Type 2 Diabetes Clinical Trial
— EGPT2D&CHFOfficial title:
The Effects of Glimepiride in Patients With Type 2 Diabetes and Chronic Heart Failure
Verified date | September 2022 |
Source | Tongji Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational [Patient Registry] |
Thirty years ago, Dzau and Braunwald introduced the concept of a continuum of cardiovascular diseases and defined them as a series of events caused by numerous related and unrelated risk factors, thus developing to end-stage heart disease through many pathophysiological pathways and processes. Owing to treatment concept changes and the urgency of investigating T2D combined with CHF, SUs are being re-evaluated, of which glimepiride is undoubtedly the most promising.
Status | Completed |
Enrollment | 1018 |
Est. completion date | July 1, 2022 |
Est. primary completion date | June 1, 2022 |
Accepts healthy volunteers | |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Chronic heart failure (>6 months duration, according to 2021 ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure) - Reduced ejection fraction defined as LVEF < 50% - N-terminal pro-brain natriuretic peptide (NT-proBNP) level: >125 pg/mL - NYHA-class II/III/IV with stable symptoms for at least the past 3 months - Type 2 diabetes (according to the Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2022) Exclusion Criteria: - Those who did not meet the diagnostic criteria - Lacked echocardiographic and NT-proBNP data - Used sulfonylureas other than glimepiride were excluded |
Country | Name | City | State |
---|---|---|---|
China | Tongji Hospital | Wuhan | Hubei |
Lead Sponsor | Collaborator |
---|---|
Dao Wen Wang | Shanghai Institute of Materia Medica, Chinese Academy of Sciences |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Cardiovascular mortality | Numbers and dates of death due to cardiovascular diseases in each group | 5 years | |
Primary | Hospitalizations and emergency visits for heart failure | Numbers and dates of hospitalizations and emergency for heart failure | 5 years | |
Secondary | All-cause mortality | Numbers and dates of death in each group | 5 years | |
Secondary | Hospitalizations for acute myocardial infarction or stroke | Numbers and dates of hospitalizations for acute myocardial infarction or stroke | 5 years |
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