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Clinical Trial Summary

A single-center, prospective, randomized, open-label, blinded end-point clinical trial of instantaneous wave-free ratio (iFR) guidance strategy impact on clinical outcomes in multivessel acute coronary syndrome (ACS) patients.


Clinical Trial Description

The "all-comers" study population consists of hemodynamically stable de novo ACS patients with a stenosis of 50% and more by visual estimation in at least two separate coronary arteries with Thrombolysis in Myocardial Infarction (TIMI) flow ≥ 2 and willing to sign a patient informed consent. ACS diagnosis established by angina pectoris symptoms and/or ECG changes and/or hs-troponin I levels. The use of drug-eluting stents is mandatory in both treatment groups. In the intervention strategy group, patients are treated by the iFR-guided percutaneous coronary intervention (PCI) in one stage. In the control group, patients are treated in accordance with the standard practice of angiography-guided staged approach. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05006183
Study type Interventional
Source Daugavpils Regional Hospital
Contact Deniss Vasiljevs, MD
Phone +37165440858
Email d.vasiljevs@siadrs.lv
Status Recruiting
Phase N/A
Start date August 8, 2019
Completion date September 2024

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