Prostate Cancer Clinical Trial
Official title:
Anorectal Application of 5% Lidocaine Cream Reduces Pain Prior to Periprostatic Nerve Block During Transrectal Ultrasound Guided Biopsy: Randomized, Prospective Controlled Study
Transrectal ultrasound guided prostate biopsy is performed with a periprostatic nerve block
to the neurovascular bundle bilaterally. This does not reduce the pain due to probe insertion
and manipulation prior to nerve blockage.
Our study goal is to assess whether topical analgesia would reduce pain during the early
stages of the procedure.
Prospective, randomized controlled study. Patients signed an informed consent form. Exclusion
criteria were Lidocaine allergy or pre-planned general anesthesia.
Patients were randomized into 6 groups: (1) nerve block with 5 ml 1% lidocaine for each
neurovascular bundle + perianal topical application of 10 ml 5% lidocaine cream; (2) as in
(1) plus application of 10 ml 5% lidocaine cream evenly on rectal walls. For each approach
exposure times of 5, 10 and 20 minutes were allowed, all together 6 groups plus a control
group of patients who received periprostatic nerve block only. A 0-10 Visual analogue scale
(VAS) was filled by the patients at 5 time points: immediately after probe insertion, during
probe manipulation and prostate assessment, immediately following neurovascular bundle nerve
blockage, after prostate biopsies and a global pain estimation of the procedure.
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