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Tinnitus clinical trials

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NCT ID: NCT02383147 Completed - Clinical trials for Tinnitus, Subjective

Efficacy Study for Development and Use of Neurofeedback-trainings for Patients Suffering From Chronic Tinnitus

Start date: March 2015
Phase: N/A
Study type: Interventional

Chronic tinnitus affects about 10-15% of the population in industrialized countries. Investigations of the brain activity by using electroencephalography (EEG) showed that in localized regions of the hearing system brain activity was decreased. This reduction of activity is thought to be one of the reasons that keep the perception of the tinnitus going. Recent studies have shown that neurofeedback is a viable option for treatment of chronic tinnitus. By using neurofeedback it is possible to train brain functions by the simple principle of rewarding wanted changes and punishing unwanted ones. The purpose of the investigators study is to show the efficacy of specific localized neurofeedback training in comparison to global relaxing neurofeedback training. In order to achieve decreased tinnitus symptoms or even disappearance of the tinnitus, 15 neurofeedback trainings are planned. Before and up to 6 month after the training EEG-recordings are performed.

NCT ID: NCT02370810 Completed - Tinnitus Clinical Trials

A CBT-based Internet Intervention for Adults With Tinnitus in the United Kingdom

Start date: January 2016
Phase: N/A
Study type: Interventional

The purpose of this study is to determine the feasibility and effectiveness of a CBT-based internet intervention for adults with tinnitus in the United Kingdom

NCT ID: NCT02315508 Completed - Clinical trials for Tinnitus, Subjective

Evaluating Possible Improvement in Tinnitus Severity After 28 Days Dosing of the Study Drug AUT00063 Compared to Placebo

QUIET-1
Start date: October 2014
Phase: Phase 2
Study type: Interventional

This study aims to demonstrate that the new medicine AUT00063 is effective and safe in the treatment of tinnitus.

NCT ID: NCT02306447 Completed - Chronic Tinnitus Clinical Trials

Combined Transcranial and Peripheral Muscle Magnetic Stimulation in Chronic Tinnitus

rpms-tinn
Start date: August 2014
Phase: N/A
Study type: Interventional

Magnetic stimulation of the brain (repetitive transcranial magnetic stimulation) and of neck muscles (repetitive peripheral muscle stimulation) is used to alter tinnitus-related cortical activity and neck muscles tension.

NCT ID: NCT02293512 Completed - Tinnitus Clinical Trials

A Comparison of Three Psychoeducational Group Interventions for Veterans With Tinnitus

Start date: September 1, 2015
Phase: N/A
Study type: Interventional

Tinnitus (i.e., ringing in the ears) is currently the most prevalent disability among Veterans. A range of clinical interventions has been created to systematically address the range of issues caused by tinnitus. While numerous interventions purport to promote coping strategies for tinnitus-related problems, few studies directly target and measure coping outcomes. The present pilot study proposes a comparison of coping outcomes after 3 psycho-educational groups: a cognitive-behavioral therapy (CBT) intervention, a Coping Effectiveness Training (CET) intervention, or an Acceptance and Commitment Therapy intervention among Veterans with tinnitus. These groups will be compared to a usual care group among Veterans and civilians with tinnitus. The proposed study will be the first application of CET to tinnitus. The primary goals of this study are to develop a CET protocol for tinnitus and to evaluate the effectiveness of CBT, CET, and ACT interventions to a usual care group. The long-term goal of this study is to improve the quality of life among individuals with tinnitus.

