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Tinnitus clinical trials

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NCT ID: NCT05374421 Terminated - Tinnitus Clinical Trials

Efficacy of the Erchonia Corporation THL™ for Providing Relief of Tinnitus Symptoms

Start date: May 10, 2022
Phase: N/A
Study type: Interventional

The purpose of this clinical study is to determine the effectiveness of the Erchonia® THL™, manufactured by Erchonia Corporation (the Company), for prescription home use in providing relief of tinnitus symptoms when used by individuals in their own homes.

NCT ID: NCT05091060 Terminated - Tinnitus Clinical Trials

Effect of the Erchonia® HLS™ for the Relief of Tinnitus Symptoms

Start date: June 10, 2021
Phase: N/A
Study type: Interventional

This study is to see if applying red low-level laser light can help to reduce tinnitus symptoms

NCT ID: NCT04226456 Terminated - Tinnitus Clinical Trials

Intratympanic Administration of N-acetylcysteine for Protection of Cisplatin-induced Ototoxicity

Start date: July 10, 2021
Phase: Phase 4
Study type: Interventional

The purpose of this study is to assess the efficacity of N-acetylcystein against Cisplatin-induced ototoxicity.

NCT ID: NCT04210310 Terminated - Tinnitus Clinical Trials

High Dose Oxytocin Nasal Spray for Treatment of Tinnitus

Start date: January 15, 2020
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the effects of high-dose intranasal oxytocin for treating tinnitus. The hypothesis is that high dose intranasal oxytocin can significantly reduce tinnitus severity and disability.

NCT ID: NCT03957122 Terminated - Tinnitus Clinical Trials

Individualized Treatment of Patients With Chronic Tinnitus With Repetitive Transcranial Magnetic Stimulation

indiTMS
Start date: May 1, 2019
Phase: N/A
Study type: Interventional

In the first visit a magnetic resonance imaging measurement will be done for the use of a neuronavigation System with the aim to control for stable coil position over the course of the trial. EEG positions CP5/CP6 will be used for positioning the coil. Two test sessions will examine the temporary reductions in tinnitus loudness after 1Hz, 10Hz, 20Hz and 0.1Hz rTMS as control condition over left and right temporo-parietal junction accompanied by electroencephalography. For the two-week treatment three arms will be evaluated: standard treatment (1Hz left-sided) in the groups with and without temporary reductions in test sessions and the best protocol as elicited in test sessions.

NCT ID: NCT03699826 Terminated - Tinnitus Clinical Trials

Experimental Tinnitus Treatment With Transcranial Magnetic Stimulation

Start date: December 10, 2018
Phase: N/A
Study type: Interventional

There are numerous conditions that may benefit from TMS but they lack definitive data from clinical trials with sufficient scientific rigor, which includes large, multi-site, randomized sham-controlled trials. This is the status for a variety of psychiatric and neurological disorders such as tinnitus, central pain, movement disorders, stroke rehabilitation, obsessive compulsive disorders, anxiety, schizophrenia, and addiction. In certain instances there may be sufficient evidence supporting the treatment efficacy of TMS that it is reasonable to offer TMS as an off-label treatment, a term for clinical treatments that have not received FDA approval but may nonetheless be helpful for patients. In other cases there is such a paucity of clinical trial data that the use of therapeutic TMS is less appropriate as a clinical treatment that the patient is charged for out of pocket and may cost several thousand dollars, but is better suited for clinically-oriented research. This has the added benefit of potentially helping the patient and providing investigators with additional information from which to inform future clinical trials. In this study the investigators propose to use TMS to treat tinnitus, for which few other treatments currently exist. Tinnitus affects approximately 1% of the population and can be debilitating for patients. Recent studies have shown some promise in reducing symptoms through neuromodulation, but results are variable and more research is needed to improve treatment protocols. The investigators plan to contribute to this body of research by taking an evidence-based approach to test whether TMS is effective at reducing symptoms of tinnitus. Each subject's MRI will be used to perform neuronavigated TMS stimulations while documenting changes in symptom severity with self-report questionnaires and symptom severity scales. If it is determined that a stimulation protocol is effective, 1-2 weeks of daily treatments will be scheduled as part of that subject's personalized treatment plan.

NCT ID: NCT03309696 Terminated - Tinnitus Clinical Trials

Regulating Homeostatic Plasticity and the Physiological Response to rTMS

Start date: November 16, 2017
Phase: N/A
Study type: Interventional

This device-study includes a pilot, physiological investigation of normal human subjects. The aim is to determine how existing non-invasive neuromodulation devices affect brain circuitry as measured by EEG recording. Currently, the application of non-invasive neuromodulation is rarely guided by detailed knowledge of how neural activity is altered in the brain circuits that are targeted for intervention. This gap in knowledge is problematic for interpreting response variability, which is common. To address this gap, the current proposal aims to combine two forms of neuromodulation sequentially, transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS), to regulate homeostatic plasticity prior to rTMS delivery at different frequencies of rTMS. Homeostatic plasticity, the initial activation state of a targeted circuit, is a key determinant of whether rTMS induces long term potentiation (LTP) or long term depression (LTD) Yet, homeostatic plasticity is rarely measured or controlled in rTMS studies. We aim to control homeostatic plasticity by preconditioning the targeted circuits with tDCS prior to rTMS delivery. The protocol included an exploratory aim to examine physiological changes in patients with tinnitus but this aim was not part of the pilot physiological investigation and it could not be completed due to funding limitations.

NCT ID: NCT03026829 Terminated - Clinical trials for Tinnitus, Hearing Loss, Cochlear Implant Users

Sound Therapy for Tinnitus Relief in Cochlear Implant Users

Start date: October 3, 2017
Phase: N/A
Study type: Interventional

The aim of this exploratory study is to evaluate the use and effectiveness of sound therapy for tinnitus relief in cochlear implant users with tinnitus. The sound therapy is a combination of tinnitus counselling and sound enrichment with the Cochlear Active Relief from Tinnitus (CART) firmware.

NCT ID: NCT02853812 Terminated - Tinnitus Clinical Trials

Tinnitus Related Cerebral Activities

ACCELA
Start date: February 5, 2013
Phase: N/A
Study type: Interventional

The proposed research is to identify the brain areas activated or deactivated by tinnitus in humans. The identification of these areas is expected to be able to treat tinnitus refractory to traditional therapies by methods of brain stimulation. Furthermore, this technique would be very useful to verify the effectiveness of any treatment to relieve tinnitus. The brain activation measured during fMRI will be performed in a position of rest, after inhibition of tinnitus, and after application of a sound that does not inhibit tinnitus. This comparison will identify specific brain areas activated or deactivated by tinnitus.

NCT ID: NCT02734576 Terminated - Tinnitus Clinical Trials

Venous Sinus Stenting To Treat Intractable Pulsatile Tinnitus Caused By Venous Sinus Stenosis

Start date: January 24, 2017
Phase: N/A
Study type: Interventional

There have been few published studies that examine the efficacy and safety of endovascular treatments on patients with pulsatile tinnitus with venous stenosis. Despite the limited experience with venous sinus stenting to treat pulsatile tinnitus, preliminary results show that venous sinus stenting could represent a viable alternative for refractory pulsatile tinnitus patients with venous sinus stenosis. The purpose of this study is to evaluate the safety and efficacy of this procedure in a controlled fashion, using strict inclusion and exclusion criteria, and long-term clinical and imaging follow-up. The investigators hope to provide robust data regarding the safety and efficacy of venous sinus stenting for patients with pulsatile tinnitus.