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Vascular Stiffness clinical trials

View clinical trials related to Vascular Stiffness.

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NCT ID: NCT06419959 Not yet recruiting - Clinical trials for Cardiovascular Diseases

NightWare and Cardiovascular Health in Veterans With PTSD

Start date: October 1, 2024
Phase: N/A
Study type: Interventional

The purpose of this study is to learn more about the effectiveness of a prescription wrist-wearable device called NightWare (NW) on improving sleep in Veterans with nightmares related to posttraumatic stress disorder (PTSD). The investigators also want to learn whether it improves cardiovascular health among this population.

NCT ID: NCT06345443 Not yet recruiting - Vascular Stiffness Clinical Trials

NRM on Vascular Perfusion in Healthy Adults

NRM
Start date: June 15, 2024
Phase: N/A
Study type: Interventional

The purpose of this study is to better understand the effects of nicotinamide riboside supplement in overall cardiovascular health in healthy adults.

NCT ID: NCT06117007 Recruiting - Quality of Life Clinical Trials

Effects of Betalains on Cardiovascular Health and Quality of Life

Start date: October 30, 2023
Phase: N/A
Study type: Interventional

The goal of this randomized, double-blind, placebo-controlled, cross-over trial is to investigate the effects of beetroot-derived betalains on cardiovascular health, sleep and quality of life in healthy middle-aged individuals. The main question[s] it aims to answer are: - Do betalains improve vascular function? - Do betalains improve sleep? - Do betalains improve quality of life? Participants will be involved with the following: - Consuming a daily betalain-rich or placebo capsule for a month - Non-invasive cardiovascular measurements - Wearing a fitness tracker for tracking physical activity and sleep - Answering questionnaires regarding quality of life Researchers will compare results between the intervention versus the placebo group to see if any of the study outcomes are significantly different.

NCT ID: NCT06071728 Completed - Aging Clinical Trials

Restoring Glycocalyx Thickness in Older Adults to Improve Vascular Function

RESTORE
Start date: October 10, 2022
Phase: N/A
Study type: Interventional

The glycocalyx serves as the interface between flowing blood and endothelial cells, the single cell layer that lines blood vessels, and is crucial for normal blood vessel function. Specifically, the glycocalyx protects endothelial cells from oxidative stress and inflammation and enables blood vessel dilation, which is largely dependent on the bioavailability of the vasodilatory molecule nitric oxide. Importantly, glycocalyx thickness decreases with age and is predictive of major adverse cardiovascular events in older adults free of cardiovascular disease. Therefore, interventions aimed at restoring glycocalyx thickness in older adults are desperately needed. Endocalyx Pro is a commercially available glycocalyx precursor supplement, manufactured by Microvascular Health Solutions, designed to 1) repair a damaged glycocalyx, 2) protect against damage to the glycocalyx, and 3) synthesize new glycocalyx components, and has been used to increase glycocalyx thickness in humans. However, no study has tested if glycocalyx thickness restores glycocalyx thickness in older adults and improves blood vessel function. Thus, the purpose of this investigation is to determine if 12-weeks of Endocalyx Pro supplementation alters glycocalyx thickness and blood vessel function in older adults. The investigators will use a camera placed under the tongue to determine glycocalyx thickness. The investigators will measure blood vessel function by measuring brachial artery dilation with ultrasound and arterial stiffness using pressure probes placed on the carotid and femoral artery.

NCT ID: NCT05823025 Not yet recruiting - Vascular Stiffness Clinical Trials

Withings Study to Analyze the Accuracy of Pulse Wave Velocity Measurement With Bathroom Scales (WIVOP-Scales)

WIVOP-Scales
Start date: May 2, 2023
Phase:
Study type: Observational

The aim of this study is to evaluate the diagnostic performance of Withings bathroom scales WBS08 and WBS12 to measure PWV (Pulse Wave Velocity).

