Clinical Trials Logo

Clinical Trial Summary

Globally, 10 million new traumatic brain injury (TBI) cases are estimated annually, with mild traumatic brain injury (mTBI) accounting for 75-90% of all TBI cases. It is estimated that 40-80% of individuals with mTBI may experience the post-concussion syndrome (PCS), which is characterized by a range of physical, cognitive, and emotional symptoms. Although the underlying basis of cognitive dysfunction of patients with persistent PCS remains to be clarified, converging evidence shows that the clinical symptoms is underpinned by abnormal neural information processing as a result of axonal injury due to mTBI. Recent studies have demonstrated abnormalities in both structural and functional cortical connectivity, and a loss of cortical excitability-inhibitory (E/I) balance after TBI. Yet, there is no consensus for treating chronic symptoms of concussion, and PCS remains a chronic and highly disabling condition. One potential treatment option is transcranial direct current stimulation (tDCS), a non-invasive brain stimulation technique that has been shown to modify behavior by enhancing connectivity between targeted brain areas. However, research on the therapeutic effect of tDCS on PCS symptoms is limited, and the neurologic mechanisms underlying its effects are not well understood. The proposed study aims to address these knowledge gaps by examining the effects of tDCS on the central nervous system function in patients with PCS, with a specific focus on functional cortical connectivity and cognitive functions such as processing speed and executive function. The study also aims to add value to existing evidence by potentially opening new directions for designing intervention programs for the treatment of PCS after mTBI.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT06376500
Study type Interventional
Source The Hong Kong Polytechnic University
Contact Yvonne Han, PhD
Phone +852 2766 7578
Email yvonne.han@polyu.edu.hk
Status Not yet recruiting
Phase N/A
Start date June 2024
Completion date February 2028

See also
  Status Clinical Trial Phase
Completed NCT04101695 - Hemodynamic Response of Anodal Transcranial Direct Current Stimulation Over the Cerebellar Hemisphere in Healthy Subjects N/A
Completed NCT04504344 - Non-invasive Brain Stimulation to Improve Quadriceps Muscle Function After Anterior Cruciate Ligament Reconstruction Phase 1
Recruiting NCT06193278 - Individual Neuromodulation for PDS N/A
Recruiting NCT06148363 - Intervention Effect of High-Definition Transcranial Direct Current Stimulation (HD-tDCS) on Non-suicidal Self-injury (NSSI) N/A
Active, not recruiting NCT05293431 - Promote Brain Resilience for the Coronavirus (COVID-19) Pandemic N/A
Recruiting NCT04997226 - Cognitive Enhancement in Healthy Elderly People N/A
Active, not recruiting NCT04159012 - NESBID: Neuro-Stimulation of the Brain in Depression N/A
Completed NCT04226417 - Effect of Home Based Transcranial Direct Current Stimulation (tDCS) With Exercise on Upper and Lower Limb Motor Functions in Chronic Stroke N/A
Active, not recruiting NCT02959502 - Home-Based CR and tDCS to Enhance Cognition in Persons With Mild Cognitive Impairment and Late Life Depression N/A
Not yet recruiting NCT05467566 - Transcranial Direct Current Stimulation Combined With Exercise in Low Back Pain N/A
Completed NCT03050385 - Cognitive Rehabilitation During Transcranial Direct Current Stimulation N/A
Completed NCT02287207 - Effects of Transcranial Direct Current Stimulation on Fine Motor Skills in Parkinson's Disease: a Pilot Study N/A
Recruiting NCT03635008 - Anodal Transcranial Direct Current Stimulation Over the Contralesional Hemisphere on Motor Recovery in Subacute Stroke Patients N/A
Completed NCT04117256 - Transcranial Versus Suboccipital Direct Current Stimulation N/A
Completed NCT04328545 - Transcranial Direct Current Stimulation Effect on Pain Threshold and Working Memory: Impact of Age and Protocol Type N/A
Completed NCT04697901 - Sustaining Aviator Performance During Extended Operational Flight N/A
Active, not recruiting NCT03655769 - fMRI Analysis of Aging and Awareness in Conditioning N/A
Completed NCT03680664 - Mindfulness-Based Stress Reduction (MBSR) and Transcranial Direct Current Stimulation (tDCS) N/A
Recruiting NCT04052399 - Improving Insulin Sensitivity by Non-invasive Brain Stimulation in Persons With Insulin Resistance N/A
Completed NCT06110936 - Effects of Transcutaneous Spinal Direct Current Stimulation on Mobility in Cases With Multiple Sclerosis N/A