Prevalence of Trephined Syndrome After Decompressive Craniectomy

Stroke Clinical Trial

— TS  

Official title:

A Prospective Observational Study on Risk Factors of Developing and Prevalence of Trephined Syndrome in Patients After Hemispheric Decompressive Craniectomy and Effect of Cranioplasty on Functional and Cognitive Recovery

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT03186157
• Other study ID #: CER 11-234 (NAC 11-086)
• Status: Terminated
• Start date: January 16, 2012
• Est. completion date: March 31, 2017

Study information

• Verified date: November 2020
• Source: University Hospital, Geneva
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Decompressive craniectomy is frequently used to treat increased intracranial pressure or an intracranial mass effect. Trephined Syndrome describes a neurological deterioration, which is attributed to a large craniectomy. The symptomatology is varied but includes headache, aggravation of a hemisyndrome or cognitive disorders, often has an orthostatic component and improves or disappears with cranioplasty. The incidence of Trephined Syndrome has been reported between 7% and 26%. However, it might be underestimated if the course of cognitive functions before and after cranioplasty were insufficiently documented.

Description:

Decompressive craniectomy is a neurosurgical procedure that is used frequently for mass and/or intracranial hypertension. The Trephined Syndrome (or Sinking Skin Flap Syndrome) is a neurological deterioration which follows craniectomy and which is attributed to a large bone flap size. The symptomatology is varied but includes headache, aggravation of a hemisyndrome or cognitive disorders, often has an orthostatic component and improves or disappears with cranioplasty.

The pathophysiology of the Trephined Syndrome is not clearly understood. The hypothesis is that the contents of the skull, which is no longer isolated by the bone, is then subjected to atmospheric pressure, which would lead to changes in the blood flow, but also abnormalities in the circulation of the cerebrospinal fluid and even cell metabolism.

The precise incidence of the Trephined Syndrome is poorly known but is described to be 7% up to 26%. It is much likely underestimated since it concerns patients with preexisting neurological symptoms and often multiple comorbidities. Furthermore its presentation varies in a way, that in certain patients the Trephined Syndrome manifests itself by neurological aggravation, while in other patients it is only the absence of evolution in rehabilitation, followed then by improvement after cranioplasty, which makes it possible to retain this diagnosis a posteriori.

The diagnosis is also difficult since it is a clinical diagnosis of exclusion. The cerebral imaging that shows contralateral herniation than the craniectomy is pathognomonic, but is not a gold standard for diagnosis, since the symptomatology can occur before this stage of radiological presentation.

It is, of course, necessary to wait until the regression of the edema makes it possible to restore the flap without risk of inducing a new lesion but the ideal moment of the cranioplasty is unknown. The risk of infectious disease may be increased during "early" remission, on the other hand the risk of developing the Trephined Syndrome or other complications increases during "late" cranioplasty.

Currently at our university teaching hospital the cranioplasty is planned after a delay of 3 months, because of a fear of infectious complications in case of earlier remission. However, in neuro-rehabilitation, a shortening of this delay is desirable, especially when the patient can mobilize and/or be discharged home (helmets are often not well supported) or when a radiological and clinical Trephined Syndrome occurs. Indeed, the solution of staying in bed awaiting the 3 month delay is not ideal both from the point of view of rehabilitation (very limited therapies in the prone position, risk of the appearance of complications of the decubitus), comfort of the patient and eventual non reversible neurological damage due to the Trephined Syndrome.

This observational prospective study focus on patients with cerebral damage who underwent decompressive craniectomy due to mainly traumatic brain injury and ischemic stroke with malignant edema or hemorrhagic stroke and other causes of intracranial mass effect). The study comprises a fragile population, but it is also a population that is affected by a possible modification of the delay to cranioplasty.

The presence and type of symptomatology attributable to the Trephined Syndrome, its duration, severity and its modification after cranioplasty will be recorded. The delay for cranioplasty and any complications (such as hematoma or infectious complications) of the latter will be noted. The study aims to provide valuable information on how to to better plan the care for patients who undergoes decompressive craniectomy and to determine the optimal delay for the cranioplasty.