NCT ID: NCT05701943 Completed - Vascular Stiffness Clinical Trials

Comparison of Home- vs. Gym-based Exercise Delivery Modes

UPSIDE DOWNS
Start date: November 2, 2020
Phase: N/A
Study type: Interventional

Home-based exercise interventions were the only alternatives to attenuate physical deconditioning and ameliorate traditional and emergent cardiovascular risk factors progression during the COVID-19 outbreak. Benefits in physical and psychological health have only been reported in adults without intellectual and developmental disability (IDD). The purpose of this study is to compare home vs gym-based delivery exercise modes of two 8-week supervised aerobic training regimes on cardiorespiratory fitness and arterial structure and stiffness in adults with IDD. It is hypothesized that home- and gym- based exercise delivery modes will be equally effective in improving cardiorespiratory fitness and overall arterial heath, although in an intensity dependent manner. A secondary analysis examining changes in blood pressure and body composition will be performed.

NCT ID: NCT05553223 Recruiting - Hypertension Clinical Trials

Micro-doses of Physical Activity for COPD

COPD
Start date: October 12, 2022
Phase: N/A
Study type: Interventional

Chronic obstructive pulmonary disease (COPD) is a disease of the lungs that makes it hard for people to breath. Those with COPD spend considerably more time sitting and lying and less time performing physical activity than healthy individuals. Those who are the most sedentary have a greater risk of heart and blood vessel disease, which may lead to an early death. This project will investigate the effect of sitting still for 3 hours on blood vessel health in individuals with COPD. It will also investigate whether breaking up the amount of time patients sit with regular short bouts of walking (5 minutes each hour) at a comfortable pace chosen by the patient can have a positive effect on maintaining the health of their blood vessels. It is hypothesized that blood vessel health will be worse after 3 hours of sitting compared to when the sitting is broken up by short bouts of walking.

NCT ID: NCT05424263 Recruiting - Aging Clinical Trials

Acetate and Age-associated Arterial Dysfunction

Start date: September 29, 2022
Phase: Phase 2
Study type: Interventional

Cardiovascular diseases are the leading cause of morbidity and mortality and contribute most to healthcare costs in the U.S. Age is the strongest cardiovascular disease risk factor, with >90% of all deaths from cardiovascular disease occurring in adults >50 years old. The age-associated increased risk of cardiovascular disease is due, in large part, to the development of arterial dysfunction, including endothelial dysfunction and stiffening of the large elastic arteries. Therefore, novel, effective interventions that improve arterial function will have a large public health impact by decreasing the risk of cardiovascular diseases. The short-chain fatty acid acetate is endogenously produced by the gut microbiome from fermentation of dietary soluble fiber. High-fiber diets reduce risk of cardiovascular diseases, but unfortunately, a low percentage of Americans meet guidelines for adequate dietary fiber intake and, despite nationwide efforts to improve this, trends in fiber intake have not improved over the last 20+ years. Thus, directly supplementing acetate may be a more practical and feasible intervention for effectively improving arterial function in older adults and reducing the risk of cardiovascular diseases. The investigators will conduct a study to determine the efficacy of 12 weeks of oral supplementation with acetate for improving arterial function in late middle-aged and older (50+ years) adults. They will also assess the safety and tolerability of acetate supplementation in these adults and perform innovative mechanistic analyses to determine how acetate supplementation improves arterial function. The investigators hypothesize that oral acetate supplementation will improve arterial function by decreasing oxidative stress and increasing nitric oxide bioavailability, and also hypothesize that acetate supplementation will be safe and promote high rates of adherence.

NCT ID: NCT05388032 Recruiting - Clinical trials for Endothelial Dysfunction

Sodium Lowering Vascular Effects Trial

SOLVE
Start date: January 25, 2023
Phase: N/A
Study type: Interventional

The proposed mechanistic trial will test the effect of dietary sodium reduction on cardiac and vascular structure and function in those with elevated blood pressure or hypertension. Findings from this study will fill the knowledge gap on the underlying mechanisms of dietary sodium intake on cardiovascular disease risk in addition to blood pressure and could provide further evidence on sodium reduction for the prevention of cardiovascular disease.

NCT ID: NCT05365607 Recruiting - Clinical trials for Cardiovascular Diseases

NightWare and Cardiovascular Health in Adults With PTSD

Start date: June 24, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether NightWare therapeutic intervention improves biomarkers of vascular aging and autonomic function in adults with nightmares related to PTSD.