NCT ID: NCT02290015 Completed - Tinnitus Clinical Trials

Acupuncture as a Treatment for Tinnitus

Start date: August 2010
Phase: N/A
Study type: Interventional

This trial was a randomized, single-blinded, sham-controlled study, in which the patients were blinded to treatment assignment. First, all candidates underwent audiological testing of hearing thresholds, tympanometry and stapedius reflex tests. The patients who were selected for the study were interviewed to assess and evaluate their condition and then underwent a detailed physical examination that included a complete otorhinolaryngologic examination and a complete blood test. Then, the subjects were randomized to undergo true or sham ACP. Seven days before (baseline) and seven days after twelve acupuncture (ACP) sessions (up to six weeks), which were performed twice a week, all participants underwent 99mTc-ECD SPECT scanning and completed the Portuguese version of the Tinnitus Handicap Inventory (THI), the Visual Analogue Scale (VAS), Hamilton Anxiety Scale (HAS) and the Beck Depression Inventory (BDI). The purpose of this study was to integrate the neuroscience research findings with the clinical research on tinnitus. Thus, a randomized, single-blinded, placebo-controlled trial was implemented to investigate the effect of ACP as a treatment for tinnitus using ethylcysteine dimer single-photon emission computer tomography (99mTc-ECD SPECT).

NCT ID: NCT02269839 Completed - Tinnitus Clinical Trials

A Feasibility Study Assessing the Effectiveness of rTMS in Tinnitus

Start date: September 2014
Phase: N/A
Study type: Interventional

Tinnitus is a common problem which can have a severe impact on quality of life and for which there is no truly successful treatment available. Repetitive transcranial magnetic stimulation (rTMS) is a method of stimulating the brain through the application of a magnetic field in a series of rapid pulses and may be a valuable treatment for patients with tinnitus. The overall aim of this research is to see if patients with tinnitus benefit from treatment with rTMS, and in particular whether one type (continuous theta burst) is more effective than other variations of rTMS. Prior to developing a definitive study to address this area a feasibility study needs to be performed. The proposed feasibility study aims to determine outcomes necessary to enable development of a definitive study in the future. 40 patients suffering with idiopathic tinnitus will be randomised into 2 groups, a control group receiving a sham treatment, and an active treatment group receiving theta-burst rTMS on 5 consecutive days.

NCT ID: NCT02266160 Completed - Tinnitus Clinical Trials

Treating Tinnitus Using Eutectic Mixture of Local Anesthetics (EMLA) 5% Cream

Start date: November 2014
Phase: Phase 4
Study type: Interventional

The investigators like to learn whether EMLA cream 5% helps tinnitus patients. so far it is known that lidocaine I.V do helps tinnitus but until now it is not clear if topical anaesthetics (e.g EMLA cream) helps tinnitus. The investigators are going to compare 4 days of treatment of EMLA 5% cream Versus (VS.) cetomacrogol cream (water- based lotion cream) in treating tinnitus patients.

NCT ID: NCT02199106 Completed - Chronic Tinnitus Clinical Trials

Effectiveness of Neuronavigated Continuous Theta Burst Stimulation of the Left Heschl's Gyrus in Chronic Tinnitus

Start date: January 2009
Phase: N/A
Study type: Interventional

Neuronavigated continuous theta burst stimulation of the left Heschl's gyrus is used to modulate auditory cortex activity and plasticity contributing to the perception and distress of chronic tinnitus.

NCT ID: NCT02191592 Completed - Tinnitus Clinical Trials

EMA-Defined Tinnitus Subgroups

Start date: July 2014
Phase: N/A
Study type: Observational [Patient Registry]

The purpose of this research study is to test a new way of measuring the severity of tinnitus using a tool called Ecological Momentary Assessment (EMA) of Tinnitus. We will compare the relationship with this tool with another widely used questionnaire. Previous studies we have done suggest there are different patterns of tinnitus bother; we plan to explore how often these patterns occur, and how many patterns of tinnitus bother there are. And lastly we want to test how reliable this type of testing is for measuring the amount of bother people experience from their tinnitus. Hypothesis 1: We will be able to identify 6 or more distinctive patterns of tinnitus. Hypothesis 2: EMA will provide a reliable method for more accurately capturing the amount of bother individuals have from tinnitus.