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Valvular Disease clinical trials

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NCT ID: NCT04575857 Active, not recruiting - Clinical trials for Rheumatic Heart Disease

Role of Statins In Slowing Rheumatic Heart Disease (RHD) Progression

Start date: February 8, 2022
Phase:
Study type: Observational

The goal of this study is to address specific implementation questions necessary and sufficient to ensure the feasibility of the larger randomized trial examining the efficacy of statin medications in slowing rheumatic heart disease (RHD) valvular pathology progression. This feasibility study is intended to confirm the number of readily recruitable subjects, assess recruitment rate, and assess the rate of valve pathology via echocardiograms. These results are necessary and sufficient to facilitate the successful design of a large full scale randomized trial to determine whether statins improve outcomes in RHD. Successful treatment of RHD would fundamentally shift the RHD management paradigm world-wide, improve the lives of millions afflicted with RHD, and subsequently, decrease health care spending on RHD management.

NCT ID: NCT04527367 Completed - Clinical trials for Coronary Artery Disease

Epidemiology and Long-term Outcome of Patients With VHD

BIA-WAD
Start date: January 2006
Phase:
Study type: Observational

Valvular heart diseases are significant problem in Polish population. Coexistence of coronary artery disease in patients with VHD increases the risk of death and affects further therapeutic strategy. The aim of the study is analysis the epidemiology and the long-term prognosis among patients with VHD.

NCT ID: NCT04220450 Not yet recruiting - Heart Failure Clinical Trials

T1-mapping by Cardiovascular Magnetic Resonance Imaging to Assess Non-Alcoholic Fatty Liver Disease

Start date: June 1, 2020
Phase:
Study type: Observational

On clinically indicated Cardiovascular Magnetic Resonance studies, native T1-times and extracellular volume of the liver will be assessed and findings correlated with established risk calculators for non-alcoholic fatty liver disease.

NCT ID: NCT03887286 Completed - Clinical trials for Ventricular Dysfunction

Focused Cardiac Ultrasound

Start date: April 1, 2019
Phase: N/A
Study type: Interventional

To compare the images from standard cardiac ultrasound with images from a small hand-held device; to find out more about the feasibility and accuracy of a small hand-held ultrasound device.

NCT ID: NCT03834155 Recruiting - Clinical trials for Coronary Artery Disease

Enhancing Cardiac Rehabilitation Through Behavioral Nudges

Start date: May 1, 2019
Phase: N/A
Study type: Interventional

Adherence to cardiac rehabilitation is poor, and worse for minorities, women, and those with lower levels of education. Patients less likely to be referred to and complete cardiac rehab are at highest risk of adverse outcomes and thus have the most to gain from participation in cardiac rehab. To improve participation, healthcare systems need to limit barriers to enrollment and promote adherence to rehabilitation.

NCT ID: NCT01727310 Completed - Valvular Disease Clinical Trials

Filling Pressures of the Left Ventricle in Patients With Significant Aortic Stenosis

PRESSEVAL
Start date: November 2012
Phase: N/A
Study type: Observational

Left valvular heart disease has become one of the most common heart disease in Western countries. This disease evolve over many years and are characterized by a long phase where the patient is "asymptomatic". it is characterized by discomfort LV filling may worsen and lead typically to a pressure increase of LV pressure and the left atrium (LA) (1). The onset of symptoms is unpredictable and may occur at the stage of diastolic or systolic dysfunction. Ventricular dysfunction may be insidious, the goal is to detect early dysfunction, knowing that it is often very difficult to know if the patient is actually symptomatic. The onset of symptoms sign an intolerance to the increase in LV filling pressures and LA , causing pulmonary hypertension . Therefore, the study of the level of LV and LA filling pressures , if possible by a noninvasive method, would identify patients apparently asymptomatic even though their condition is advanced. Pressures filling pressures can be explored by two methods: - cardiac catheterization, which is a direct and invasive measurement method - echocardiography, which is an indirect measurement method which has the advantage of being non-invasive The goal of this research is to compare the two methods.

NCT ID: NCT00699673 Active, not recruiting - Clinical trials for Coronary Artery Disease

Evaluation of the Brain Natriuretic Peptide as a Predictor of Morbidity and Mortality in Cardiac Surgery

Start date: June 2008
Phase: N/A
Study type: Observational

Objective: The purpose of the present study is to assess if perioperative variation of Brain Natriuretic Peptide (BNP) levels is a predictor of mortality and morbidity after cardiac surgery.Material and Methods: 500 consecutive patients will be enrolled prospectively in this study before cardiac surgery under cardiopulmonary bypass. BNP levels will be measured prior to surgery and at postoperative day 1. Variations of BNP levels will be analyzed to determine if it is a predictor of mortality and morbidity after cardiac surgery. This dynamic evaluation will be compared to other tools of risk stratification in cardiac surgery as the EuroScore. All patients will be followed 3 years after the procedure. Hypothesis: Perioperative BNP variations may be more sensitive than pre- or postoperative BNP levels alone. Furthermore the perioperative homeostasis will be measured to assess its impact on BNP secretion during the perioperative period.

NCT ID: NCT00484380 Completed - Coronary Stenosis Clinical Trials

The Scanner in the Coronary Evaluation

Start date: August 2007
Phase: N/A
Study type: Interventional

Conventional coronary angiography is the recommended procedure in detection of coronary stenosis in patients with heart valve disease referred for surgery.The aim of this prospective study is to assess diagnostic accuracy of multislice spiral computed tomography coronary angiography in patients with heart valve disease referred for surgery.