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Tinnitus clinical trials

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NCT ID: NCT02095262 Completed - Tinnitus Clinical Trials

Gameplay as a Source of Intrinsic Motivation in a Randomized Controlled Trial of Auditory Training for Tinnitus

TAG
Start date: August 2011
Phase: Phase 1/Phase 2
Study type: Interventional

Tinnitus refers to a the perception of a ringing, hissing or buzzing sound despite there being no such sound in the external world. It is prevalent and for many individual is a distressing condition. Recent advances in the understanding of changes in the hearing brain and their relation to tinnitus perception has led to a focus on forms of active auditory training which might provide effective techniques for tinnitus management. Our recent trial of auditory training provided evidence that training using sounds where there is no hearing loss has benefit in terms of reduced tinnitus intrusiveness, above training at where there is some level of hearing loss. Our next challenge is to build on this finding in ways that might maximize the benefits we observe. The training software we used previously was developed for use with children. Past participants have given mixed reviews of this software. While some enjoyed the training or found it soporific, others reported that they found it too monotonous and un-motivating. We therefore wish to explore the impact of different game mechanics in the delivery of auditory training and have designed two different interactive games in the context of training for tinnitus benefit. These games will deliver the same type of auditory training as the software we currently use, but should be intrinsically motivating, i.e. be a game that the people are motivated to play irrespective of any potential benefit for tinnitus. The game we previously used is reactive, i.e. the sounds play and the player selects what they think is the correct answer (odd one out). The two new games we wish to test can be described as interactive, i.e. players control the sound delivery and actively seek the correct answer: this may have additional benefit for tinnitus.

NCT ID: NCT02088866 Completed - Tinnitus Clinical Trials

Commercial Lidocaine Patch as a Treatment for Ear-ringing

Start date: March 2014
Phase: Early Phase 1
Study type: Interventional

The purpose of this investigation is to evaluate if topically applied lidocaine, in the form of lidocaine patches, reduces the burden of chronic subjective tinnitus in a consistent and measurable way.

NCT ID: NCT02071732 Completed - Clinical trials for Patients With Subjective Tinnitus

Therapeutic Effect of Repetitive Transcranial Magnetic Stimulaton on Tinnitus

Start date: February 2014
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether repetitive transcranial magnetic stimulation (rTMS) is effective in the treatment of tinnitus.

NCT ID: NCT02062333 Completed - Clinical trials for Anesthesia; Adverse Effect

The Effects of the Drugs Used in Hypotensive Anaesthesia on Cochlea

Start date: January 2014
Phase: Phase 4
Study type: Interventional

The aim of this study is to find the Effects of Anesthetics Used in Hypotensive Anesthesia on Stapes Reflex and Distortion Product Auto Acoustic Emission.

NCT ID: NCT02059447 Completed - Tinnitus Clinical Trials

A Comparison of the Benefits of Mindfulness Based Cognitive Therapy, Relaxation Therapy and a Waiting List Control in the Management of Distress in Chronic Tinnitus Patients

Start date: December 2013
Phase: N/A
Study type: Interventional

The principal hypotheses to be tested is that Mindfulness Based Cognitive Therapy (MBCT) reduces the distressing impact of tinnitus to a significantly greater extent than a waiting list control or relaxation therapy. This study is a mixed design, with two groups assessed at a number of time points. The primary outcome measure will be that of tinnitus distress, and secondary outcomes will be taken of psychological distress and tinnitus loudness. The outcome measures will be measured first at 8 weeks pre-treatment. All subjects then wait for 8 weeks before being randomly allocated to either an 8 week course of Mindfulness-Based Cognitive Therapy (MBCT) (Group 1) or an 8 week course of Relaxation Therapy (RT) (Group 2). All participants will be assessed at two main time-points (pre and post-treatment). The outcome measures will be repeated at 1 and 6 month follow-up points.

NCT ID: NCT02040207 Completed - Tinnitus Clinical Trials

AM-101 in the Treatment of Post-Acute Tinnitus 2

AMPACT2
Start date: June 2014
Phase: Phase 3
Study type: Interventional

The purpose of this research study is to test the safety and local tolerance of repeated treatment with AM-101.

NCT ID: NCT02040194 Completed - Tinnitus Clinical Trials

AM-101 in the Treatment of Acute Tinnitus 3

TACTT3
Start date: January 2014
Phase: Phase 3
Study type: Interventional

The purpose of this research study is to test the safety and effectiveness of the study drug, AM-101. AM-101 is tested for the treatment of tinnitus that started as the result of an injury to the inner ear or due to middle ear inflammation (otitis media). Subjects with tinnitus can take part in the study, if their tinnitus started within the last 3 months or within the last >3 to 6 months.

NCT ID: NCT02016313 Completed - Tinnitus Clinical Trials

The Effect of Physiotherapy on Cervicogenic Somatic Tinnitus

Start date: May 2014
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether physiotherapy is effective in the treatment of a group of tinnitus patients with neck complaints.

NCT ID: NCT01988688 Completed - Tinnitus Clinical Trials

Pilot Study of Deep Brain Stimulation (DBS) in Area LC for Chronic Tinnitus

Start date: January 2014
Phase: Phase 1
Study type: Interventional

This study will test the safety and effectiveness of deep brain stimulation (DBS) for patients with a big or very big problem with tinnitus (a sensation of noise in the head).

NCT ID: NCT01965028 Completed - Chronic Tinnitus Clinical Trials

Daily Bi-temporal Transcranial Random Noise Stimulation in Tinnitus

tRNS-tin
Start date: October 2013
Phase: N/A
Study type: Interventional

Stimulation of the left and right auditory cortex with daily transcranial random noise stimulation (tRNS) is used to modulate the neural pathways involved in chronic tinnitus.