Myocardial Infarction Clinical Trial
Official title:
A Study to Investigate the Protective Effects of Glucagon-like Peptide-1 (GLP-1) in Patients Undergoing Elective Angioplasty and Stenting (GOLD-PCI)
Angina is caused by narrowings or blockages within coronary arteries. Coronary angioplasty
and stenting is performed for people with angina to improve the blood supply to the heart by
placing metal tubes within the artery using balloon inflation. The procedure risks small but
significant damage to the heart muscle downstream of the balloon.
Glucagon like peptide 1 (GLP 1) is a naturally occurring hormone secreted by cells in the gut
in response to food. It acts by stimulating the release of insulin. In the heart it acts to
increase glucose uptake into cardiac muscle. GLP−1 can protect the heart and improve heart
muscle performance in people with coronary artery disease in physiological studies. This
study which assesses whether GLP−1 protects the heart during coronary angioplasty and
stenting.
The hypothesis is that GLP-1 given during elective coronary angioplasty and stenting will
reduce cardiac troponin rise (a measure of heart muscle damage) compared to placebo.
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