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Prostatic Neoplasms clinical trials

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NCT ID: NCT06468293 Recruiting - Cancer Clinical Trials

Role of Caregiver in the Clinical Pathway of Patients With Breast and Prostate Cancer

Start date: October 8, 2022
Phase: N/A
Study type: Interventional

The following randomized longitudinal study will evaluate the long term impact of caregivers' involvement in cancer care pathway, including a psychological support intervention on the dyads to be delivered after the detection of a suspected cancer and before the visit with the oncologist for discussing therapeutic options.

NCT ID: NCT06462508 Recruiting - Prostate Cancer Clinical Trials

Head-to-head Comparison of [18F]F-PSMA-N5 With [68Ga]Ga-PSMA-11 PET/CT in PCa Diagnosis, Recurrence, and Metastasis

Start date: April 20, 2024
Phase: Early Phase 1
Study type: Interventional

To prospectively evaluate the radiodrug biodistribution of a novel PET imaging agent [18F]F-PSMA-N5 in different organs of prostate cancer patients and its diagnostic efficacy in the diagnosis, recurrence and metastasis of prostate cancer, and to compare with [68Ga]Ga-PSMA-11.

NCT ID: NCT06462495 Recruiting - Prostate Cancer Clinical Trials

Head-to-head Comparison of [18F]F-PSMA-N5 With [18F]F-PSMA-1007 PET/CT in PCa Diagnosis, Recurrence, and Metastasis

Start date: April 10, 2024
Phase: Early Phase 1
Study type: Interventional

To prospectively evaluate the radiodrug biodistribution of a novel PET imaging agent [18F]F-PSMA-N5 in different organs of prostate cancer patients and its diagnostic efficacy in the diagnosis, recurrence and metastasis of prostate cancer, and to compare with [18F]F-PSMA-1007.

NCT ID: NCT06461819 Recruiting - Clinical trials for Low-to-intermediate-risk Prostate Carcinoma

Safety of Dose Escalation in Definitive Hypofractionated Radiation Therapy With SPACEOAR TM for Patients With Low-to-intermediate Risk Localized Prostate Cancer (DESAR-L)

DESAR-L
Start date: August 11, 2023
Phase: Phase 2
Study type: Interventional

A single institution with a single group, a phase II study, low- and medium-risk studies performed after biodegradable substance injection prostate cancer dosage increase. The investigator plans to evaluate grade 1 or higher rectal bleeding occurring within 3 years in patients who have received low -fractionation curative radiotherapy.

NCT ID: NCT06461793 Recruiting - Clinical trials for High Risk Prostate Carcinoma

Safety of Dose Escalation in Definitive Hypofractionated Radiation Therapy and Hormone Therapy With SpaceOAR TM for Patients With High - Risk Localized Prostate Cancer (DESAR-H)

DESAR-H
Start date: September 12, 2023
Phase: Phase 2
Study type: Interventional

Dose increase after injection of biodegradable material A safety study of high-risk prostate cancer patients who underwent low-fractionation curative radiation therapy and hormone therapy

NCT ID: NCT06461416 Recruiting - Breast Cancer Clinical Trials

A Trial for a Preliminary Estimate of the Effectiveness of a Novel Theoretical Framework

Start date: June 10, 2024
Phase: N/A
Study type: Interventional

- Aim 1: To determine the preliminary effect sizes of al ActiveHeal EST (Engage-Sustain-Triumph) Program on occupational resilience. - Aim 2: To determine the preliminary effect sizes of ActiveHeal EST (Engage-Sustain-Triumph) on health status [quality of life (QoL) and Psychological wellbeing (PWB)]. - Aim 3: To determine the extent to which ActiveHeal EST (Engage-Sustain-Triumph) Program is an acceptable and feasible Intervention for breast and prostate cancer survivors.

NCT ID: NCT06457919 Recruiting - Prostate Cancer Clinical Trials

A Study of Tinengotinib (TT-00420) in Combination With Standard Treatments in People With Prostate Cancer

Start date: June 4, 2024
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to find out whether tinengotinib in combination with abiraterone acetate and prednisone or enzalutamide is a safe treatment that causes few or mild side effects in people with metastatic castration-resistant prostate cancer (mCRPC).

NCT ID: NCT06451445 Recruiting - Prostate Cancer Clinical Trials

A Pan-Canadian, Investigator Initiated Clinical Trial With Focal IRE Directed to Intermediate-Risk Prostate Cancer

WIRED
Start date: May 16, 2024
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to investigate the safety and efficacy of Irreversible Electroporation (IRE) using NanoKnife technology in patients with intermediate-risk prostate cancer. This patient population was chosen because they would otherwise be treated with conventional therapies with high side effects. The main questions it aims to answer are: 1. Is the NanoKnife system is effective at damaging prostate tumour cells, and killing the cancer? 2. Are there any safety concerns with the procedure, or major side effects caused by the treatment? Participants will undergo IRE treatment with the NanoKnife system, and then complete follow-up appointments for 12-months after the procedure.

NCT ID: NCT06449664 Recruiting - Prostate Cancer Clinical Trials

Training for Men Undergoing Androgen Deprivation Therapy.

ADT-train
Start date: May 1, 2024
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to evaluate the effects of a newly developed training concept on men with prostate cancer undergoing androgen deprivation therapy (ADT). The main questions it aims to answer are: - How feasible and safe is the new training concept? - How efficient is the training concept to counteract side effects caused by ADT? Researchers will compare the new training concept with usual care to evaluate how efficient the training concept is to counteract the ADT-related side effects. Participants in the intervention group will perform the new training concept twice weekly for 12 weeks. Participants in the control group will only receive usual care. All participants will visit the laboratory at baseline and after 6 and 12 weeks to measure the primary and secondary outcomes.

NCT ID: NCT06441994 Recruiting - Prostate Cancer Clinical Trials

Clinical Trial of Targeted Alpha Therapy for Prostate Cancer

Alpha-PS1
Start date: May 24, 2024
Phase: Phase 1
Study type: Interventional

PSW-1025 is administered intravenously to patients with castration-resistant prostate cancer to evaluate its tolerability, safety, pharmacokinetics, absorbed dose, and efficacy, as well as to determine the recommended dose for Phase II.