METHODS:

This is a prospective, observational study. It will include a neurological and cognitive examination upon arrival in the neuro-rehabilitation department. It is expected that the patient will remain stable or improve during the stay in neuro-rehabilitation. In case of neurological aggravation, if a Trephined Syndrome is suspected (other causes must be well dismissed such as recurrence of stroke, haemorrhage, infection, hydrocephalus, electrolytic or metabolic disorder, toxic and metabolic abnormalities, epileptic crisis etc) a new neurologic evaluation will specify the type of deficit. The examination will take place in the morning and evening after a day of therapies to eventually observe the neurological aggravation due to orthostatism. In the event of a evident worsening due to orthostatism, as usual, a bed rest awaiting cranioplasty will be offered to the patient. In all patients (improved compared to admission, stable or worse) an examination at 7-10 days before the cranioplasty will be performed and then repeated 1-4 days before and then 1-4 days after the cranioplasty. The delay of cranioplasty in relation to the date of craniectomy, the date (if known) when a cranioplasty was considered possible in terms of radiological and clinical evaluation and the date of start of the Trephined Syndrome will be recorded. Complications related to cranioplasty will be noted. At the patient's discharge from neuro-rehabilitation department a final examination will be performed. The mentioned evaluations will be carried out by the medical residents in charge of the patient under the supervision and assistance of the study investigators.

The patients will be classified as having the Trephined Syndrome if s/he: a) shows a neurological aggravation with no other cause (see above) with a typical imaging; (B) a neurological aggravation with no other cause (see above) but aggravated to orthostatism and / or at least partially reversible shortly following cranioplasty (no longer than 4 days after) or c) if there is a rapid neurological improvement after cranioplasty (no longer than 4 days after). The waiting period until the cranioplasty will be recorded for each case. The possible complications of the cranioplasty (in particular hematoma and infectious) will be recorded.

There is no randomization since this is an observational study.

Participation in the study is offered to all patients with decompressive craniectomy upon arrival in neuro-rehabilitation department. The duration of follow-up will be that of stay in neuro-rehabilitation (usually for this type of population at least 4-6 months). The study will cover 5 years in view of the low number of patients with craniectomy. The patient can of course leave the study at any time if he wishes.

Collected Data will include age, sex, baseline diagnosis, neurological assessment at the various stages (admission at neuro-rehabilitation, at the time of a possible neurological deterioration, 7-10 days then 1-4 days before, 1-4 Days after cranioplasty, at the time of final discharge from the neuro-rehabilitation department), the results of the neurological imaging, the delay between craniectomy and cranioplasty, delay between the theoretic possibility of cranioplasty (if known) and the actual cranioplasty, complications related to cranioplasty and functional and cognitive outcome.

This study does not include administration of medicinal products or changes in the usual management of patients in neurosurgery and neuro-rehabilitation departments. In the case of a recognized Trephined Syndrome, cranioplasty is always promptly requested. Unfortunately the waiting periods remain, even in this case sometimes long, due to the availability of neurosurgeons. The study could provide objective data to improve the management of these patients.

Criteria to be evaluated:

Clinical history data: Orthostatic headache, motor function deterioration or other.

Local examination of the craniectomy site: presence of edema, fluid collection, sinking skin flap, size of the bone flap.

Neurological examination with in particular visual field assessment, Glasgow Coma Scale if vigilance impaired, National Institute of Health Stroke Score if stroke as etiology, motor hemisyndrome evaluation with "The Motricity Index for Motor Impairment After Stroke" and Jamar. pyramidal signs in neurological evaluation . Balance (rating according to "Postural Assessment Scale for Stroke"), gait.

Cognitive examination: verbal span, geometric objects drawing span, Trail Making Test Type A and Type B.

For aphasic patient: denomination of drawn objects and Token test. For patients with visuo-spatial neglect: Bells cancellation test. Results of cerebral CT and MRI imaging. Functional outcome: Functional Independence Measure at admission and discharge.

Data management:

Patients' anonymity and data confidentiality will be respected as the data will be reported on sheets with neither the name nor the date of birth of the patient to whom a number will be assigned (separate number for each patient).

The data will be stored and archived for 10 years in a secure and closed place.

Management of adverse events :

In case of adverse effects the patient is excluded from the study, the promoter is warned, who undertakes to take the appropriate measures if any.

It should be noted, however, that no adverse effects are expected in this purely observational study.

Quality control and assurance:

Throughout the study, monitoring will be carried out in order to verify the strict application of the protocol as well as the concordance between the source data and the case report forms, corrections of the case report forms as well as the collection of undesirable events.

In the event of an audit or inspection of the regulatory authorities, the investigator will allow the persons authorized to visit the premises, installations and materials used, to meet the persons involved and to have access to the documents of the study as well as to the source data and to consult all documents of importance for the study.

