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Pulpitis - Irreversible clinical trials

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NCT ID: NCT05904184 Completed - Pain, Postoperative Clinical Trials

Comparison of Calcium Silicate-based Sealer and Epoxy Resin-based Sealer

Start date: June 1, 2020
Phase: Phase 3
Study type: Interventional

Background: Sealers have been concerned with obturation. However, studies for assessing the effectiveness of endodontic treatment of sealer based on Calcium Silicate have been not much. Objective: This study aimed to assess the effectiveness of endodontic treatment of sealer based on Calcium Silicate Methods: A prospective, single-blind, clinical trial was conducted from June 2020 to December 2020 with 42 irreversible pulpitis teeth by one clinician. The postoperative pain was assessed after root canal treatment using sealer based on Calcium Silicate and sealer based on Epoxy resin after 6 hours, 12 hours, 24 hours, 48 hours, 72 hours and 7 days and inconvenient symptoms were assessed after 7 days, 3 months and 6 months. t-test, Mann-Whitney and Wilcoxon analysis were applied. Key words: obturation, sealer based on Calcium Silicate and sealer based on Epoxy resin

NCT ID: NCT05902936 Recruiting - Clinical trials for Apical Periodontitis

Evaluation of Nano Bioactive Glass Combined With i-PRF Scaffold in Vital Pulp Treatments

Start date: March 1, 2023
Phase: N/A
Study type: Interventional

With consideration of the previous studies regarding the properties of i-PRF, it will be used in combination with another bioactive material: (Nano-BAG) versus using of i-PRF only as a pulpotomy material with using a premixed bioceramic putty as a coronal sealing material in both cases, to evaluate if there is a difference in the success rate of pulpotomy in case of using Nano-BAG in combination with i-PRF So, in this study the investigators will use Nano-BAG in combination with i-PRF as a material for pulpotomy in cases of mature permanent mandibular molars and compare its outcomes with using i-PRF only and in both cases pulpotomy material will be covered with a layer of premixed bioceramic putty for coronal sealing.

NCT ID: NCT05853185 Completed - Clinical trials for Pulpitis - Irreversible

Assessing Success of MTA and Pre-mixed Bioceramic in Mature Teeth With Irreversible Pulpitis With Full Pulpotomy.

GCP
Start date: October 12, 2021
Phase: Phase 4
Study type: Interventional

Although many pulpotomy agents are commercially available, there is a dearth of clinical research comparing the efficacy of these agents in treating individuals with irreversible pulpitis. Bioceramic and MTA both have similar clinical uses, but Bioceramic is distinguished from MTA by its superior chemical, physical, and biological properties. This study aims to address this knowledge deficit by assessing the performance of biocompatible materials in pulpotomy procedures for the treatment of symptomatic permanent teeth in adults with deep caries. For permanent teeth with a completed root and a diagnosis of irreversible pulpitis without apical periodontitis, this research will compare the success rates of MTA and EBRRM pulpotomy procedures in order to provide evidence-based clinical practice guidelines for the treatment of this disease.

NCT ID: NCT05840913 Recruiting - Drug Effect Clinical Trials

Different Volumes of Articaine for Inferior Alveolar Nerve Block in Irreversible Pulpitis

IANB
Start date: April 30, 2023
Phase: Phase 2
Study type: Interventional

This is a randomized clinical trial comparing the anaesthetic efficacy of 1.8 and 3.6 mL of Articaine for inferior alveolar nerve block when treating mandibular molars with Irreversible Pulpitis

NCT ID: NCT05726357 Recruiting - Clinical trials for Pulpitis - Irreversible

Pulpotomy vs Root Canal Treatment for Teeth With Symptomatic Irreversible Pulpitis

Start date: April 1, 2023
Phase: N/A
Study type: Interventional

high-quality evidence is needed to add to current knowledge and also assess the long-term outcomes for full/complete pulpotomy after carious pulpal exposure in patients with signs and symptoms indicative of irreversible pulpitis

NCT ID: NCT05582317 Completed - Clinical trials for Pulpitis - Irreversible

Efficacy of Combination of Biodentine and Simvastatin as a Pulp Capping Materials in Vital Pulpotomy of Primary Molars

Start date: May 23, 2021
Phase: N/A
Study type: Interventional

Objective: This study was conducted to evaluate the efficacy of combination of biodentine with simvastatin as a pulpotomy agent for vital primary molars clinically and radiographically. Study design: 60 primary molars in 20 children aged 4-7 years old were randomly allocated to three groups, Biodentine, Simvastatin and combination of Biodentine and simvastatin. Clinical and radiographic examinations were conducted at 1, 3, 6, 9 and 12 months after treatment. Key words: Pulpotomy, Primary teeth, Biodentine, Simvastatin.

NCT ID: NCT05406557 Recruiting - Clinical trials for Pulpitis - Irreversible

Partial Versus Miniature Pulpotomy in Teeth With Irreversible Pulpitis

Start date: May 12, 2022
Phase: N/A
Study type: Interventional

This study will compare the outcome of partial and miniature pulpotomy in mature permanent molars with symptomatic partial irreversible pulpitis

NCT ID: NCT05402098 Recruiting - Clinical trials for Pulpitis - Irreversible

Outcome Following Endodontic Treatment Using Traditional Access Versus Conservative Access

Start date: May 12, 2022
Phase: N/A
Study type: Interventional

This study will compare the outcome of endodontic treatment using conservative or traditional access design in permanent molars with clinical signs indicative of irreversible pulpitis

NCT ID: NCT05361291 Completed - Clinical trials for Pulpitis - Irreversible

Evaluation of the Effect of Adding Dexamethasone to 2% Lidocaine

Start date: February 1, 2020
Phase: N/A
Study type: Interventional

This randomized, double-blind clinical trial aimed at the evaluation of the effect of adding dexamethasone to 2% lidocaine, given as inferior alveolar nerve block in the endodontic management of symptomatic irreversible pulpitis. One hundred and twenty four patients received one of the three IANB injections before the endodontic treatment: 2% lidocaine with 1:80 000 epinephrine; 2% lidocaine with 1:80 000 epinephrine mixed with 2mg dexamethasone; and plain 2% lidocaine mixed with 2mg dexamethasone. The anesthetia was considered successful if the patients experienced no pain or faint/weak/mild pain during root canal access preparation and instrumentation (HP VAS score <55 mm). The effect of intraligamentary injections on maximum heart rates was also recorded.

NCT ID: NCT05336682 Recruiting - Clinical trials for Pulpitis - Irreversible

Evaluation of Lesion Sterilization and Tissue Repair Techniques Versus Pulpectomy in Primary Molars With Inflammed Pulp

Start date: September 20, 2022
Phase: N/A
Study type: Interventional

Group I (Experimental group I): Lesion Sterilization and Tissue Repair with radicular instrumentation. Coronal and accessible radicular pulp tissue are extirpated using rotary files. After proper drying, the paste is placed in the cavity and canals. Group II (Experimental group II): Lesion Sterilization and Tissue Repair with no radicular instrumentation. Only the coronal pulp is removed, the pulpal floor is covered with triple antibiotic paste with propylene glycol mix. Group III (Control group): Conventional pulpectomy. Pulp tissue extirpation is done. Biomechanical preparation is done using rotary files with frequent irrigation with Chlorhexidine. The canals are dried using sterile absorbent paper points followed by obturation by the paste of Zinc oxide and eugenol.