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Tinnitus clinical trials

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NCT ID: NCT02772536 Recruiting - Tinnitus Clinical Trials

A Clinical Trial Investigating Effect of Tinted Light on Perception of Tinnitus

Start date: March 2015
Phase: N/A
Study type: Interventional

Background An earlier pilot study provided evidence that about 40% of tinnitus sufferers reported that viewing particular tints of light appeared to result in some improvement of their tinnitus. This ameliorative effect appeared to be primarily acute and only reported to occur whilst viewing the tint. Individual patients would choose differing tints with some identifying more than one tint that affected their tinnitus. Aim of the Study In this current basic science study, the aim is to provide preliminary data to return estimates of the efficacy of using tinted light to ameliorate tinnitus. After identification of responders during screening, responders are invited to attend three further trial sessions, where their tinnitus is assessed in response to three luminance conditions: Low Ambient Light; Tint of Light affecting Tinnitus; White Light. The response to low ambient light serves as a control to compare the effect of tinted light against and the response to white light serves as an 'active' stimulus comparator. These results will then establish whether tinted light provides patients with a useful improvement in their tinnitus compared with measures of their baseline tinnitus obtained in the dark and against a standardised white light stimulus. They will also inform further development of the technique as a potential treatment for tinnitus in responsive patients. Over the three sessions, the averaged responses given by the patient under each stimulus condition will be analysed to provide a measure of efficacy.

NCT ID: NCT02737670 Recruiting - Clinical trials for Tinnitus, Subjective

Sulodexide Efficacy in Chronic Idiopathic Subjective Tinnitus

SECIST
Start date: August 2015
Phase: Phase 2
Study type: Interventional

The objective of this prospective randomized and double blind controlled study is to evaluate the efficacy and safety of Sulodexide (25 mg) in the treatment of chronic idiopathic subjective tinnitus.

NCT ID: NCT02734576 Recruiting - Tinnitus Clinical Trials

Venous Sinus Stenting To Treat Intractable Pulsatile Tinnitus Caused By Venous Sinus Stenosis

Start date: May 2016
Phase: Phase 1
Study type: Interventional

There have been few published studies that examine the efficacy and safety of endovascular treatments on patients with pulsatile tinnitus with venous stenosis. Despite the limited experience with venous sinus stenting to treat pulsatile tinnitus, preliminary results show that venous sinus stenting could represent a viable alternative for refractory pulsatile tinnitus patients with venous sinus stenosis. The purpose of our study is to evaluate the safety and efficacy of this procedure in a controlled fashion, using strict inclusion and exclusion criteria, and long-term clinical and imaging follow-up. The investigators hope to provide robust data regarding the safety and efficacy of venous sinus stenting for patients with pulsatile tinnitus.

NCT ID: NCT02684890 Not yet recruiting - Tinnitus Clinical Trials

Detection of Emotions in a Spoken Language Among Tinnitus Patients

EMSLT
Start date: March 2016
Phase: N/A
Study type: Observational

Tinnitus may affect the ability of patients to detect emotions in spoken language. This study will compare this ability between tinnitus patients and non-tinnitus patients.

NCT ID: NCT02665975 Not yet recruiting - Tinnitus Clinical Trials

Internet-based Versus Face-to-face Clinical Care for Tinnitus

Start date: October 2016
Phase: N/A
Study type: Interventional

The purpose of this study is to compare the effectiveness of a CBT-based internet intervention with face to face standard clinical care for adults with tinnitus in the United Kingdom.

NCT ID: NCT02653547 Recruiting - Chronic Tinnitus Clinical Trials

Influence of Treatment Duration and Stimulation Frequency on rTMS in Chronic Tinnitus

Start date: January 2016
Phase: N/A
Study type: Interventional

Patients receive two weeks of treatment (prefrontal high-frequency and bilateral low-frequency rTMS vs. prefrontal high-frequency and bilateral high-frequency rTMS). After two weeks of treatment they can decide if they want to quit the treatment or if they want to proceed with the treatment for another two weeks.

NCT ID: NCT02648542 Completed - Tinnitus Clinical Trials

The Effects of Compensatory Auditory Stimulation and Transcranial Direct Current Stimulation on Tinnitus Perception

Start date: March 2013
Phase: N/A
Study type: Interventional

This study evaluates the ability of compensatory auditory stimulation (CAS) and transcranial direct current stimulation (tDCS) to help alleviate tinnitus. Subjects will receive CAS, tDCS, and the combination of the two to assess the effectiveness of the treatment.

NCT ID: NCT02632058 Active, not recruiting - Tinnitus Clinical Trials

Efficacy of Treatment for Tinnitus

Start date: August 2015
Phase: N/A
Study type: Observational

Tinnitus is the acoustic perception of sound without any physical source. It is estimated that 15-21% of adults develop a Tinnitus, which can cause serious distress and debilitation in all aspects of daily life of the affected. There is currently no evidence for a successful treatment of tinnitus. While one treatment approach involves sound-based therapies, e.g. tinnitus retraining therapy. The treatment aspect in our setting involved cognitive behavioural therapy.

NCT ID: NCT02630589 Not yet recruiting - Tinnitus Clinical Trials

Implantation of an Auditory Brainstem Implant for the Treatment of Incapacitating Unilateral Tinnitus

Start date: January 2016
Phase: N/A
Study type: Interventional

Tinnitus is the perception of sound or noise in the absence of an external physical source. It is a highly prevalent condition and for a high percentage of patients, there is no satisfying treatment modality. For some people, tinnitus has a very severe impact on quality of life, leading to incapacity for work and sometimes even suicidality. The auditory brainstem implant (ABI) is an implant indicated for the restoration of hearing in patients with an hypo-, or aplasia of the cochlear nerve or with dysfunction of the nerve caused by tumor growth in neurofibromatosis type II. It has been shown that the standard intended effect of an ABI has reduction of tinnitus as a welcome side effect in about 66% of the cases. This is in analogy with the promising effect of a cochlear implant (CI) as a treatment for patients with unilateral tinnitus. In this study, the effect of an ABI on severely invalidating, unilateral, intractable tinnitus will be investigated. The ABI may have an advantage over the CI as tinnitus treatment, because CI-implantation leads to destruction of inner ear structures, leading to profound deafness, while an ABI is presumed to not damage anatomical structures. This is the first study to implant an ABI for the primary aim of tinnitus reduction in an intervention pilot study. In total 10 patients with unilateral, intractable tinnitus and severe hearing loss in the ipsilateral ear, will be implanted with the ABI.

NCT ID: NCT02617953 Enrolling by invitation - Tinnitus Clinical Trials

Objective Diagnosis Method and Efficacy of Repetitive Transcranial Magnetic Stimulation as a Treatment for Tinnitus

Start date: September 2015
Phase: N/A
Study type: Interventional

Investigation of objective tinnitus diagnosis method through measurement of continuous resting EEG, auditory ERP before and after Repetitive Transcranial Magnetic Stimulation (rTMS) treatment of tinnitus.