Sepsis Clinical Trial
Official title:
Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery (HAI)_2
The investigators will conduct qualitative interviews of hospital personnel regarding HAI prevention practices, and use coded data from these interviews to assist in developing standardized practices.
More than 400,000 coronary artery bypass grafting (CABG) procedures are performed every year
in the United States (U.S.). Patients undergoing CABG surgery are at risk for a number of
adverse sequelae, many of which impact survival and contribute to overall health-care costs.
Healthcare-acquired infections (HAIs), including pneumonia and superficial and deep sternal
wound infections, occur among 16% of CABG patients and elevate a patient's risk of mortality
and add excess upfront and long-term expenditures to the health care system.
A number of barriers prevent wide-scale improvements in HAl rates within the setting of CABG
surgery. While a number of HAl prophylaxis measures have been developed, these measures do
not fully encompass the set of practices that may impact a patient's risk of HAl. Identifying
cardiac surgery specific risk factors would serve as the foundation for targeted quality
improvement strategies. In the absence of definitive data concerning best practices, HAl
prophylaxis is variable across surgeons and institutions, resulting in unnecessary morbidity
and cost. Prior work has shown the value of implementing evidence-based protocols in the
general intensive care unit setting. To what extent the implementation of cardiac surgery
specific standardized practices results in lower HAl rates is uncertain. An understanding of
the effectiveness of this approach would certainly assist surgeons and institutions in
providing safer care to their patient populations.
Rates of HAIs vary from 0-26% across the 33 institutions performing CABG surgery in Michigan.
This application seeks to reduce this rate by identifying and subsequently implementing
standardized practices, and evaluating their impact on HAl rates. This study will be based on
the prospective data and regional quality improvement activities and infrastructure of the
Michigan Society of Thoracic and Cardiovascular Surgeons Quality Collaborative (MSTCVS-QC).
The investigators will evaluate the effectiveness of these standardized practices in reducing
HAIs regionally and relative to national rates during the same time period.
The investigators will conduct qualitative interviews of hospital personnel regarding HAI
prevention practices, and use coded data from these interviews to assist in developing
standardized practices.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT05095324 -
The Biomarker Prediction Model of Septic Risk in Infected Patients
|
||
| Completed |
NCT02714595 -
Study of Cefiderocol (S-649266) or Best Available Therapy for the Treatment of Severe Infections Caused by Carbapenem-resistant Gram-negative Pathogens
|
Phase 3 | |
| Completed |
NCT03644030 -
Phase Angle, Lean Body Mass Index and Tissue Edema and Immediate Outcome of Cardiac Surgery Patients
|
||
| Completed |
NCT02867267 -
The Efficacy and Safety of Ta1 for Sepsis
|
Phase 3 | |
| Completed |
NCT04804306 -
Sepsis Post Market Clinical Utility Simple Endpoint Study - HUMC
|
||
| Recruiting |
NCT05578196 -
Fecal Microbial Transplantation in Critically Ill Patients With Severe Infections.
|
N/A | |
| Terminated |
NCT04117568 -
The Role of Emergency Neutrophils and Glycans in Postoperative and Septic Patients
|
||
| Completed |
NCT03550794 -
Thiamine as a Renal Protective Agent in Septic Shock
|
Phase 2 | |
| Completed |
NCT04332861 -
Evaluation of Infection in Obstructing Urolithiasis
|
||
| Completed |
NCT04227652 -
Control of Fever in Septic Patients
|
N/A | |
| Enrolling by invitation |
NCT05052203 -
Researching the Effects of Sepsis on Quality Of Life, Vitality, Epigenome and Gene Expression During RecoverY From Sepsis
|
||
| Terminated |
NCT03335124 -
The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock
|
Phase 4 | |
| Recruiting |
NCT04005001 -
Machine Learning Sepsis Alert Notification Using Clinical Data
|
Phase 2 | |
| Completed |
NCT03258684 -
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Sepsis and Septic Shock
|
N/A | |
| Recruiting |
NCT05217836 -
Iron Metabolism Disorders in Patients With Sepsis or Septic Shock.
|
||
| Completed |
NCT05018546 -
Safety and Efficacy of Different Irrigation System in Retrograde Intrarenal Surgery
|
N/A | |
| Completed |
NCT03295825 -
Heparin Binding Protein in Early Sepsis Diagnosis
|
N/A | |
| Not yet recruiting |
NCT06045130 -
PUFAs in Preterm Infants
|
||
| Not yet recruiting |
NCT05361135 -
18-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in S. Aureus Bacteraemia
|
N/A | |
| Not yet recruiting |
NCT05443854 -
Impact of Aminoglycosides-based Antibiotics Combination and Protective Isolation on Outcomes in Critically-ill Neutropenic Patients With Sepsis: (Combination-Lock01)
|
Phase 3 |