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Vomiting clinical trials

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NCT ID: NCT04719286 Completed - Clinical trials for Hyperemesis Gravidarum

MinSafeStart - Decision Aid Tool for Better Treatment of Nausea and Vomiting During Pregnancy

Start date: September 2, 2019
Phase: N/A
Study type: Interventional

Nausea and vomiting in pregnancy (NVP) is affecting up to 70% of pregnant women. Studies have also shown that NVP may have a profound impact on pregnant women's wellbeing and that even mild NVP symptoms have been shown to significantly reduce pregnant women's quality of life. However, NVP symptoms often occur during the first period of pregnancy where antenatal care not yet have been established. The objective of this project is to evaluate whether the "MinSafeStart" mobile application (app) can empower pregnant women to better self-manage NVP and hence improve their quality of life.

NCT ID: NCT04718727 Completed - Clinical trials for Postoperative Nausea

Olanzapine for the Prevention of Postoperative Nausea and Vomiting

Start date: March 15, 2021
Phase: Phase 1/Phase 2
Study type: Interventional

Nausea and vomiting (PONV) remain a common problem in surgical units. Even after two or three prophylactic antiemetic interventions, patients with all four of the Apfel risk factors for PONV have an estimated 30 to 40% chance of suffering PONV. Olanzapine as an antiemetic represents a new use of an antipsychotic drug.

NCT ID: NCT04715932 Completed - Pain Clinical Trials

Study of Hesperidin Therapy on COVID-19 Symptoms (HESPERIDIN)

Hesperidin
Start date: February 18, 2021
Phase: Phase 2
Study type: Interventional

The main aim of this study is to determine the effects of short-term treatment with hesperidin on COVID-19 symptoms in comparison with a placebo. Treatment effects will be observed through a symptoms diary that will be completed by participants throughout the study and by taking the oral temperature daily.

NCT ID: NCT04706897 Completed - PONV Clinical Trials

Opioid Sparing Anaesthesia for Prevention of Postoperative Nausea and Vomiting in Laparoscopic Gynecological Surgery

Start date: January 15, 2021
Phase: Phase 4
Study type: Interventional

In spite of multimodal analgesic strategies, which consist of opioids, dexamethasone, non-steroidal anti-inflammatory drugs, and local anesthetics applied into the surgical wound, postoperative pain and postoperative nausea and vomiting (PONV) are still common complaints reported after laparoscopic gynecological surgery. So, it is hypothesized that the infusion consisting of lidocaine, dexmedetomidine and ketamine, as an opioid substitute was a feasible technique for laparoscopic gynecological surgery and would be associated with less incidence of PONV and lower opioid requirements in the early postoperative period. The aim of this study was to evaluate the effect of opioid sparing technique via infusion of Dexmedetomidine, Ketamine and Lidocaine on post-operative nausea and vomiting in laparoscopic gynecological surgery.

NCT ID: NCT04693832 Completed - Oncology Clinical Trials

The Effect of Using Interactive Mobile Application for the Management of Chemotherapy- Induced Nausea and Vomiting in Children

Start date: January 1, 2019
Phase: N/A
Study type: Interventional

The aim of this study was to develop an interactive mobile application and to investigate the effect of this application on the management of nausea and vomiting symptoms by using it during chemotherapy treatment.

NCT ID: NCT04669132 Completed - Clinical trials for Nausea Post Chemotherapy

Efficacy of Olanzapine, Netupitant and Palonosetron in Controlling Nausea and Vomiting Associated With Highly Emetogenic Chemotherapy in Patients With Breast Cancer

OLNEPA
Start date: December 17, 2020
Phase: Phase 2
Study type: Interventional

This is a longitudinal, one arm, prospective phase II study, designed to evaluate the efficacy of Olanzapine Netupitant and Palonosetron in the controll of nausea and vomiting induced by highly emetogenic chemotherapy.

NCT ID: NCT04651608 Completed - Pediatric Cancer Clinical Trials

The Effect of Acupressure Chemotherapy-related Nausea Vomiting in Children

Start date: March 1, 2017
Phase: N/A
Study type: Interventional

This study is carried out to evaluate and compare the efficiency of acupressure practice applied with pressure or sea-band and their placebo on managing the acute nausea-vomiting symptoms developing due to chemotherapy in pediatric oncology patients.

NCT ID: NCT04645953 Completed - Clinical trials for Cyclic Vomiting Syndrome

Staccato Granisetron® (AZ 010) for the Treatment of Cyclic Vomiting Syndrome

Start date: February 11, 2021
Phase: Phase 2
Study type: Interventional

This is a multicenter, randomized, double-blind, parallel group, placebo-controlled, efficacy and safety study of adult outpatients diagnosed with CVS and experiencing recurring episodes of stereotypical vomiting.

NCT ID: NCT04622618 Completed - Pain, Postoperative Clinical Trials

Optimal Dosing of Preoperative Gabapentin for Prevention of Postoperative Nausea and Vomiting

Start date: September 15, 2020
Phase: Early Phase 1
Study type: Interventional

Overall incidence of postoperative nausea and vomiting (PONV) after general anesthesia is 40-90 % . gabapentin has been incorporated into "fast-track" packages and improved recovery during surgery protocols to avoid unintended side effects associated with opioid alternatives. Interestingly, gabapentin has also been noted to reduce the effects of chemotherapy-induced nausea, effective in treatment of gravidarum hyperemesis, and postdural puncture emesis. Different dosing regimens were tested.The goal of the study is to determine the most effective dose of oral gabapentin given 1 hour prior to surgery on the occurrence and severity of PONV and drug side effects in the first 24 hours postoperatively to find the most effective dose of gabapentin with the least side effects.

NCT ID: NCT04613726 Completed - Clinical trials for Postoperative Complications

The Effect of Intravenous Granisetron and Ondansetron in Patients Undergoing Cesarean Section

Start date: December 3, 2018
Phase: Phase 3
Study type: Interventional

This study compared the effects of prophylactic intravenous (IV) infusion of ondansetron and granisetron before the spinal anesthesia on hemodynamic parameters in patients undergoing elective cesarean section.