Olanzapine for the Prevention of Postoperative Nausea & Vomiting

Status Completed

Clinical Trial Summary

Nausea and vomiting (PONV) remain a common problem in surgical units. Even after two or three prophylactic antiemetic interventions, patients with all four of the Apfel risk factors for PONV have an estimated 30 to 40% chance of suffering PONV. Olanzapine as an antiemetic represents a new use of an antipsychotic drug.

Clinical Trial Description

Aim of the Research, to compare the effects of oral 10 and 5 mg Olanzapine for the Prevention of Postoperative Nausea and Vomiting ;

Study Design

Related Conditions & MeSH terms

Nausea
Postoperative Nausea
Postoperative Nausea and Vomiting
Vomiting

Clinical Trial Details

NCT number	NCT04718727
Study type	Interventional
Source	Assiut University
Contact
Status	Completed
Phase	Phase 1/Phase 2
Start date	March 15, 2021
Completion date	February 1, 2023

View Details

See also
Status	Clinical Trial	Phase
Not yet recruiting	`NCT03639012` - Outcomes of Carbohydrate Loading Paediatric Patients Preoperatively for Tonsillectomy and Adenoidectomy	N/A
Not yet recruiting	`NCT01389570` - Postoperative Nausea/Vomiting and Acupressure	Phase 2
Completed	`NCT00830089` - Trial of a Transversus Abdominis Plane (TAP) Block in Laparoscopic Colorectal Surgery	N/A
Terminated	`NCT05112575` - Evaluation of Patient Stress Level Caused by Radiological Investigations in Early Postoperative Phase After Craniotomy
Completed	`NCT04759079` - The Effects of Acupuncture Against Postoperative Nausea and Vomit After Laparoscopic Cholecystectomy	N/A
Active, not recruiting	`NCT03712891` - Evaluation of Providing Coffee to Patients Postoperatively to Decrease Length of Stay in the PACU	N/A
Completed	`NCT01834898` - Safety and Tolerability of Controlled-release Oxycodone on Postoperative Pain in Oncologic Head and Neck Surgery	N/A
Completed	`NCT03631004` - Pre-operative Olanzapine as Prophylactic Antiemetic in Oncologic Patients	Phase 2/Phase 3
Active, not recruiting	`NCT05618236` - Sugammadex and Neostigmine in Pediatric Patients
Not yet recruiting	`NCT05632224` - Postoperative Nausea and Vomiting in Laparoscopic Abdominal Surgery	Phase 4
Completed	`NCT01020903` - Aprepitant for Post-operative Nausea	N/A
Completed	`NCT00793663` - Depth of Hypnosis and Postoperative Nausea and Vomiting During Xenon Anaesthesia	Phase 4
Completed	`NCT03503292` - Pharmacogenomics and Post-Operative Nausea and Vomiting	Phase 4
Completed	`NCT05841693` - Quality of Recovery in Parturients Consumed Preoperative Carbohydrate Fluid for Elective Cesarean Delivery	Phase 4
Completed	`NCT04742660` - The Effect of Glycyrrhizin on the Occurrence of Postoperative Nausea and Vomiting	N/A
Completed	`NCT03100669` - Implementing a Postoperative MIRP (Minimally Invasive Repair of Pectus) Program Via Tele-monitoring
Terminated	`NCT02765750` - Postoperative Outcomes After Positive Intraoperative Messages	N/A
Terminated	`NCT01798316` - IV Acetaminophen for Postoperative Analgesia	Phase 4
Completed	`NCT03387956` - Intrathecal Atropine to Prevent Postoperative Nausea and Vomiting	N/A
Completed	`NCT01116713` - Effect of Dexamethasone in Postoperative Symptoms After Mastectomy for Breast Cancer	Phase 3