Coronary Artery Disease Clinical Trial
Official title:
Pulmonary Disease in Patients Referred for Coronary CT and Association Between Spirometric Abnormalities and Coronary Calcium Score.
Several studies show an association between chronic obstructive pulmonary disease (COPD) and
coronary artery disease (CAD). Besides risk factors such as smoking, both are associated
with physical inactivity, advanced age and systemic inflammation The use of coronary
computed tomography (CCT) with multiple detectors is a diagnostic method for coronary
disease, describing the anatomy and severity of arterial obstruction. One way of estimating
the cardiovascular risk is coronary calcium score (CCS). Due to the association between COPD
and CAD, it is likely that many patients with IHD diagnosed by CT have reduced lung
function.
The aim of this observational study is to establish the correlation between the CCS and lung
function. It will also correlate the presence of irreversible airway obstruction with
significant coronary lesions.
Patients over 40 years referred to CCT who agree to participate in the study will perform a
spirometry with bronchodilator and collect a blood sample to measure serum markers of
inflammation and cardiovascular risk (glycemia, lipid profile, C reactive protein (CRP),
tumor necrosis factor-alpha (TNF-Alpha) and fibrinogen). The data will be compared in the
general population and in subgroups: smokers, former smokers and nonsmokers.
One year after the CCT patients will be contacted by the investigators and accessed for
emergency room visits, hospital admissions and fatal or nonfatal coronary or respiratory
events.
The investigators hypothesis is that reduced lung function is independently associated with
elevated CCS and is, also a risk factor for increased hospital admission and coronary
events.
The concomitant assessment of lung function and CCS can contribute knowledge about the
epidemiological association between pulmonary disease and CAD. This can also add to evidence
for the use of spirometry as a marker of cardiovascular risk.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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