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Clinical Trial Summary

This is a randomized, double-blind, placebo controlled study to investigate the effect of intravenous thiamine (vitamin B1) on renal function in septic shock.


Clinical Trial Description

This is a randomized, double-blind, placebo controlled study to investigate the effect of intravenous thiamine (vitamin B1) on renal injury in septic shock. Patients admitted with septic shock who have a lactate of at least 2.0mmol/L and do not have pre-existing renal failure requiring dialysis will be eligible for the study. Enrolled patients will be randomized to intravenous thiamine 200mg twice daily for 6 doses or matching placebo. Blood will be drawn at several time points to assess biomarkers of renal injury. Secondary endpoints include need for renal replacement therapy, length of ICU stay, and hospital mortality. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03550794
Study type Interventional
Source Beth Israel Deaconess Medical Center
Contact
Status Completed
Phase Phase 2
Start date September 4, 2018
Completion date April 5, 2022

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