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Tinnitus clinical trials

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NCT ID: NCT01962558 Completed - Tinnitus Clinical Trials

Vagus Nerve Stimulation (VNS) Paired With Tones for Tinnitus

Start date: February 2014
Phase: N/A
Study type: Interventional

Assess the safety and efficacy of VNS paired with tones for tinnitus using a randomized, controlled, parallel study design.

NCT ID: NCT01944501 Completed - Hearing Loss Clinical Trials

Neuromodulation Techniques in the Treatment of Chronic Tinnitus With Hearing Loss

Start date: March 2012
Phase: N/A
Study type: Interventional

This study aimed at trying transcranial magnetic stimulation and transcranial direct current stimulation as potential treatments to decrease tinnitus in patients with significant hearing loss.

NCT ID: NCT01934010 Completed - Tinnitus Clinical Trials

AM-101 in the Treatment of Post-Acute Tinnitus 1

AMPACT1
Start date: June 2014
Phase: Phase 3
Study type: Interventional

The purpose of this research study is to test the safety and local tolerance of repeated treatment cycles of AM-101.

NCT ID: NCT01929837 Completed - Tinnitus Clinical Trials

Tinnitus rTMS 2013

Start date: September 2013
Phase: N/A
Study type: Interventional

Tinnitus is the perception of sound in the absence of corresponding external sound. Tinnitus affects approximately 10-15 % of the population. The prevalence increases with age and it is estimated that more than 20 % of the older people have tinnitus. Approximately 10-15 % of tinnitus patients have clinically relevant, disabling tinnitus causing for example anxiety, depression and sleep disturbances. The treatment of chronic tinnitus is difficult and most therapies focus on alleviating the condition rather than treating the cause. Pathophysiology of tinnitus still remains incompletely understood. Functional brain imaging data in tinnitus patients and animal models suggest that tinnitus is associated with increased neuronal activity, increased synchronicity, and functional reorganization within the auditory cortex either uni- or bilaterally, but there are also functional alterations in brain areas outside the auditory system. Transcranial magnetic stimulation (TMS) is a neuromodulation technique based on the principle of electromagnetic induction of an electric field in the brain by means of magnetic pulses given to the scalp. TMS is a non-invasive, painless, and safe method for modulation of cortical activity. TMS pulses given at low frequencies (≤ 1 Hz) have been shown to decrease cortical excitability both in experimental settings and humans, which forms the basis for using low frequency rTMS to treat chronic tinnitus patients, in whom hyperactivity of the auditory cortex has been observed in functional brain imaging studies

NCT ID: NCT01927991 Completed - Tinnitus Clinical Trials

Internet-based Self-help for Tinnitus: The Role of Support

Start date: September 2012
Phase: N/A
Study type: Interventional

Internet-based cognitive behavioural self-help (iCBT) has become increasingly popular to provide psychotherapy. For several psychological and psychosomatic disorders, treatment efficacy was shown. Previously, iCBT has also been applied to patients suffering from tinnitus and results show significant and long-term stable improvements in tinnitus distress. However, the role of therapeutic support in iCBT has not been thoroughly investigated. Previous results suggest that iCBT without therapeutic support is less effective and leads to higher dropout rates than therapist-guided iCBT. The aim of the randomized controlled trial is thus to investigate the role of therapeutic support in an iCBT for tinnitus sufferers.

NCT ID: NCT01907022 Completed - Chronic Tinnitus Clinical Trials

Combined rTMS and Relaxation in Chronic Tinnitus

RELAX
Start date: July 2013
Phase: N/A
Study type: Interventional

Repetitive Transcranial Magnetic Stimulation in combination with relaxation therapy is used to modulate the neural pathways contributing to the perception and distress of phantom sounds.

NCT ID: NCT01857661 Completed - Hearing Loss Clinical Trials

The Influence of the Sound Generator Combined With Conventional Amplification for Tinnitus Control: Blind Randomized Clinical Trial

Start date: September 2012
Phase: N/A
Study type: Interventional

The University of Sao Paulo Department of Otorhinolaryngology developed prototypes for a digital new hearing aid with an integrated sound generator. These prototypes assist both hearing rehabilitation (about 10% of the population) and tinnitus sufferers (about 17% of the population). Currently, the Brazilian Public Heath Care does not have any such hearing aids. So, the development of devices for the hearing rehabilitation as well as the treatment of tinnitus represents an advance in the implementation of Public Policies in Brazil. The aim of this study is to compare the efficacy of the hearing aid with an integrated sound generator and amplification alone for tinnitus control in patients with tinnitus associated hearing loss.

NCT ID: NCT01855425 Completed - Otosclerosis Clinical Trials

Cone Beam CT for Diagnosis of Select Otorhinolaryngology (ENT) Indications at Lower Dose

CBCT-ENT
Start date: September 21, 2012
Phase: N/A
Study type: Interventional

The study objective is to compare the CBCT images generated by the CS 9300 to those generated by conventional CT.

NCT ID: NCT01845155 Completed - Tinnitus Clinical Trials

Neuro-Music-Therapy for Patients With Chronic Tinnitus - a Controlled Clinical Trial

Start date: March 2006
Phase: N/A
Study type: Interventional

BACKGROUND: Tinnitus is a nonspecific symptom of hearing disorder characterized by the sensation of buzzing, ringing, clicking, pulsations, and other noises in the ear. Despite a variety of treatments, many patients with chronic tinnitus ask for more active ways in coping with their tinnitus. Gold standard treatment in chronic tinnitus is a comprehensive directive counseling explaining the underlying mechanisms leading to the tinnitus percept. Therefore a neuro-music therapeutic treatment based on a bio-psycho-social framework was developed and compared to a counselling-only control group. INTERVENTION: two standardized protocols for tinnitus therapy were defined ("neuro-music therapy" vs. "counselling")

NCT ID: NCT01837368 Completed - Tinnitus Clinical Trials

Research Project About Psychological Strain, Quality of Life and Emotional Awareness in Patients With Tinnitus

Start date: December 2012
Phase: N/A
Study type: Observational

Validation of PRISM (Pictorial Representation of Illness and Self Measure) as a assessment of quality of life and suffering in patients with tinnitus. Association between experiencing, verbalizing and regulating emotions and perceived tinnitus. Correlation analysis are used to search for connections between the subjective behavioral outcomes mentioned above and the objective EEG-patterns.