Psoriasis Clinical Trial
Official title:
A PHASE IV, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF THE EFFECTS OF USTEKINUMAB ON VASCULAR INFLAMMATION IN PSORIASIS
The VIP-U Study is a clinical trial designed to investigate the effect of ustekinumab
(Stelara) and placebo on reducing vascular inflammation and cardiometabolic risk biomarkers
in patients with moderate to severe psoriasis.
This study will look for systemic vascular inflammation in study participants with a test
called FDG PET/CT (fluorodeoxyglucose-positron emission tomography/computed tomography). The
study will also look for cardiometabolic identifiers (heart disease and metabolic factors) in
blood samples, including markers of high cholesterol, cholesterol efflux function (the
ability of cholesterol to move in the body), metabolic factors, and inflammation.
The study will also examine the effects of ustekinumab compared to placebo on psoriasis
activity, severity and safety.
n/a
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