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Molecular Imaging of Inflammation With 18F-PBR06 to Identify Unstable Carotid Plaques in Patients With Stroke — PLAQINSTEP  

Stroke Clinical Trial

Official title:
Molecular Imaging of Inflammation With 18F-PBR06 to Identify Unstable Carotid Plaques in Patients With Stroke

Clinical Trial Summary

Evaluating an innovative molecular imaging technique to visualize inflammation of the atherosclerotic plaque in patients with a recent ischemic stroke (<15 days) with carotid stenosis> 50%, by performing a Positron emission tomography-computed tomography (PET-CT) with PBR06 18F, a tracer for Translocator protein (TPSO).

Clinical Trial Description

More than one third of cerebral ischemic events are related to an atheromatous plaque. Inflammation, through a key player, the macrophage, is associated with increased metabolic activity of atherosclerotic plaque and its possible rupture. Inflammation within the plate is thus a marker of instability. These data underscore the importance of a prospective evaluation of inflammation with specific imaging with PET tracers inflammation. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02513589
Study type Interventional
Source University Hospital, Bordeaux
Contact
Status Terminated
Phase Phase 2
Start date September 18, 2017
Completion date July 4, 2018
View Details
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