Coronary Artery Disease Clinical Trial
Official title:
Evaluation of the Brain Natriuretic Peptide as a Predictor of Morbidity and Mortality in Cardiac Surgery
Objective: The purpose of the present study is to assess if perioperative variation of Brain
Natriuretic Peptide (BNP) levels is a predictor of mortality and morbidity after cardiac
surgery.Material and Methods: 500 consecutive patients will be enrolled prospectively in
this study before cardiac surgery under cardiopulmonary bypass. BNP levels will be measured
prior to surgery and at postoperative day 1. Variations of BNP levels will be analyzed to
determine if it is a predictor of mortality and morbidity after cardiac surgery. This
dynamic evaluation will be compared to other tools of risk stratification in cardiac surgery
as the EuroScore. All patients will be followed 3 years after the procedure.
Hypothesis: Perioperative BNP variations may be more sensitive than pre- or postoperative
BNP levels alone. Furthermore the perioperative homeostasis will be measured to assess its
impact on BNP secretion during the perioperative period.
n/a
Observational Model: Case-Only, Time Perspective: Prospective
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