radial and ulnar nerves during radial and ulnar forearm free flap harvests will reduce the occurrence and degree of sensory nerve deficit.

NCT ID: NCT03875716 Not yet recruiting - Clinical trials for Head and Neck Cancer

Study of Postoperative Radiation Therapy for HPV Associated Oropharyngeal Squamous Cell Carcinoma

Start date: April 30, 2019
Phase: N/A
Study type: Interventional

This research study is studying lowering the standard dose of radiation and chemotherapy after surgery, to minimize the side effects and improve the quality of life.

NCT ID: NCT03875053 Not yet recruiting - Clinical trials for Metastatic Head and Neck Squamous Cell Carcinoma

Home Sleep Apnea Machine in Evaluating Obstructive Sleep Apnea in Patients With Stage III-IV Head and Neck Cancer

Start date: March 20, 2019
Phase: N/A
Study type: Interventional

This trial studies information from a home sleep apnea machine to evaluate obstructive sleep apnea in patients with stage III-IV head and neck cancer. Sleep apnea (trouble breathing during sleep) can occur in head and neck cancer patients who have swelling in their neck. Wearing a sleep apnea machine overnight may help doctors evaluate obstructive sleep apnea in patients with head and neck cancer.

NCT ID: NCT03854838 Not yet recruiting - Clinical trials for Nasopharyngeal Carcinoma

IMRT Combined With Toripalimab in Unresectable Locally Recurrent Nasopharyngeal Carcinoma.

Start date: March 1, 2019
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the efficacy and safety of intensity-modulated radiation therapy combined with toripalimab in patients with the unresectable locally recurrent nasopharyngeal carcinoma.

NCT ID: NCT03853655 Recruiting - Clinical trials for Cancer of the Head and Neck

Adjuvant Radiotherapy in Early Stage Oral Cancers

AREST
Start date: August 2, 2018
Phase: N/A
Study type: Interventional

This study will assess the benefit of postoperative adjuvant radiotherapy in patients with an early oral squamous cell carcinoma (OSCC) having tumor thickness more than or equal to 5mm. The study population will consist of patients who have been treated by surgery for early stage oral tongue cancers. Patients with a close or positive margin (</= 5mm) and or with metastatic neck node(s) will be excluded. Selected patients will be randomized into two groups. The group I will be observed after surgery and group II will receive adjuvant radiotherapy as per protocol.

NCT ID: NCT03847480 Recruiting - Clinical trials for Head and Neck Cancer

Dose Painting of Head and Neck Cancer

RADPAINT
Start date: December 1, 2018
Phase: N/A
Study type: Interventional

Dose-painting may increase the chance of cure at minimised radiation-induced toxicity in volumetric-arc radiotherapy (VMAT) for head and neck cancer. This trial (RADPAINT) investigates the safety of FDG-PET guided radiotherapy using VMAT dose-painting by contours for patients with head and neck cancer of poor prognosis.

NCT ID: NCT03844763 Recruiting - Clinical trials for Head and Neck Cancer

Targeting the Tumor Microenvironment in R/M SCCHN

CONFRONT
Start date: January 7, 2019
Phase: Phase 1/Phase 2
Study type: Interventional

Phase I - II trial of the combination of cyclophosphamide, RT, and Avelumab in relapsed/metastatic HNSCC (R/M-HNC). Patients pretreated with at least one line therapy containing platinum, fluorouracil, and Cetuximab. Treatment consists of metronomic cyclophosphamide 50 mg daily without drug free break, avelumab 10 mg/kg d1 and 15 q 29, and radiotherapy in one or three daily fractions up to 8 Gy maximum dose, starting at day 8. The aim of the study is to reverse tumor immune-escape by: 1. Provide a self-vaccination with radiotherapy 2. Inhibit the immunosuppressive CD4+ CD25+ FoxP3+ Treg cells with metronomic cyclophosphamide 3. Reactivate the effector T cell by the inhibition of PD-1 - PD-L1 axis with avelumab. Due to the supposed biological effects of the present trial, an ancillary translational study is needed and will be extended to all the patients' population enrolled.

NCT ID: NCT03843671 Not yet recruiting - Clinical trials for Squamous Cell Carcinoma of the Head and Neck

Hyperbaric Radiation Sensitization of Head and Neck Cancers

Start date: July 1, 2019
Phase: Phase 2
Study type: Interventional

There is reason to believe that hyperbaric oxygen administered immediately prior to radiotherapy will prove beneficial for this cancer type and stage. The basis for this hypothesis is a review of several decades of published work, the conclusion of a recent (2018) Cochrane Review, and results of a Phase I trial.