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Precancerous Conditions clinical trials

View clinical trials related to Precancerous Conditions.

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NCT ID: NCT00043615 Completed - Neoplasms Clinical Trials

Collection of Blood, Bone Marrow, Tumor or Tissue Samples

Start date: July 29, 2002
Phase: N/A
Study type: Observational

This study will collect biological samples-blood, bone marrow, tumor or other tissue samples-for use in cancer-related research. The specimens will be used for various tests of drug resistance, blood vessel formation, cancer-causing proteins and immune functions. The purpose is to identify steps in the cancer development process that may serve as targets for treatment and to test various therapies for current and future cancer treatment clinical trials. Individuals 18 years of age and older with cancer or a pre-cancerous condition, such as colon polyps or cervical dysplasia, are eligible for this study, as are patients at high risk for cancer. In addition, patients who do not have cancer but require surgery, biopsy or other procedure for another medical reason may be included as normal specimen donors. Participants will have about 40 milliliters (3 tablespoons) of blood drawn upon entering the study and additional 40-ml samples drawn periodically during the course of treatment. No more than 120 ml of blood will be drawn over a 12-month period. Some patients may require a surgical procedure or biopsy (removal of tumor tissue) for medical reasons or as part of their enrollment in a research treatment study. In such cases, a portion of the specimens collected during those procedures will be used for the research studies in this protocol.

NCT ID: NCT00042900 Completed - Lymphoma Clinical Trials

Pyroxamide in Treating Patients With Advanced Cancer

Start date: April 2002
Phase: Phase 1
Study type: Interventional

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of pyroxamide in treating patients who have advanced cancer.

NCT ID: NCT00036283 Completed - Clinical trials for Precancerous Conditions

Chemoprevention of Oral Premalignant Lesions

Start date: November 2000
Phase: Phase 2
Study type: Interventional

Reduction in size and number of oral premalignant lesions

NCT ID: NCT00031759 Completed - Cervical Cancer Clinical Trials

Imiquimod in Preventing Cervical Cancer in Women With Cervical Neoplasia

Start date: June 1999
Phase: Phase 2
Study type: Interventional

RATIONALE: Chemoprevention therapy is the use of certain substances to try to prevent the development of cancer. Applying topical imiquimod before abnormal cervical cells are removed may be effective in preventing cervical cancer. PURPOSE: Randomized phase II trial to study the effectiveness of applying topical imiquimod before abnormal cervical cells are removed in preventing cervical cancer in patients who have recurrent or persistent cervical neoplasia.

NCT ID: NCT00030901 Completed - Prostate Cancer Clinical Trials

S9917, Selenium in Preventing Cancer in Patients With Neoplasia of the Prostate

Start date: February 2000
Phase: Phase 3
Study type: Interventional

RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development of cancer. The use of selenium may be an effective way to prevent prostate cancer in patients who have neoplasia of the prostate. PURPOSE: Randomized phase III trial to study the effectiveness of selenium in preventing prostate cancer in patients who have neoplasia of the prostate.

NCT ID: NCT00030264 Completed - Clinical trials for Precancerous Condition

Combination Chemotherapy in Treating Patients With Neurofibromatosis and Progressive Plexiform Neurofibromas

Start date: February 2001
Phase: Phase 2
Study type: Interventional

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining methotrexate with vinblastine may be effective treatment for neurofibromatosis type 1 associated with progressive plexiform neurofibromas. PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy in treating patients who have neurofibromatosis type 1 associated with progressive plexiform neurofibromas.

NCT ID: NCT00027976 Withdrawn - Clinical trials for Precancerous Condition

Celecoxib in Preventing Skin Cancer in Patients With Actinic Keratoses

Start date: December 2001
Phase: Phase 2/Phase 3
Study type: Interventional

RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. The use of celecoxib may be an effective way to prevent actinic keratoses. PURPOSE: Randomized phase II/III trial to determine the effectiveness of celecoxib in preventing skin cancer in patients who have actinic keratoses.

NCT ID: NCT00021294 Completed - Clinical trials for Non-melanomatous Skin Cancer

Eflornithine With or Without Triamcinolone in Preventing Nonmelanoma Skin Cancer in Patients With Actinic Keratosis

Start date: May 2001
Phase: Phase 2
Study type: Interventional

RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. Eflornithine with or without triamcinolone may be effective in preventing nonmelanoma skin cancer. PURPOSE: Randomized phase II trial to compare the effectiveness of eflornithine with or without triamcinolone in preventing nonmelanoma skin cancer in patients who have actinic keratosis.

NCT ID: NCT00006466 Active, not recruiting - Clinical trials for Multiple Myeloma and Plasma Cell Neoplasm

Beta Alethine in Treating Patients With Myeloma

Start date: August 2000
Phase: Phase 1/Phase 2
Study type: Interventional

RATIONALE: Biological therapies such as beta alethine use different ways to stimulate the immune system and stop cancer cells from growing. PURPOSE: Phase I/II trial to study the effectiveness of beta alethine in treating patients who have myeloma.

NCT ID: NCT00006379 Completed - Lymphoma Clinical Trials

Non-Ablative Allo HSCT For Hematologic Malignancies or SAA

Start date: June 2000
Phase: Phase 2
Study type: Interventional

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy used to kill cancer cells. PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy followed by peripheral stem cell transplantation in treating patients who have hematologic cancer or aplastic anemia.