Statistical analysis:

Study sample estimate: by taking the incidence of the Trephined Syndrome in the craniectomized population between 7% - 26%, it takes 100 patients with craniectomy to hope to have data comprising at least 15-20 patients with the studied syndrome. There are about 30 patients craniectomized per year at our institution, but not all of them are transferred to our neuro-rehabilitation unit and hence the duration of the study expected over 5 years.

Analysis of the data: comparison of differences in occurrence of the Trephined Syndrome (presence vs absence) in relation to delay to cranioplasty. Non-parametric variables will be compared with Mann-Whitney U test, parametric variables with t-test and categorical variables with Chi-square.

For pre- and post-cranioplasty: repeated-measure ANOVA with group factor (with / without Trephined Syndrome) will be performed.

Incidence of complications related to cranioplasty will be collected and correlation between delay to cranioplasty and presence complications will evaluated.

Criteria to stop the study: The study is stopped or at least modified if on the data published by others there strong evidence of optimal delay to cranioplasty.

Ethical Considerations:

This study will be conducted in accordance with good clinical practice. Being purely observational, it should not lead to any particular ethical problem. Treatment will not be altered unless the patient agrees to participate in the study. The free and informed consent will probably be difficult to obtain at the arrival of the patient if it has a severe neurological impairment with often an altered capacity of discernment and in this case the relatives will be asked to consent. As soon as possible the patient himself will be informed and his free consent obtained. If it is a minor patient the informed consent will be asked to their parents. All data collected will be anonymized.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 41
• Est. completion date: March 31, 2017
• Est. primary completion date: March 31, 2017
• Gender: All
• Age group: 14 Years and older

Eligibility

Inclusion Criteria:

• Patients with decompressive craniectomy for intracranial hypertension secondary to stroke, traumatic brain injury or other non-progressive cerebral pathology.

Exclusion Criteria:

• patients suffering from a rapidly evolving cerebral pathology (e.g. tumor)

• patients transferred to other hospitals before cranioplasty or whose follow-up can not be assured.

Related Conditions & MeSH terms

• Blood Loss, Surgical
• Brain Injuries
• Brain Injuries, Traumatic
• Hemorrhage
• Post Operative Hemorrhage
• Post-Op Complication
• Post-Op Infection
• Postoperative Complications
• Postoperative Hemorrhage
• Sinking Skin Flap Syndrome
• Stroke
• Syndrome
• Traumatic Brain Injury
• Trephined Syndrome

Intervention

Procedure:
• Decompressive craniectomy
Decompressive craniectomy is a surgical procedure used to treat patients with acute intractable intracranial hypertension. It includes removing a large portion of lateral skull wall in order to alleviate the effects of increased intracranial pressure and allow the brain to expand.
• Cranioplasty
Cranioplasty is a routine neurosurgical procedure to repair the continuity of the bone tissue of the skull with autologous bone or synthetic bone flap from heterologous material.

Locations

Country	Name	City	State
Switzerland	Neuro-Rehabilitation Division, University Hospital of Geneva	Genève

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Geneva

Country where clinical trial is conducted

Switzerland, 

References & Publications (18)

Akins PT, Guppy KH. Sinking skin flaps, paradoxical herniation, and external brain tamponade: a review of decompressive craniectomy management. Neurocrit Care. 2008;9(2):269-76. Review. — View Citation

Beauchamp KM, Kashuk J, Moore EE, Bolles G, Rabb C, Seinfeld J, Szentirmai O, Sauaia A. Cranioplasty after postinjury decompressive craniectomy: is timing of the essence? J Trauma. 2010 Aug;69(2):270-4. doi: 10.1097/TA.0b013e3181e491c2. — View Citation

Bijlenga P, Zumofen D, Yilmaz H, Creisson E, de Tribolet N. Orthostatic mesodiencephalic dysfunction after decompressive craniectomy. J Neurol Neurosurg Psychiatry. 2007 Apr;78(4):430-3. Epub 2006 Nov 21. — View Citation

Chang V, Hartzfeld P, Langlois M, Mahmood A, Seyfried D. Outcomes of cranial repair after craniectomy. J Neurosurg. 2010 May;112(5):1120-4. doi: 10.3171/2009.6.JNS09133. — View Citation

Dujovny M, Agner C, Aviles A. Syndrome of the trephined: theory and facts. Crit Rev Neurosurg. 1999 Sep 24;9(5):271-278. — View Citation

