Quality of Life Clinical Trial
— MAGnetOfficial title:
Magnetic Resonance Adenosine Perfusion Imaging as Gatekeeper of Invasive Coronary Intervention
NCT number | NCT02580851 |
Other study ID # | 237/11 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | December 2011 |
Est. completion date | February 2018 |
Verified date | May 2018 |
Source | University of Ulm |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Current guidelines for the diagnosis and management of patients with stable coronary artery disease (CAD) strongly support the performance of non-invasive imaging techniques for the detection of myocardial ischemia prior to revascularization procedures. This recommendation originates from the strong evidence base showing the lack of prognostic benefit from percutaneous coronary interventions (PCI) over optimal medical therapy in patients without verification of myocardial ischemia. On the other hand, it could be demonstrated that patients with functionally significant coronary artery stenoses do benefit from revascularization. Cardiac magnetic resonance imaging (CMR) has emerged to be a diagnostic modality of choice for the detection of myocardial ischemia with high sensitivity and specificity. The investigators therefore designed this prospective and randomized trial to compare a CMR-driven vs. angiography-driven management of patients with stable CAD concerning major cardiac endpoints, futile angiographies and quality of life.
Status | Completed |
Enrollment | 200 |
Est. completion date | February 2018 |
Est. primary completion date | January 2018 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Patients who present themselves for the evaluation of symptoms being likely to be caused by CAD, such as exercise-related chest pain or dyspnea. Exclusion Criteria: - Unability to give written informed consent - Unstable angina - Cardiac or respiratory instability - Contraindication for CMR - Allergy to Gadolinium - Impaired renal function - Allergy to adenosine - Pregnancy |
Country | Name | City | State |
---|---|---|---|
Germany | University of Ulm | Ulm |
Lead Sponsor | Collaborator |
---|---|
University of Ulm |
Germany,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Number of cardiac deaths and non-fatal myocardial infarctions occurring in study cohort assessed by medical records | 3 years | ||
Secondary | Number of invasive procedures | Diagnostic coronary angiographies/PCIs | 3 years | |
Secondary | Quality of life | Assessed by Seattle Angina Questionnaire | 3 years |
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