Anaemia, Myocardial Ischaemia, Fractured Neck of Femur Clinical Trial
Official title:
Cardiac Injury and Anaemia Following Surgery for Fractured Neck of Femur: An Observational Study Study Protocol: Cardiac Injury and Anaemia Following Surgery for Fractured Neck of Femur: An Observational Study
Blood transfusion is an expensive and finite resource and optimum transfusion threshold in
surgical patients is yet to be defined. Patients commonly receive blood transfusions to
reduce the risk of myocardial ischaemia or improve perfusion of other organs (e.g. the
kidneys), but this treatment may have important adverse effects including postoperative
infection. Patients undergoing surgery for fractured neck of femur are often elderly, with
co-morbidities and a high risk of postoperative complications, including MI and AKI. We
propose to conduct a study with the following aims:
1. To describe the incidence of anaemia and transfusion in patients undergoing surgery for
fractured neck of femur.
2. To use clinical and biochemical data to measure the incidence of perioperative cardiac
and kidney injury in this group.
3. To evaluate highly sensitive serum troponin and urinary MALDI-MS as possible endpoints
in a future prospective randomised trial of perioperative transfusion.
Blood transfusion is an expensive and finite resource and optimum transfusion threshold in
surgical patients is yet to be defined. Patients commonly receive blood transfusions to
reduce the risk of myocardial ischaemia or improve perfusion of other organs (e.g. the
kidneys), but this treatment may have important adverse effects including postoperative
infection. There is great interest in restrictive transfusion practices (e.g. a transfusion
trigger of 70 g L-1), however patients with co-existing cardiovascular disease have been
excluded from studies of restrictive versus liberal transfusion strategies. Highly sensitive
troponin assays are now available, which allow clinicians to reliably detect cardiac injury
in increased numbers of patients who have undergone major surgery. Troponin release after
surgery is common, as high as 40% in some studies. Patients undergoing surgery for fractured
neck of femur are often elderly, with co-morbidities and a high risk of postoperative
complications, including MI and AKI. We propose to conduct a study with the following aims:
1. To describe the incidence of anaemia and transfusion in patients undergoing surgery for
fractured neck of femur.
2. To use clinical and biochemical data to measure the incidence of perioperative cardiac
and kidney injury in this group.
3. To evaluate highly sensitive serum troponin and urinary MALDI-MS as possible endpoints
in a future prospective randomised trial of perioperative transfusion.
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Observational Model: Cohort, Time Perspective: Prospective