Fodstad H, Love JA, Ekstedt J, Fridén H, Liliequist B. Effect of cranioplasty on cerebrospinal fluid hydrodynamics in patients with the syndrome of the trephined. Acta Neurochir (Wien). 1984;70(1-2):21-30. — View Citation

Honeybul S. Complications of decompressive craniectomy for head injury. J Clin Neurosci. 2010 Apr;17(4):430-5. doi: 10.1016/j.jocn.2009.09.007. Epub 2010 Feb 23. — View Citation

Joseph V, Reilly P. Syndrome of the trephined. J Neurosurg. 2009 Oct;111(4):650-2. doi: 10.3171/2009.3.JNS0984. — View Citation

Kemmling A, Duning T, Lemcke L, Niederstadt T, Minnerup J, Wersching H, Marziniak M. Case report of MR perfusion imaging in sinking skin flap syndrome: growing evidence for hemodynamic impairment. BMC Neurol. 2010 Sep 11;10:80. doi: 10.1186/1471-2377-10-80. — View Citation

Mokri B. Orthostatic headaches in the syndrome of the trephined: resolution following cranioplasty. Headache. 2010 Jul;50(7):1206-11. doi: 10.1111/j.1526-4610.2010.01715.x. Epub 2010 Jun 18. — View Citation

Ng D, Dan NG. Cranioplasty and the syndrome of the trephined. J Clin Neurosci. 1997 Jul;4(3):346-8. — View Citation

Sarov M, Guichard JP, Chibarro S, Guettard E, Godin O, Yelnik A, George B, Bousser MG, Vahedi K; DECIMAL investigators. Sinking skin flap syndrome and paradoxical herniation after hemicraniectomy for malignant hemispheric infarction. Stroke. 2010 Mar;41(3):560-2. doi: 10.1161/STROKEAHA.109.568543. Epub 2010 Jan 7. — View Citation

Schiffer J, Gur R, Nisim U, Pollak L. Symptomatic patients after craniectomy. Surg Neurol. 1997 Mar;47(3):231-7. Review. — View Citation

Stiver SI, Wintermark M, Manley GT. Reversible monoparesis following decompressive hemicraniectomy for traumatic brain injury. J Neurosurg. 2008 Aug;109(2):245-54. doi: 10.3171/JNS/2008/109/8/0245. — View Citation

Stiver SI. Complications of decompressive craniectomy for traumatic brain injury. Neurosurg Focus. 2009 Jun;26(6):E7. doi: 10.3171/2009.4.FOCUS0965. Review. — View Citation

Thavarajah D, De Lacy P, Hussien A, Sugar A. The minimum time for cranioplasty insertion from craniectomy is six months to reduce risk of infection--a case series of 82 patients. Br J Neurosurg. 2012 Feb;26(1):78-80. doi: 10.3109/02688697.2011.603850. Epub 2011 Oct 5. — View Citation

Yadla S, Campbell PG, Chitale R, Maltenfort MG, Jabbour P, Sharan AD. Effect of early surgery, material, and method of flap preservation on cranioplasty infections: a systematic review. Neurosurgery. 2011 Apr;68(4):1124-9; discussion 1130. doi: 10.1227/NEU.0b013e31820a5470. Review. — View Citation

Yang XF, Wen L, Shen F, Li G, Lou R, Liu WG, Zhan RY. Surgical complications secondary to decompressive craniectomy in patients with a head injury: a series of 108 consecutive cases. Acta Neurochir (Wien). 2008 Dec;150(12):1241-7; discussion 1248. doi: 10.1007/s00701-008-0145-9. Epub 2008 Nov 13. — View Citation

* Note: There are 18 references in all — Click here to view all references

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Presence of Trephined Syndrome	To determine the incidence and severity of the the Trephined Syndrome in relation to delay to cranioplasty.	From patients admission to discharge from rehabilitation (approx. 3 months).
Secondary	Complications related to cranioplasty	To record the incidence of complications, such as hemorrhagic or infectious, related to cranioplasty intervention.	From patients admission to discharge from rehabilitation (approx. 3 months).
Secondary	Relation of delay to cranioplasty with neurological outcome	To investigate the relationship between cranioplasty delay and neurological outcome	From patients admission to discharge from rehabilitation (approx. 3 months).
Secondary	Relation of delay to cranioplasty with complications post-cranioplasty	To investigate the relationship between cranioplasty delay and complication rate	From patients admission to discharge from rehabilitation (approx. 3 months).