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Survival clinical trials

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NCT ID: NCT04321265 Recruiting - COVID-19 Clinical Trials

Outcomes and Prognostic Factors in COVID-19

COVIP
Start date: March 19, 2020
Phase:
Study type: Observational

The primary aim is to study the short-term outcome of elderly ICU patients (≥ 70 years) suffering from COVID-19 using a multicenter and multi-national approach. The secondary aim is to investigate the properties of a simple frailty scale in this cohort, and in particular if this is an instrument that can be used for outcome prediction in this group. In addition, various other parameters of potential relevance for older critically ill patients will be studied.

NCT ID: NCT04280822 Recruiting - Surgery Clinical Trials

Neo-adjuvant Immunochemotheray Versus Neo-adjuvant Chemotherapy for Resectable Esophageal Carcinoma

Start date: April 21, 2020
Phase: Phase 3
Study type: Interventional

The effect of neo-adjuvant immunochemotherapy on survival of patients with thoracic esophageal squamous cell carcinomas remains unknown. One of our objectives is to evaluate whether the neo-adjuvant immunochemotherapy Toripalimab (JS001) with cisplatin and paclitaxel followed by right thoracic approach esophagectomy with total 2-field lymph node dissection improves the overall survival of thoracic esophageal cancer patients versus neo-adjuvant chemotherapy.

NCT ID: NCT04151394 Completed - Clinical trials for Surgery--Complications

Side-to-side Duodenojejunostomy After Distal Duodenal Resection (DUORESECT)

DUORESECT
Start date: January 31, 2019
Phase:
Study type: Observational [Patient Registry]

Lower partial duodenectomy could be indicated in case of injury, wide neck diverticulum, tumor invasion by other tumors such as retroperitoneal sarcoma and primary tumor of 3rd and 4th portion of the duodenum. Reconstruction after resection is usually performed by a end-to-end or end-to-side anastomosis. The investigators analyze the short and long-term results of a case series with resection for various lesions in the third and fourth duodenal portions and reconstruction of the intestinal transit through side-to-side duodenojejunostomy

NCT ID: NCT04037982 Not yet recruiting - Death Clinical Trials

RCT Study on Safety of LPD and OPD in the Treatment of Periampullary Tumors

Start date: August 2019
Phase: N/A
Study type: Interventional

Pancreaticoduodenectomy (PD) is considered one of the most complex and dangerous procedures in general surgery. This procedure is the preferred surgical procedure for treating tumors around the ampulla. Traditional open pancreaticoduodenectomy (OPD) has brought great surgical trauma to patients while treating diseases. In 1994, Gagner et al first reported laparoscopic pancreaticoduodenectomy (LPD). With the development of laparoscopic techniques, the updating of devices, and the continuous accumulation of laparoscopic gastrointestinal surgery experience, the results of retrospective studies published show that there is no significant difference in safety between LPD and OPD. However, the results of the recently published RCT study show that the mortality associated with LPD complications is five times greater than that of OPD. At present, the security of LPD has been controversial. Therefore we conducted a prospective randomized controlled trial with a primary outcome of perioperative complications, providing evidence-based results for the safe and effective clinical development of LPD.

NCT ID: NCT03977389 Completed - Survival Clinical Trials

Total Wrist Denervation: Survival Study and Functional Outcomes

DTDPESERF
Start date: March 20, 2018
Phase:
Study type: Observational

The purpose of the study is to evaluate the long-term effectiveness of total wrist denervation on pain by assessing the surgery survival. The residual functional wrist's quality and the patients' satisfaction will also be evaluate.

NCT ID: NCT03939221 Completed - Survival Clinical Trials

Measure the Meridian Energy Change of Terminal Hospice Patient Via Meridian Energy Analysis Device

Start date: February 18, 2019
Phase: N/A
Study type: Interventional

In the hospice ward, there are lots of suffered hospital patients with multiple physical discomfort related to terminal disease. Investigators want to use an objective measure instrument to monitor the effects of complementary and alternative medicine and clinical symptoms. First, investigators use the Meridian Energy Analysis Device (MEAD) to measure the bilateral 12 Yuan points (primary points) of terminal hospice patients. It provides the prediction value between terminal disease and the change of different meridian energy. Besides, the meridian energy value maybe predict the survival period. Then, the intervention of complementary and alternative medicine can also monitor via MEAD.

NCT ID: NCT03920033 Recruiting - Prostate Cancer Clinical Trials

Salvage Hypofractionated Accelerated Versus Standard Radiotherapy for Biochemical Failure After Prostatectomy

SHARE
Start date: May 1, 2019
Phase: N/A
Study type: Interventional

Patients with a biochemical recurrence after radical prostatectomy for moderate- or high- risk prostate cancer are randomly assigned to hypofractionated, accelerated high dose radiation therapy group (65 Gy, 26 fractions) and a control group of standard treatment group (66 Gy, 33 fractions). The criteria for stratification at randomization include 1) risk groups, 2) androgen deprivation therapy, and 3) PSA before salvage radiation therapy, which affect biochemical recurrence. It is expected that hypofractionated, accelerated high dose radiation therapy will have a superiority in terms of biochemical control to conventional radiation therapy, and the present study would like to confirm this. In addition, we aimed to evaluate and compare the toxicity and quality of life index of two radiation therapy regimens.

NCT ID: NCT03739944 Recruiting - Quality of Life Clinical Trials

Different Surgical Approaches in Patients of Early-stage Cervical Cancer

Start date: November 23, 2018
Phase: Phase 3
Study type: Interventional

This multi-center, randomized controlled study aims to compare the survival outcomes (including overall survival, progression-free survival and disease-free survival between Chinese uterine cervical patients receiving different surgical routes (laparotomy and laparoscopy) for radical hysterectomy or trachelectomy, which is the primary study objective. All patients with uterine cervical cancer of FIGO stage IA1 (with lymphovascular space invasion), IA2 and IB1 will be included and randomized into two groups: laparotomy and laparoscopy groups for radical hysterectomy or trachelectomy. Secondary study objectives include: patterns of recurrence, treatment-associated morbidity (6 months from surgery), cost-effectiveness, pelvic floor function, and quality of life.

NCT ID: NCT03738969 Recruiting - Mortality Clinical Trials

Longitudinal Study of Different Surgical Approaches in Chinese Patients of Uterine Cervical Cancer

Start date: November 10, 2018
Phase:
Study type: Observational

This multi-center longitudinal study aims to compare the survival outcomes (including overall survival, progression-free survival and disease-free survival between uterine cervical patients receiving different surgical routes (vaginal, laparotomy and laparoscopy), which is the primary study objective. All clinical and pathological data would be retracted from case reviews, and all survival data would be reached by clinic, telephone and mail follow-up. This study also would analyze the impact on survival outcomes of other factors, including nerve-sparing techniques, neoadjuvant chemotherapy, neoadjuvant radiotherapy and infection of human papillomavirus. The predictive effects of different following protocol and imaging plans will be also compared. Last, the influences of surgical routes on the fertility outcomes (pregnancy and its complications) and the ovarian reserve are important secondary study objectives.

NCT ID: NCT03642041 Completed - Quality of Life Clinical Trials

Study of Smoking Trajectory in Newly Diagnosis Lung Cancer Patients

Start date: May 24, 2014
Phase:
Study type: Observational

1. Understanding the smoking change patterns among the newly diagnosis lung cancer patients after cancer diagnosis. 2. Explore the related factors of the smoking change patterns. 3. The type of smoking trajectory impact on survival and quality of life.